A PHP Error was encountered

Severity: Warning

Message: exec(): Unable to fork [nohup Rscript361 /data/webapp/var/www/html/ESCCdb/application/scripts/R/proteinDomainMut.R MFAP5 /data/webapp/var/www/html/ESCCdb/application/mutationPlots/>test.log 2>&1 &]

Filename: controllers/Result_pages.php

Line Number: 97

Backtrace:

File: /data/webapp/var/www/html/ESCCdb/application/controllers/Result_pages.php
Line: 97
Function: exec

File: /data/webapp/var/www/html/ESCCdb/application/controllers/Result_pages.php
Line: 399
Function: drawMutations

File: /data/webapp/var/www/html/ESCCdb/index.php
Line: 315
Function: require_once

Multi-Omics Database of ESCC

 

MFAP5

 

Full name: microfibril associated protein 5 Alias Symbol: MAGP2|MP25
Type: protein-coding gene Cytoband: 12p13.31
Entrez ID: 8076 HGNC ID: HGNC:29673 Ensembl Gene: ENSG00000197614 OMIM ID: 601103
Drug and gene relationship at DGIdb

 

Expression of MFAP5:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MFAP5 8076 209758_s_at -0.5193 0.7643
GSE20347 MFAP5 8076 213764_s_at 1.1467 0.0478
GSE23400 MFAP5 8076 209758_s_at 0.0833 0.7247
GSE26886 MFAP5 8076 209758_s_at 1.2285 0.0031
GSE29001 MFAP5 8076 209758_s_at 0.7634 0.0522
GSE38129 MFAP5 8076 209758_s_at 0.3707 0.5881
GSE45670 MFAP5 8076 209758_s_at -2.0385 0.0346
GSE53622 MFAP5 8076 144783 -0.3228 0.1672
GSE53624 MFAP5 8076 144783 0.5942 0.0050
GSE63941 MFAP5 8076 209758_s_at -2.6233 0.1016
GSE77861 MFAP5 8076 209758_s_at 0.8828 0.1729
GSE97050 MFAP5 8076 A_33_P3708413 -0.4454 0.6099
SRP007169 MFAP5 8076 RNAseq 6.0995 0.0000
SRP008496 MFAP5 8076 RNAseq 6.9251 0.0000
SRP064894 MFAP5 8076 RNAseq -0.1599 0.7452
SRP133303 MFAP5 8076 RNAseq 0.8359 0.0846
SRP159526 MFAP5 8076 RNAseq -1.0276 0.1940
SRP219564 MFAP5 8076 RNAseq 0.9856 0.3019
TCGA MFAP5 8076 RNAseq -0.6668 0.0018

Upregulated datasets: 4; Downregulated datasets: 1.  

 

Survival by MFAP5 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MFAP5:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MFAP5 8076 6 3 21
GSE20123 MFAP5 8076 6 3 21
GSE43470 MFAP5 8076 7 3 33
GSE46452 MFAP5 8076 10 1 48
GSE47630 MFAP5 8076 12 2 26
GSE54993 MFAP5 8076 1 10 59
GSE54994 MFAP5 8076 9 2 42
GSE60625 MFAP5 8076 0 1 10
GSE74703 MFAP5 8076 7 2 27
GSE74704 MFAP5 8076 4 2 14
TCGA MFAP5 8076 40 6 50

Total number of gains: 102; Total number of losses: 35; Total Number of normals: 351.  

 

Somatic mutations of MFAP5:

 

Generating mutation plots.

 

Highly correlated genes for MFAP5:

 

Showing top 20/516 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MFAP5EPM2A0.744096303
MFAP5ECM20.733206909
MFAP5PI4KA0.698564303
MFAP5DCN0.69014213011
MFAP5OLFML30.68594911010
MFAP5FBN10.68171411010
MFAP5MMP20.675742908
MFAP5OLFML10.67528811010
MFAP5LAMA40.67480111010
MFAP5EMP30.6688621009
MFAP5FBLN20.66694611010
MFAP5GAS10.66626211010
MFAP5CCDC800.664762606
MFAP5EFEMP20.65927811010
MFAP5HEPH0.65861511011
MFAP5DAPK10.657937504
MFAP5SFRP20.653329504
MFAP5HSPG20.651923505
MFAP5FILIP1L0.646811109
MFAP5FBLN50.6467511009

For details and further investigation, click here