IGF1

 

Full name: insulin like growth factor 1 Alias Symbol: IGF1A|IGFI|IGF-I|IGF
Type: protein-coding gene Cytoband: 12q23.2
Entrez ID: 3479 HGNC ID: HGNC:5464 Ensembl Gene: ENSG00000017427 OMIM ID: 147440
Drug and gene relationship at DGIdb

 

IGF1 involved pathways:

KEGG pathway Description View
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04066HIF-1 signaling pathway
hsa04068FoxO signaling pathway
hsa04114Oocyte meiosis
hsa04115p53 signaling pathway
hsa04150mTOR signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04152AMPK signaling pathway
hsa04211Longevity regulating pathway - mammal
hsa04213Longevity regulating pathway - multiple species
hsa04510Focal adhesion
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04730Long-term depression
hsa04750Inflammatory mediator regulation of TRP channels
hsa04913Ovarian steroidogenesis
hsa04914Progesterone-mediated oocyte maturation
hsa04960Aldosterone-regulated sodium reabsorption
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa05218Melanoma

 

Expression of IGF1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 IGF1 3479 209541_at -1.6176 0.1395
GSE20347 IGF1 3479 211577_s_at -0.0733 0.4813
GSE23400 IGF1 3479 209540_at 0.0117 0.9456
GSE26886 IGF1 3479 211577_s_at 0.1052 0.4617
GSE29001 IGF1 3479 209540_at -0.1713 0.6204
GSE38129 IGF1 3479 209542_x_at -0.4489 0.1614
GSE45670 IGF1 3479 209542_x_at -0.6753 0.0000
GSE53622 IGF1 3479 34774 -1.4324 0.0000
GSE53624 IGF1 3479 34774 -0.8285 0.0000
GSE63941 IGF1 3479 211577_s_at -2.0981 0.0001
GSE77861 IGF1 3479 211577_s_at -0.0781 0.5741
GSE97050 IGF1 3479 A_23_P13907 0.4736 0.3192
SRP007169 IGF1 3479 RNAseq 2.3555 0.0001
SRP008496 IGF1 3479 RNAseq 3.2694 0.0000
SRP064894 IGF1 3479 RNAseq 2.4875 0.0001
SRP133303 IGF1 3479 RNAseq -0.3117 0.4914
SRP159526 IGF1 3479 RNAseq 0.3991 0.6560
SRP193095 IGF1 3479 RNAseq 0.7781 0.0077
SRP219564 IGF1 3479 RNAseq 1.8281 0.1184
TCGA IGF1 3479 RNAseq -0.6547 0.0020

Upregulated datasets: 3; Downregulated datasets: 2.  

 

Survival by IGF1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of IGF1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 IGF1 3479 3 2 25
GSE20123 IGF1 3479 3 2 25
GSE43470 IGF1 3479 2 0 41
GSE46452 IGF1 3479 9 1 49
GSE47630 IGF1 3479 9 1 30
GSE54993 IGF1 3479 0 5 65
GSE54994 IGF1 3479 4 2 47
GSE60625 IGF1 3479 0 0 11
GSE74703 IGF1 3479 2 0 34
GSE74704 IGF1 3479 1 2 17
TCGA IGF1 3479 18 12 66

Total number of gains: 51; Total number of losses: 27; Total Number of normals: 410.  

 

Somatic mutations of IGF1:

 

Generating mutation plots.

 

Highly correlated genes for IGF1:

 

Showing top 20/920 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
IGF1GPIHBP10.806057404
IGF1LETMD10.753227303
IGF1CXCL120.75029210010
IGF1TNFSF120.749782303
IGF1GIMAP50.749741303
IGF1AFF30.747363303
IGF1GIMAP70.733014505
IGF1RSPO30.732194706
IGF1A2M0.7271951009
IGF1PREX20.725241404
IGF1FAM13C0.722241404
IGF1ARHGAP150.720036303
IGF1PLA2G2A0.719003908
IGF1RSPO10.715793606
IGF1JAM20.7109510010
IGF1GNA140.71021707
IGF1ARHGAP310.709035706
IGF1OGN0.70682211010
IGF1CHRDL20.706384606
IGF1MAN1C10.7035351008

For details and further investigation, click here