MRPS2

 

Full name: mitochondrial ribosomal protein S2 Alias Symbol: CGI-91
Type: protein-coding gene Cytoband: 9q34.3
Entrez ID: 51116 HGNC ID: HGNC:14495 Ensembl Gene: ENSG00000122140 OMIM ID: 611971
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of MRPS2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MRPS2 51116 218001_at 0.2920 0.3728
GSE20347 MRPS2 51116 218001_at 0.3765 0.0560
GSE23400 MRPS2 51116 218001_at 0.6385 0.0000
GSE26886 MRPS2 51116 218001_at 1.0676 0.0000
GSE29001 MRPS2 51116 218001_at 0.3703 0.1585
GSE38129 MRPS2 51116 218001_at 0.5023 0.0013
GSE45670 MRPS2 51116 218001_at 0.4106 0.0037
GSE53622 MRPS2 51116 74630 0.3239 0.0001
GSE53624 MRPS2 51116 74630 0.7141 0.0000
GSE63941 MRPS2 51116 218001_at 1.4951 0.0022
GSE77861 MRPS2 51116 218001_at 0.4672 0.0363
GSE97050 MRPS2 51116 A_23_P135104 0.1800 0.4413
SRP007169 MRPS2 51116 RNAseq 0.6892 0.1937
SRP008496 MRPS2 51116 RNAseq 0.4211 0.1704
SRP064894 MRPS2 51116 RNAseq 0.7727 0.0230
SRP133303 MRPS2 51116 RNAseq 0.2971 0.0945
SRP159526 MRPS2 51116 RNAseq 0.4808 0.0505
SRP193095 MRPS2 51116 RNAseq 0.3397 0.0213
SRP219564 MRPS2 51116 RNAseq 0.6986 0.1442
TCGA MRPS2 51116 RNAseq 0.1196 0.0581

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by MRPS2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MRPS2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MRPS2 51116 4 7 19
GSE20123 MRPS2 51116 4 7 19
GSE43470 MRPS2 51116 3 7 33
GSE46452 MRPS2 51116 6 13 40
GSE47630 MRPS2 51116 6 15 19
GSE54993 MRPS2 51116 3 3 64
GSE54994 MRPS2 51116 11 9 33
GSE60625 MRPS2 51116 0 0 11
GSE74703 MRPS2 51116 3 5 28
GSE74704 MRPS2 51116 2 5 13
TCGA MRPS2 51116 28 25 43

Total number of gains: 70; Total number of losses: 96; Total Number of normals: 322.  

 

Somatic mutations of MRPS2:

 

Generating mutation plots.

 

Highly correlated genes for MRPS2:

 

Showing top 20/475 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MRPS2FAM24B0.767876303
MRPS2C7orf260.747369303
MRPS2SYCE1L0.741686303
MRPS2NTMT10.740952505
MRPS2OTUD50.724732303
MRPS2JAKMIP30.715203505
MRPS2CNOT30.699051706
MRPS2PSMB50.697869909
MRPS2PMPCA0.69764613012
MRPS2SMPD40.686212303
MRPS2C2orf810.685134303
MRPS2UBE2S0.6825451009
MRPS2SLC27A10.679641403
MRPS2SAPCD20.678842706
MRPS2ZNF5110.67463707
MRPS2C6orf2260.672899303
MRPS2RANBP30.67138505
MRPS2FBRSL10.666899503
MRPS2LRR10.666755605
MRPS2ZNF385A0.665047303

For details and further investigation, click here