| Full name: premelanosome protein | Alias Symbol: D12S53E|SI|Pmel17|gp100 | ||
| Type: protein-coding gene | Cytoband: 12q13.2 | ||
| Entrez ID: 6490 | HGNC ID: HGNC:10880 | Ensembl Gene: ENSG00000185664 | OMIM ID: 155550 |
| Related drugs: HEXAMETHYLENEBISACETAMIDE... [more] | |||
Expression of PMEL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PMEL | 6490 | 209848_s_at | -0.1057 | 0.5495 | |
| GSE20347 | PMEL | 6490 | 209848_s_at | -0.0522 | 0.4757 | |
| GSE23400 | PMEL | 6490 | 209848_s_at | -0.1568 | 0.0000 | |
| GSE26886 | PMEL | 6490 | 209848_s_at | -0.0058 | 0.9666 | |
| GSE29001 | PMEL | 6490 | 209848_s_at | -0.3591 | 0.1765 | |
| GSE38129 | PMEL | 6490 | 209848_s_at | -0.0446 | 0.5987 | |
| GSE45670 | PMEL | 6490 | 209848_s_at | 0.0432 | 0.6445 | |
| GSE53622 | PMEL | 6490 | 52773 | 0.0419 | 0.8027 | |
| GSE53624 | PMEL | 6490 | 52773 | 0.0018 | 0.9905 | |
| GSE63941 | PMEL | 6490 | 209848_s_at | 0.3169 | 0.4223 | |
| GSE77861 | PMEL | 6490 | 209848_s_at | -0.0979 | 0.4377 | |
| GSE97050 | PMEL | 6490 | A_23_P312851 | 0.0882 | 0.8136 | |
| SRP064894 | PMEL | 6490 | RNAseq | 0.7155 | 0.0106 | |
| SRP133303 | PMEL | 6490 | RNAseq | -0.3515 | 0.2040 | |
| SRP159526 | PMEL | 6490 | RNAseq | 0.4051 | 0.4909 | |
| SRP193095 | PMEL | 6490 | RNAseq | -0.0541 | 0.6929 | |
| SRP219564 | PMEL | 6490 | RNAseq | -0.1613 | 0.7648 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PMEL expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of PMEL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PMEL | 6490 | 6 | 2 | 22 | |
| GSE20123 | PMEL | 6490 | 6 | 1 | 23 | |
| GSE43470 | PMEL | 6490 | 4 | 0 | 39 | |
| GSE46452 | PMEL | 6490 | 8 | 1 | 50 | |
| GSE47630 | PMEL | 6490 | 10 | 2 | 28 | |
| GSE54993 | PMEL | 6490 | 0 | 5 | 65 | |
| GSE54994 | PMEL | 6490 | 4 | 1 | 48 | |
| GSE60625 | PMEL | 6490 | 0 | 0 | 11 | |
| GSE74703 | PMEL | 6490 | 4 | 0 | 32 | |
| GSE74704 | PMEL | 6490 | 4 | 1 | 15 | |
| TCGA | PMEL | 6490 | 15 | 10 | 71 |
Total number of gains: 61; Total number of losses: 23; Total Number of normals: 404.
Somatic mutations of PMEL:
Generating mutation plots.
Highly correlated genes for PMEL:
Showing top 20/205 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PMEL | TBC1D20 | 0.712548 | 3 | 0 | 3 |
| PMEL | TRMT2B | 0.710437 | 3 | 0 | 3 |
| PMEL | DCTN2 | 0.695787 | 3 | 0 | 3 |
| PMEL | FIG4 | 0.674185 | 3 | 0 | 3 |
| PMEL | HOXC8 | 0.67012 | 3 | 0 | 3 |
| PMEL | ZNF414 | 0.662817 | 3 | 0 | 3 |
| PMEL | UBAP1 | 0.658388 | 4 | 0 | 3 |
| PMEL | ACSS2 | 0.653271 | 3 | 0 | 3 |
| PMEL | INPP5D | 0.652389 | 3 | 0 | 3 |
| PMEL | COMMD1 | 0.649529 | 3 | 0 | 3 |
| PMEL | MYCN | 0.649269 | 5 | 0 | 4 |
| PMEL | ARGLU1 | 0.648058 | 3 | 0 | 3 |
| PMEL | BAGE | 0.645291 | 4 | 0 | 3 |
| PMEL | TNIP1 | 0.6447 | 4 | 0 | 3 |
| PMEL | ARSE | 0.638247 | 3 | 0 | 3 |
| PMEL | KCTD11 | 0.630903 | 3 | 0 | 3 |
| PMEL | PTPRJ | 0.624832 | 4 | 0 | 4 |
| PMEL | KRT76 | 0.622775 | 5 | 0 | 4 |
| PMEL | DNASE1L1 | 0.617636 | 3 | 0 | 3 |
| PMEL | PRLR | 0.617476 | 5 | 0 | 4 |
For details and further investigation, click here
