| Full name: isoprenylcysteine carboxyl methyltransferase | Alias Symbol: PCCMT|HSTE14|PPMT | ||
| Type: protein-coding gene | Cytoband: 1p36.31 | ||
| Entrez ID: 23463 | HGNC ID: HGNC:5350 | Ensembl Gene: ENSG00000116237 | OMIM ID: 605851 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of ICMT:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ICMT | 23463 | 201609_x_at | 0.4175 | 0.4459 | |
| GSE20347 | ICMT | 23463 | 201609_x_at | 0.0260 | 0.8627 | |
| GSE23400 | ICMT | 23463 | 201609_x_at | 0.1967 | 0.0023 | |
| GSE26886 | ICMT | 23463 | 201609_x_at | -0.4784 | 0.0059 | |
| GSE29001 | ICMT | 23463 | 201609_x_at | 0.1416 | 0.6352 | |
| GSE38129 | ICMT | 23463 | 201609_x_at | 0.2812 | 0.0328 | |
| GSE45670 | ICMT | 23463 | 201609_x_at | 0.3302 | 0.0445 | |
| GSE53622 | ICMT | 23463 | 12820 | 0.0311 | 0.7093 | |
| GSE53624 | ICMT | 23463 | 12820 | 0.0545 | 0.4178 | |
| GSE63941 | ICMT | 23463 | 201609_x_at | -0.2693 | 0.6370 | |
| GSE77861 | ICMT | 23463 | 201609_x_at | 0.0045 | 0.9880 | |
| GSE97050 | ICMT | 23463 | A_33_P3381022 | 0.3944 | 0.2333 | |
| SRP007169 | ICMT | 23463 | RNAseq | -0.9205 | 0.0411 | |
| SRP008496 | ICMT | 23463 | RNAseq | -0.6476 | 0.0063 | |
| SRP064894 | ICMT | 23463 | RNAseq | 0.2735 | 0.0725 | |
| SRP133303 | ICMT | 23463 | RNAseq | 0.3899 | 0.0555 | |
| SRP159526 | ICMT | 23463 | RNAseq | -0.0953 | 0.6311 | |
| SRP193095 | ICMT | 23463 | RNAseq | -0.0096 | 0.9383 | |
| SRP219564 | ICMT | 23463 | RNAseq | -0.0798 | 0.7220 | |
| TCGA | ICMT | 23463 | RNAseq | 0.0239 | 0.5978 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ICMT expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ICMT:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ICMT | 23463 | 3 | 6 | 21 | |
| GSE20123 | ICMT | 23463 | 3 | 5 | 22 | |
| GSE43470 | ICMT | 23463 | 6 | 5 | 32 | |
| GSE46452 | ICMT | 23463 | 7 | 1 | 51 | |
| GSE47630 | ICMT | 23463 | 8 | 4 | 28 | |
| GSE54993 | ICMT | 23463 | 3 | 2 | 65 | |
| GSE54994 | ICMT | 23463 | 14 | 3 | 36 | |
| GSE60625 | ICMT | 23463 | 0 | 0 | 11 | |
| GSE74703 | ICMT | 23463 | 5 | 3 | 28 | |
| GSE74704 | ICMT | 23463 | 3 | 0 | 17 | |
| TCGA | ICMT | 23463 | 12 | 22 | 62 |
Total number of gains: 64; Total number of losses: 51; Total Number of normals: 373.
Somatic mutations of ICMT:
Generating mutation plots.
Highly correlated genes for ICMT:
Showing top 20/334 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ICMT | ZBTB9 | 0.724934 | 3 | 0 | 3 |
| ICMT | GINS4 | 0.697091 | 3 | 0 | 3 |
| ICMT | GSK3B | 0.692414 | 4 | 0 | 4 |
| ICMT | CTCF | 0.684771 | 3 | 0 | 3 |
| ICMT | BUB3 | 0.67447 | 3 | 0 | 3 |
| ICMT | LINC01128 | 0.67163 | 3 | 0 | 3 |
| ICMT | ALG5 | 0.671091 | 3 | 0 | 3 |
| ICMT | PRMT6 | 0.670709 | 3 | 0 | 3 |
| ICMT | XRCC6 | 0.660548 | 3 | 0 | 3 |
| ICMT | ATG3 | 0.658757 | 3 | 0 | 3 |
| ICMT | PSMG3 | 0.657047 | 3 | 0 | 3 |
| ICMT | PALB2 | 0.649499 | 5 | 0 | 5 |
| ICMT | NAA50 | 0.649118 | 5 | 0 | 4 |
| ICMT | C2CD2 | 0.646697 | 4 | 0 | 3 |
| ICMT | PHLDA3 | 0.644595 | 3 | 0 | 3 |
| ICMT | PEX11B | 0.643449 | 3 | 0 | 3 |
| ICMT | UBE3C | 0.643159 | 4 | 0 | 3 |
| ICMT | SIKE1 | 0.640033 | 3 | 0 | 3 |
| ICMT | SLC39A9 | 0.639483 | 5 | 0 | 4 |
| ICMT | SSU72 | 0.639398 | 6 | 0 | 6 |
For details and further investigation, click here
