| Full name: X-C motif chemokine ligand 1 | Alias Symbol: LPTN|ATAC|SCM-1a|SCM-1 | ||
| Type: protein-coding gene | Cytoband: 1q24.2 | ||
| Entrez ID: 6375 | HGNC ID: HGNC:10645 | Ensembl Gene: ENSG00000143184 | OMIM ID: 600250 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
XCL1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04062 | Chemokine signaling pathway |
Expression of XCL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | XCL1 | 6375 | 206366_x_at | 1.4937 | 0.0501 | |
| GSE20347 | XCL1 | 6375 | 206366_x_at | 1.2243 | 0.0000 | |
| GSE23400 | XCL1 | 6375 | 206366_x_at | 0.4193 | 0.0000 | |
| GSE26886 | XCL1 | 6375 | 206366_x_at | 1.8240 | 0.0000 | |
| GSE29001 | XCL1 | 6375 | 206366_x_at | 1.2810 | 0.0000 | |
| GSE38129 | XCL1 | 6375 | 206366_x_at | 1.1633 | 0.0000 | |
| GSE45670 | XCL1 | 6375 | 206366_x_at | 1.1209 | 0.0006 | |
| GSE53622 | XCL1 | 6375 | 148294 | 1.2899 | 0.0000 | |
| GSE53624 | XCL1 | 6375 | 148294 | 1.4726 | 0.0000 | |
| GSE63941 | XCL1 | 6375 | 206366_x_at | 2.0900 | 0.0207 | |
| GSE77861 | XCL1 | 6375 | 206366_x_at | 0.6044 | 0.0550 | |
| SRP133303 | XCL1 | 6375 | RNAseq | 2.5833 | 0.0000 | |
| SRP159526 | XCL1 | 6375 | RNAseq | 3.4926 | 0.0000 | |
| SRP219564 | XCL1 | 6375 | RNAseq | 3.7784 | 0.0000 | |
| TCGA | XCL1 | 6375 | RNAseq | 1.7940 | 0.0000 |
Upregulated datasets: 12; Downregulated datasets: 0.
Survival by XCL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of XCL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | XCL1 | 6375 | 11 | 1 | 18 | |
| GSE20123 | XCL1 | 6375 | 11 | 1 | 18 | |
| GSE43470 | XCL1 | 6375 | 7 | 2 | 34 | |
| GSE46452 | XCL1 | 6375 | 3 | 1 | 55 | |
| GSE47630 | XCL1 | 6375 | 14 | 0 | 26 | |
| GSE54993 | XCL1 | 6375 | 0 | 6 | 64 | |
| GSE54994 | XCL1 | 6375 | 16 | 0 | 37 | |
| GSE60625 | XCL1 | 6375 | 0 | 0 | 11 | |
| GSE74703 | XCL1 | 6375 | 7 | 2 | 27 | |
| GSE74704 | XCL1 | 6375 | 5 | 0 | 15 | |
| TCGA | XCL1 | 6375 | 43 | 3 | 50 |
Total number of gains: 117; Total number of losses: 16; Total Number of normals: 355.
Somatic mutations of XCL1:
Generating mutation plots.
Highly correlated genes for XCL1:
Showing top 20/1113 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| XCL1 | CRTC2 | 0.734088 | 3 | 0 | 3 |
| XCL1 | SLC39A3 | 0.733786 | 3 | 0 | 3 |
| XCL1 | GOLM1 | 0.716488 | 5 | 0 | 5 |
| XCL1 | ADAR | 0.704768 | 10 | 0 | 8 |
| XCL1 | IPO9 | 0.702621 | 9 | 0 | 8 |
| XCL1 | DHRSX | 0.696643 | 3 | 0 | 3 |
| XCL1 | ASCL2 | 0.690994 | 4 | 0 | 4 |
| XCL1 | HOXD8 | 0.690277 | 6 | 0 | 6 |
| XCL1 | CMTM4 | 0.685559 | 4 | 0 | 3 |
| XCL1 | DPY19L4 | 0.685377 | 10 | 0 | 9 |
| XCL1 | KRTCAP2 | 0.68099 | 4 | 0 | 3 |
| XCL1 | VANGL2 | 0.680846 | 3 | 0 | 3 |
| XCL1 | NVL | 0.678578 | 10 | 0 | 10 |
| XCL1 | THOC1 | 0.677549 | 4 | 0 | 3 |
| XCL1 | TMEM9 | 0.673434 | 6 | 0 | 5 |
| XCL1 | PLEKHG4 | 0.67342 | 3 | 0 | 3 |
| XCL1 | HOXC9 | 0.672944 | 5 | 0 | 4 |
| XCL1 | ACVR1C | 0.670979 | 5 | 0 | 4 |
| XCL1 | PLXNA1 | 0.669267 | 10 | 0 | 9 |
| XCL1 | FNDC3B | 0.66925 | 9 | 0 | 8 |
For details and further investigation, click here
