| Full name: ADAM metallopeptidase domain 23 | Alias Symbol: MDC3 | ||
| Type: protein-coding gene | Cytoband: 2q33.3 | ||
| Entrez ID: 8745 | HGNC ID: HGNC:202 | Ensembl Gene: ENSG00000114948 | OMIM ID: 603710 |
| Drug and gene relationship at DGIdb | |||
Expression of ADAM23:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADAM23 | 8745 | 206046_at | 0.3153 | 0.7236 | |
| GSE20347 | ADAM23 | 8745 | 206046_at | 0.6758 | 0.0047 | |
| GSE23400 | ADAM23 | 8745 | 206046_at | 0.3922 | 0.0018 | |
| GSE26886 | ADAM23 | 8745 | 206046_at | 1.2594 | 0.0345 | |
| GSE29001 | ADAM23 | 8745 | 206046_at | 0.6122 | 0.1953 | |
| GSE38129 | ADAM23 | 8745 | 206046_at | 0.7927 | 0.0002 | |
| GSE45670 | ADAM23 | 8745 | 206046_at | 1.4077 | 0.0023 | |
| GSE53622 | ADAM23 | 8745 | 3501 | 0.7735 | 0.0005 | |
| GSE53624 | ADAM23 | 8745 | 13809 | 1.1207 | 0.0000 | |
| GSE63941 | ADAM23 | 8745 | 206046_at | -1.4482 | 0.1243 | |
| GSE77861 | ADAM23 | 8745 | 206046_at | 0.9092 | 0.0609 | |
| GSE97050 | ADAM23 | 8745 | A_23_P351667 | -0.3306 | 0.6943 | |
| SRP007169 | ADAM23 | 8745 | RNAseq | 2.5174 | 0.0013 | |
| SRP008496 | ADAM23 | 8745 | RNAseq | 3.5593 | 0.0000 | |
| SRP064894 | ADAM23 | 8745 | RNAseq | 1.5230 | 0.0001 | |
| SRP133303 | ADAM23 | 8745 | RNAseq | 0.6266 | 0.1354 | |
| SRP159526 | ADAM23 | 8745 | RNAseq | 2.2165 | 0.0016 | |
| SRP193095 | ADAM23 | 8745 | RNAseq | 1.8594 | 0.0000 | |
| SRP219564 | ADAM23 | 8745 | RNAseq | 1.8478 | 0.0399 | |
| TCGA | ADAM23 | 8745 | RNAseq | 0.6963 | 0.0189 |
Upregulated datasets: 9; Downregulated datasets: 0.
Survival by ADAM23 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ADAM23:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADAM23 | 8745 | 3 | 6 | 21 | |
| GSE20123 | ADAM23 | 8745 | 3 | 6 | 21 | |
| GSE43470 | ADAM23 | 8745 | 1 | 4 | 38 | |
| GSE46452 | ADAM23 | 8745 | 1 | 4 | 54 | |
| GSE47630 | ADAM23 | 8745 | 4 | 5 | 31 | |
| GSE54993 | ADAM23 | 8745 | 0 | 3 | 67 | |
| GSE54994 | ADAM23 | 8745 | 8 | 9 | 36 | |
| GSE60625 | ADAM23 | 8745 | 0 | 3 | 8 | |
| GSE74703 | ADAM23 | 8745 | 1 | 3 | 32 | |
| GSE74704 | ADAM23 | 8745 | 2 | 2 | 16 | |
| TCGA | ADAM23 | 8745 | 14 | 22 | 60 |
Total number of gains: 37; Total number of losses: 67; Total Number of normals: 384.
Somatic mutations of ADAM23:
Generating mutation plots.
Highly correlated genes for ADAM23:
Showing top 20/501 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADAM23 | SGTB | 0.782779 | 3 | 0 | 3 |
| ADAM23 | NFKBID | 0.76097 | 3 | 0 | 3 |
| ADAM23 | MSI2 | 0.752532 | 3 | 0 | 3 |
| ADAM23 | NTPCR | 0.74382 | 4 | 0 | 4 |
| ADAM23 | EML1 | 0.742612 | 4 | 0 | 4 |
| ADAM23 | SSH1 | 0.735494 | 3 | 0 | 3 |
| ADAM23 | TIE1 | 0.725994 | 3 | 0 | 3 |
| ADAM23 | LDLR | 0.717625 | 3 | 0 | 3 |
| ADAM23 | FAM89B | 0.717179 | 3 | 0 | 3 |
| ADAM23 | AK8 | 0.715217 | 3 | 0 | 3 |
| ADAM23 | TCEAL1 | 0.714144 | 4 | 0 | 4 |
| ADAM23 | SMOC2 | 0.705844 | 4 | 0 | 4 |
| ADAM23 | GLI2 | 0.704668 | 11 | 0 | 11 |
| ADAM23 | TXNRD1 | 0.703645 | 12 | 0 | 11 |
| ADAM23 | DAPK1 | 0.697959 | 4 | 0 | 4 |
| ADAM23 | NCOR2 | 0.697502 | 3 | 0 | 3 |
| ADAM23 | TMEM116 | 0.694289 | 6 | 0 | 6 |
| ADAM23 | SLC4A2 | 0.691362 | 3 | 0 | 3 |
| ADAM23 | PI4KA | 0.690752 | 4 | 0 | 3 |
| ADAM23 | SLC45A4 | 0.690435 | 4 | 0 | 4 |
For details and further investigation, click here
