| Full name: ribonuclease A family member 1, pancreatic | Alias Symbol: RAC1 | ||
| Type: protein-coding gene | Cytoband: 14q11.2 | ||
| Entrez ID: 6035 | HGNC ID: HGNC:10044 | Ensembl Gene: ENSG00000129538 | OMIM ID: 180440 |
| Drug and gene relationship at DGIdb | |||
Expression of RNASE1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RNASE1 | 6035 | 201785_at | -0.8661 | 0.4167 | |
| GSE20347 | RNASE1 | 6035 | 201785_at | 0.2595 | 0.2064 | |
| GSE23400 | RNASE1 | 6035 | 201785_at | -0.1535 | 0.2947 | |
| GSE26886 | RNASE1 | 6035 | 201785_at | 0.7857 | 0.0047 | |
| GSE29001 | RNASE1 | 6035 | 201785_at | 0.6839 | 0.0444 | |
| GSE38129 | RNASE1 | 6035 | 201785_at | -0.2827 | 0.5252 | |
| GSE45670 | RNASE1 | 6035 | 201785_at | -1.3438 | 0.0039 | |
| GSE53622 | RNASE1 | 6035 | 3003 | -0.9143 | 0.0000 | |
| GSE53624 | RNASE1 | 6035 | 3003 | -0.1873 | 0.2134 | |
| GSE63941 | RNASE1 | 6035 | 201785_at | 0.4916 | 0.4894 | |
| GSE77861 | RNASE1 | 6035 | 201785_at | 0.5474 | 0.0029 | |
| GSE97050 | RNASE1 | 6035 | A_23_P48596 | -0.5074 | 0.2398 | |
| SRP007169 | RNASE1 | 6035 | RNAseq | 1.0799 | 0.0332 | |
| SRP008496 | RNASE1 | 6035 | RNAseq | 2.0115 | 0.0000 | |
| SRP064894 | RNASE1 | 6035 | RNAseq | 0.2678 | 0.6225 | |
| SRP133303 | RNASE1 | 6035 | RNAseq | -0.2371 | 0.5617 | |
| SRP159526 | RNASE1 | 6035 | RNAseq | 0.2345 | 0.6078 | |
| SRP193095 | RNASE1 | 6035 | RNAseq | -1.4863 | 0.0064 | |
| SRP219564 | RNASE1 | 6035 | RNAseq | 0.6948 | 0.4548 | |
| TCGA | RNASE1 | 6035 | RNAseq | -0.5590 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 2.
Survival by RNASE1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RNASE1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RNASE1 | 6035 | 9 | 3 | 18 | |
| GSE20123 | RNASE1 | 6035 | 8 | 3 | 19 | |
| GSE43470 | RNASE1 | 6035 | 7 | 1 | 35 | |
| GSE46452 | RNASE1 | 6035 | 19 | 2 | 38 | |
| GSE47630 | RNASE1 | 6035 | 10 | 10 | 20 | |
| GSE54993 | RNASE1 | 6035 | 3 | 11 | 56 | |
| GSE54994 | RNASE1 | 6035 | 18 | 5 | 30 | |
| GSE60625 | RNASE1 | 6035 | 0 | 2 | 9 | |
| GSE74703 | RNASE1 | 6035 | 6 | 1 | 29 | |
| GSE74704 | RNASE1 | 6035 | 4 | 2 | 14 | |
| TCGA | RNASE1 | 6035 | 27 | 16 | 53 |
Total number of gains: 111; Total number of losses: 56; Total Number of normals: 321.
Somatic mutations of RNASE1:
Generating mutation plots.
Highly correlated genes for RNASE1:
Showing top 20/889 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RNASE1 | CCDC80 | 0.784388 | 6 | 0 | 6 |
| RNASE1 | FBLN5 | 0.759428 | 8 | 0 | 8 |
| RNASE1 | FCGRT | 0.742433 | 9 | 0 | 9 |
| RNASE1 | DEXI | 0.731208 | 3 | 0 | 3 |
| RNASE1 | OLFML1 | 0.72438 | 9 | 0 | 9 |
| RNASE1 | MFAP4 | 0.7206 | 8 | 0 | 8 |
| RNASE1 | JAM2 | 0.716906 | 7 | 0 | 7 |
| RNASE1 | PMP22 | 0.716342 | 10 | 0 | 9 |
| RNASE1 | MEOX2 | 0.71622 | 7 | 0 | 7 |
| RNASE1 | CNRIP1 | 0.711822 | 7 | 0 | 6 |
| RNASE1 | PI4KA | 0.711604 | 3 | 0 | 3 |
| RNASE1 | LRRN4CL | 0.708451 | 6 | 0 | 6 |
| RNASE1 | TP53I13 | 0.705907 | 3 | 0 | 3 |
| RNASE1 | DCN | 0.703195 | 10 | 0 | 9 |
| RNASE1 | TEAD4 | 0.702925 | 4 | 0 | 4 |
| RNASE1 | CD34 | 0.702923 | 6 | 0 | 6 |
| RNASE1 | ATP2B4 | 0.699552 | 4 | 0 | 3 |
| RNASE1 | HPGDS | 0.698847 | 6 | 0 | 6 |
| RNASE1 | FOLR2 | 0.698489 | 7 | 0 | 7 |
| RNASE1 | GIMAP5 | 0.695781 | 3 | 0 | 3 |
For details and further investigation, click here
