CCND1

 

Full name: cyclin D1 Alias Symbol: U21B31
Type: protein-coding gene Cytoband: 11q13.3
Entrez ID: 595 HGNC ID: HGNC:1582 Ensembl Gene: ENSG00000110092 OMIM ID: 168461
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 166/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

CCND1 involved pathways:

KEGG pathway Description View
hsa04068FoxO signaling pathway
hsa04110Cell cycle
hsa04115p53 signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04152AMPK signaling pathway
hsa04310Wnt signaling pathway
hsa04340Hedgehog signaling pathway
hsa04390Hippo signaling pathway
hsa04510Focal adhesion
hsa04630Jak-STAT signaling pathway
hsa04917Prolactin signaling pathway
hsa04919Thyroid hormone signaling pathway
hsa04921Oxytocin signaling pathway
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05162Measles
hsa05166HTLV-I infection
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05210Colorectal cancer
hsa05212Pancreatic cancer
hsa05213Endometrial cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa05216Thyroid cancer
hsa05218Melanoma
hsa05219Bladder cancer
hsa05220Chronic myeloid leukemia
hsa05221Acute myeloid leukemia
hsa05222Small cell lung cancer
hsa05223Non-small cell lung cancer

 

Expression of CCND1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CCND1 595 208712_at 0.3391 0.8797
GSE20347 CCND1 595 208712_at 0.1095 0.8248
GSE23400 CCND1 595 208712_at -0.0202 0.9336
GSE26886 CCND1 595 208712_at -0.2329 0.6573
GSE29001 CCND1 595 208712_at 0.2530 0.6228
GSE38129 CCND1 595 208712_at 0.4023 0.2511
GSE45670 CCND1 595 208712_at 0.1344 0.7534
GSE53622 CCND1 595 50481 0.3333 0.0641
GSE53624 CCND1 595 50481 0.0401 0.7984
GSE63941 CCND1 595 208712_at -0.4461 0.6843
GSE77861 CCND1 595 208712_at 0.1609 0.8323
GSE97050 CCND1 595 A_23_P202837 0.5738 0.3444
SRP007169 CCND1 595 RNAseq 2.8853 0.0617
SRP008496 CCND1 595 RNAseq 2.1924 0.0317
SRP064894 CCND1 595 RNAseq 0.0604 0.8945
SRP133303 CCND1 595 RNAseq 1.1533 0.0000
SRP159526 CCND1 595 RNAseq 1.5676 0.0165
SRP193095 CCND1 595 RNAseq 0.6365 0.0071
SRP219564 CCND1 595 RNAseq 1.6598 0.0469
TCGA CCND1 595 RNAseq 0.2221 0.0257

Upregulated datasets: 4; Downregulated datasets: 0.  

 

Survival by CCND1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CCND1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CCND1 595 20 1 9
GSE20123 CCND1 595 20 1 9
GSE43470 CCND1 595 16 2 25
GSE46452 CCND1 595 37 0 22
GSE47630 CCND1 595 20 1 19
GSE54993 CCND1 595 1 25 44
GSE54994 CCND1 595 27 3 23
GSE60625 CCND1 595 0 4 7
GSE74703 CCND1 595 13 1 22
GSE74704 CCND1 595 13 0 7
TCGA CCND1 595 62 3 31

Total number of gains: 229; Total number of losses: 41; Total Number of normals: 218.  

 

Somatic mutations of CCND1:

 

Generating mutation plots.

 

Highly correlated genes for CCND1:

 

Showing top 20/70 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CCND1PWWP2A0.7071303
CCND1CTTN0.69666313010
CCND1MIPOL10.690316303
CCND1FADD0.6865731009
CCND1PPP2R3C0.685483303
CCND1PTPN130.684662303
CCND1SRGAP30.677084303
CCND1PAK20.673574303
CCND1E2F80.668878303
CCND1PIP5K1B0.666865303
CCND1LCMT10.660019303
CCND1NEK110.658644404
CCND1PPFIA10.65618712011
CCND1HEATR5A0.651322303
CCND1RALGAPA10.6458403
CCND1KIF3A0.63673303
CCND1CNOT40.632115303
CCND1SPATA5L10.631669303
CCND1STAG10.624921303
CCND1PCTP0.624776303

For details and further investigation, click here