ASS1

 

Full name: argininosuccinate synthase 1 Alias Symbol: CTLN1
Type: protein-coding gene Cytoband: 9q34.11
Entrez ID: 445 HGNC ID: HGNC:758 Ensembl Gene: ENSG00000130707 OMIM ID: 603470
Drug and gene relationship at DGIdb

 

Expression of ASS1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ASS1 445 207076_s_at 0.8809 0.3886
GSE20347 ASS1 445 207076_s_at 0.4816 0.2326
GSE23400 ASS1 445 207076_s_at 0.3065 0.0902
GSE26886 ASS1 445 207076_s_at 0.2927 0.5450
GSE29001 ASS1 445 207076_s_at 0.1995 0.7205
GSE38129 ASS1 445 207076_s_at 0.1110 0.7362
GSE45670 ASS1 445 207076_s_at 0.8588 0.0158
GSE53622 ASS1 445 13284 0.4046 0.0053
GSE53624 ASS1 445 13284 0.5058 0.0000
GSE63941 ASS1 445 207076_s_at 1.9802 0.2261
GSE77861 ASS1 445 207076_s_at -0.1100 0.9151
GSE97050 ASS1 445 A_23_P31921 -0.0625 0.8315
SRP007169 ASS1 445 RNAseq -0.2337 0.7797
SRP008496 ASS1 445 RNAseq 0.1111 0.8797
SRP064894 ASS1 445 RNAseq 0.5272 0.1345
SRP133303 ASS1 445 RNAseq 0.8591 0.0018
SRP159526 ASS1 445 RNAseq 0.2796 0.6406
SRP193095 ASS1 445 RNAseq 0.6659 0.0039
SRP219564 ASS1 445 RNAseq 0.6128 0.2757
TCGA ASS1 445 RNAseq 0.0094 0.9478

Upregulated datasets: 0; Downregulated datasets: 0.  


 

Survival by ASS1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  


Copy number change of ASS1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ASS1 445 6 9 15
GSE20123 ASS1 445 6 9 15
GSE43470 ASS1 445 5 7 31
GSE46452 ASS1 445 6 13 40
GSE47630 ASS1 445 3 16 21
GSE54993 ASS1 445 3 3 64
GSE54994 ASS1 445 12 9 32
GSE60625 ASS1 445 0 0 11
GSE74703 ASS1 445 5 5 26
GSE74704 ASS1 445 3 7 10
TCGA ASS1 445 27 26 43

Total number of gains: 76; Total number of losses: 104; Total Number of normals: 308.  


 

Somatic mutations of ASS1:

 

Generating mutation plots.

 

Highly correlated genes for ASS1:

 

Showing top 20/82 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ASS1SDCBP0.800735303
ASS1RAB2B0.763387303
ASS1BCORL10.727945303
ASS1CHD80.72676303
ASS1PHPT10.717795303
ASS1FAM200B0.710264303
ASS1CPLX10.688713303
ASS1GPX10.687025303
ASS1PPP1R16A0.683592303
ASS1ARL6IP60.67948303
ASS1HMGN30.672561403
ASS1SLC6A80.668429303
ASS1DHRSX0.665831303
ASS1TCEA10.661038403
ASS1PRELID20.645647403
ASS1MANEA0.642989303
ASS1SS18L10.641333403
ASS1IRF90.638433403
ASS1GALNT20.6384303
ASS1DGCR20.638262303

For details and further investigation, click here