| Full name: phosphohistidine phosphatase 1 | Alias Symbol: PHP14|HSPC141|CGI-202|DKFZp564M173|bA216L13.10 | ||
| Type: protein-coding gene | Cytoband: 9q34.3 | ||
| Entrez ID: 29085 | HGNC ID: HGNC:30033 | Ensembl Gene: ENSG00000054148 | OMIM ID: 610167 |
| Drug and gene relationship at DGIdb | |||
Expression of PHPT1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PHPT1 | 29085 | 223207_x_at | -0.1281 | 0.8790 | |
| GSE26886 | PHPT1 | 29085 | 223207_x_at | 0.6596 | 0.0086 | |
| GSE45670 | PHPT1 | 29085 | 223207_x_at | -0.3473 | 0.0154 | |
| GSE53622 | PHPT1 | 29085 | 60200 | 0.0214 | 0.7705 | |
| GSE53624 | PHPT1 | 29085 | 60200 | 0.1677 | 0.0010 | |
| GSE63941 | PHPT1 | 29085 | 223207_x_at | -0.2243 | 0.5553 | |
| GSE77861 | PHPT1 | 29085 | 223207_x_at | -0.0253 | 0.9507 | |
| GSE97050 | PHPT1 | 29085 | A_23_P83192 | -0.1108 | 0.6958 | |
| SRP007169 | PHPT1 | 29085 | RNAseq | -0.7240 | 0.0575 | |
| SRP008496 | PHPT1 | 29085 | RNAseq | -0.4379 | 0.1291 | |
| SRP064894 | PHPT1 | 29085 | RNAseq | 0.5082 | 0.1991 | |
| SRP133303 | PHPT1 | 29085 | RNAseq | -0.0458 | 0.8448 | |
| SRP159526 | PHPT1 | 29085 | RNAseq | 0.1642 | 0.5479 | |
| SRP193095 | PHPT1 | 29085 | RNAseq | -0.2562 | 0.0456 | |
| SRP219564 | PHPT1 | 29085 | RNAseq | -0.0132 | 0.9765 | |
| TCGA | PHPT1 | 29085 | RNAseq | -0.0753 | 0.2408 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PHPT1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PHPT1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PHPT1 | 29085 | 5 | 7 | 18 | |
| GSE20123 | PHPT1 | 29085 | 5 | 7 | 18 | |
| GSE43470 | PHPT1 | 29085 | 3 | 7 | 33 | |
| GSE46452 | PHPT1 | 29085 | 6 | 13 | 40 | |
| GSE47630 | PHPT1 | 29085 | 6 | 15 | 19 | |
| GSE54993 | PHPT1 | 29085 | 3 | 3 | 64 | |
| GSE54994 | PHPT1 | 29085 | 12 | 8 | 33 | |
| GSE60625 | PHPT1 | 29085 | 0 | 0 | 11 | |
| GSE74703 | PHPT1 | 29085 | 3 | 5 | 28 | |
| GSE74704 | PHPT1 | 29085 | 3 | 5 | 12 | |
| TCGA | PHPT1 | 29085 | 29 | 23 | 44 |
Total number of gains: 75; Total number of losses: 93; Total Number of normals: 320.
Somatic mutations of PHPT1:
Generating mutation plots.
Highly correlated genes for PHPT1:
Showing top 20/103 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PHPT1 | RAB7B | 0.735289 | 3 | 0 | 3 |
| PHPT1 | REEP5 | 0.725515 | 3 | 0 | 3 |
| PHPT1 | ANG | 0.723183 | 3 | 0 | 3 |
| PHPT1 | FPGS | 0.719842 | 3 | 0 | 3 |
| PHPT1 | ASS1 | 0.717795 | 3 | 0 | 3 |
| PHPT1 | SIX5 | 0.714416 | 3 | 0 | 3 |
| PHPT1 | PTPN21 | 0.706281 | 3 | 0 | 3 |
| PHPT1 | CD99 | 0.694618 | 3 | 0 | 3 |
| PHPT1 | UTS2R | 0.688897 | 3 | 0 | 3 |
| PHPT1 | CILP | 0.688583 | 3 | 0 | 3 |
| PHPT1 | RBPJ | 0.687287 | 3 | 0 | 3 |
| PHPT1 | KANK4 | 0.684806 | 3 | 0 | 3 |
| PHPT1 | EEF1D | 0.684776 | 3 | 0 | 3 |
| PHPT1 | BBS1 | 0.682804 | 3 | 0 | 3 |
| PHPT1 | GNB4 | 0.678195 | 3 | 0 | 3 |
| PHPT1 | DHRSX | 0.67633 | 3 | 0 | 3 |
| PHPT1 | CIRBP | 0.662758 | 3 | 0 | 3 |
| PHPT1 | CD63 | 0.660187 | 3 | 0 | 3 |
| PHPT1 | PIEZO1 | 0.660113 | 3 | 0 | 3 |
| PHPT1 | TIMP3 | 0.659407 | 3 | 0 | 3 |
For details and further investigation, click here
