| Full name: leucine rich repeat containing 8 VRAC subunit E | Alias Symbol: FLJ23420 | ||
| Type: protein-coding gene | Cytoband: 19p13.2 | ||
| Entrez ID: 80131 | HGNC ID: HGNC:26272 | Ensembl Gene: ENSG00000171017 | OMIM ID: 612891 |
Expression of LRRC8E:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LRRC8E | 80131 | 220174_at | 0.5753 | 0.2703 | |
| GSE20347 | LRRC8E | 80131 | 220174_at | 0.3783 | 0.1547 | |
| GSE23400 | LRRC8E | 80131 | 220174_at | 0.1074 | 0.1337 | |
| GSE26886 | LRRC8E | 80131 | 239433_at | 1.4432 | 0.0007 | |
| GSE29001 | LRRC8E | 80131 | 220174_at | -0.0298 | 0.9387 | |
| GSE38129 | LRRC8E | 80131 | 220174_at | 0.6103 | 0.0156 | |
| GSE45670 | LRRC8E | 80131 | 239433_at | 0.6829 | 0.0269 | |
| GSE63941 | LRRC8E | 80131 | 220174_at | 0.7361 | 0.0544 | |
| GSE77861 | LRRC8E | 80131 | 239433_at | 1.3298 | 0.0045 | |
| GSE97050 | LRRC8E | 80131 | A_24_P348203 | 0.7313 | 0.1413 | |
| SRP007169 | LRRC8E | 80131 | RNAseq | -0.1421 | 0.6966 | |
| SRP008496 | LRRC8E | 80131 | RNAseq | -0.1914 | 0.4933 | |
| SRP064894 | LRRC8E | 80131 | RNAseq | 0.1539 | 0.6448 | |
| SRP133303 | LRRC8E | 80131 | RNAseq | 0.5074 | 0.0576 | |
| SRP159526 | LRRC8E | 80131 | RNAseq | 0.1260 | 0.8025 | |
| SRP193095 | LRRC8E | 80131 | RNAseq | 0.4183 | 0.0187 | |
| TCGA | LRRC8E | 80131 | RNAseq | 0.3896 | 0.0051 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by LRRC8E expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of LRRC8E:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LRRC8E | 80131 | 4 | 3 | 23 | |
| GSE20123 | LRRC8E | 80131 | 3 | 2 | 25 | |
| GSE43470 | LRRC8E | 80131 | 2 | 7 | 34 | |
| GSE46452 | LRRC8E | 80131 | 47 | 1 | 11 | |
| GSE47630 | LRRC8E | 80131 | 5 | 7 | 28 | |
| GSE54993 | LRRC8E | 80131 | 16 | 3 | 51 | |
| GSE54994 | LRRC8E | 80131 | 6 | 14 | 33 | |
| GSE60625 | LRRC8E | 80131 | 9 | 0 | 2 | |
| GSE74703 | LRRC8E | 80131 | 2 | 4 | 30 | |
| GSE74704 | LRRC8E | 80131 | 0 | 2 | 18 | |
| TCGA | LRRC8E | 80131 | 9 | 20 | 67 |
Total number of gains: 103; Total number of losses: 63; Total Number of normals: 322.
Somatic mutations of LRRC8E:
Generating mutation plots.
Highly correlated genes for LRRC8E:
Showing top 20/433 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LRRC8E | GALNS | 0.732023 | 5 | 0 | 5 |
| LRRC8E | MED10 | 0.725451 | 3 | 0 | 3 |
| LRRC8E | ZNF317 | 0.705892 | 3 | 0 | 3 |
| LRRC8E | GCNT7 | 0.687147 | 3 | 0 | 3 |
| LRRC8E | PSMA7 | 0.680073 | 4 | 0 | 3 |
| LRRC8E | CHST7 | 0.677397 | 4 | 0 | 3 |
| LRRC8E | ANGEL1 | 0.674404 | 3 | 0 | 3 |
| LRRC8E | C10orf95 | 0.670271 | 3 | 0 | 3 |
| LRRC8E | WDR66 | 0.66633 | 5 | 0 | 5 |
| LRRC8E | SPATA2L | 0.661846 | 5 | 0 | 4 |
| LRRC8E | MPLKIP | 0.660876 | 5 | 0 | 5 |
| LRRC8E | PINX1 | 0.660242 | 4 | 0 | 3 |
| LRRC8E | MRGBP | 0.659045 | 4 | 0 | 4 |
| LRRC8E | YTHDF1 | 0.657176 | 3 | 0 | 3 |
| LRRC8E | MCM5 | 0.656329 | 4 | 0 | 3 |
| LRRC8E | WNT7B | 0.653479 | 6 | 0 | 5 |
| LRRC8E | RCC2 | 0.649583 | 4 | 0 | 3 |
| LRRC8E | EIF3B | 0.648271 | 5 | 0 | 5 |
| LRRC8E | TRABD | 0.647862 | 4 | 0 | 4 |
| LRRC8E | CEBPB | 0.646513 | 4 | 0 | 3 |
For details and further investigation, click here
