NELFB

 

Full name: negative elongation factor complex member B Alias Symbol: KIAA1182|NELF-B
Type: protein-coding gene Cytoband: 9q34.3
Entrez ID: 25920 HGNC ID: HGNC:24324 Ensembl Gene: ENSG00000188986 OMIM ID: 611180
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of NELFB:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 NELFB 25920 202757_at 0.3154 0.3955
GSE20347 NELFB 25920 202757_at 0.1756 0.2251
GSE23400 NELFB 25920 202757_at 0.4843 0.0000
GSE26886 NELFB 25920 202757_at 0.8526 0.0000
GSE29001 NELFB 25920 202757_at 0.2086 0.3625
GSE38129 NELFB 25920 202757_at 0.1979 0.0375
GSE45670 NELFB 25920 202757_at 0.2559 0.0176
GSE53622 NELFB 25920 25105 0.0118 0.8856
GSE53624 NELFB 25920 25105 0.2243 0.0007
GSE63941 NELFB 25920 202757_at 0.4045 0.2486
GSE77861 NELFB 25920 202757_at 0.3904 0.0284
SRP007169 NELFB 25920 RNAseq -0.1544 0.6732
SRP008496 NELFB 25920 RNAseq -0.2431 0.2229
SRP064894 NELFB 25920 RNAseq 0.6937 0.0120
SRP133303 NELFB 25920 RNAseq 0.1461 0.4057
SRP159526 NELFB 25920 RNAseq 0.2622 0.1017
SRP193095 NELFB 25920 RNAseq 0.1732 0.0734
SRP219564 NELFB 25920 RNAseq 0.0311 0.9170

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by NELFB expression:

 

GSE53622GSE53624

 

Note: Click image to view full size file.  

Copy number change of NELFB:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 NELFB 25920 5 7 18
GSE20123 NELFB 25920 5 7 18
GSE43470 NELFB 25920 3 7 33
GSE46452 NELFB 25920 6 13 40
GSE47630 NELFB 25920 6 15 19
GSE54993 NELFB 25920 3 3 64
GSE54994 NELFB 25920 12 7 34
GSE60625 NELFB 25920 0 0 11
GSE74703 NELFB 25920 3 5 28
GSE74704 NELFB 25920 3 5 12
TCGA NELFB 25920 30 23 43

Total number of gains: 76; Total number of losses: 92; Total Number of normals: 320.  

 

Somatic mutations of NELFB:

 

Generating mutation plots.

 

Highly correlated genes for NELFB:

 

Showing top 20/538 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
NELFBZMYND190.72294606
NELFBRIOK10.720694303
NELFBRABL60.699724404
NELFBCHTF180.694317404
NELFBPLEKHG40.692192303
NELFBMEA10.69022303
NELFBMORC20.689231505
NELFBSLC33A10.686568403
NELFBSHKBP10.686516303
NELFBSAFB20.686122303
NELFBZNF1480.67811303
NELFBATR0.675341503
NELFBLRRC580.671626403
NELFBGTF2IRD20.670568403
NELFBFNDC3B0.670185303
NELFBKPNA10.668113403
NELFBTBCCD10.666501404
NELFBACBD60.661548303
NELFBHOXD130.660676404
NELFBMETTL230.659755303

For details and further investigation, click here