| Full name: inositol polyphosphate-5-phosphatase D | Alias Symbol: SHIP|hp51CN|SHIP1 | ||
| Type: protein-coding gene | Cytoband: 2q37.1 | ||
| Entrez ID: 3635 | HGNC ID: HGNC:6079 | Ensembl Gene: ENSG00000168918 | OMIM ID: 601582 |
| Drug and gene relationship at DGIdb | |||
Expression of INPP5D:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | INPP5D | 3635 | 203332_s_at | -0.1034 | 0.9309 | |
| GSE20347 | INPP5D | 3635 | 203332_s_at | -0.2285 | 0.2159 | |
| GSE23400 | INPP5D | 3635 | 203332_s_at | -0.1557 | 0.0036 | |
| GSE26886 | INPP5D | 3635 | 203332_s_at | -0.6999 | 0.0026 | |
| GSE29001 | INPP5D | 3635 | 203332_s_at | -0.0743 | 0.7754 | |
| GSE38129 | INPP5D | 3635 | 203332_s_at | -0.4032 | 0.0421 | |
| GSE45670 | INPP5D | 3635 | 203332_s_at | -0.3502 | 0.1802 | |
| GSE53622 | INPP5D | 3635 | 68171 | -0.6528 | 0.0000 | |
| GSE53624 | INPP5D | 3635 | 68171 | -0.8716 | 0.0000 | |
| GSE63941 | INPP5D | 3635 | 203332_s_at | 0.2740 | 0.4975 | |
| GSE77861 | INPP5D | 3635 | 203332_s_at | -0.2267 | 0.1719 | |
| GSE97050 | INPP5D | 3635 | A_23_P61149 | 0.5240 | 0.2747 | |
| SRP007169 | INPP5D | 3635 | RNAseq | -0.2547 | 0.7009 | |
| SRP008496 | INPP5D | 3635 | RNAseq | -0.5263 | 0.1923 | |
| SRP064894 | INPP5D | 3635 | RNAseq | 0.1318 | 0.6167 | |
| SRP133303 | INPP5D | 3635 | RNAseq | -0.6944 | 0.0030 | |
| SRP159526 | INPP5D | 3635 | RNAseq | -1.4177 | 0.0342 | |
| SRP193095 | INPP5D | 3635 | RNAseq | -0.6284 | 0.0024 | |
| SRP219564 | INPP5D | 3635 | RNAseq | 0.2212 | 0.5369 | |
| TCGA | INPP5D | 3635 | RNAseq | -0.2308 | 0.0796 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by INPP5D expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of INPP5D:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | INPP5D | 3635 | 1 | 12 | 17 | |
| GSE20123 | INPP5D | 3635 | 1 | 12 | 17 | |
| GSE43470 | INPP5D | 3635 | 1 | 9 | 33 | |
| GSE46452 | INPP5D | 3635 | 0 | 5 | 54 | |
| GSE47630 | INPP5D | 3635 | 4 | 5 | 31 | |
| GSE54993 | INPP5D | 3635 | 3 | 2 | 65 | |
| GSE54994 | INPP5D | 3635 | 6 | 10 | 37 | |
| GSE60625 | INPP5D | 3635 | 0 | 3 | 8 | |
| GSE74703 | INPP5D | 3635 | 1 | 7 | 28 | |
| GSE74704 | INPP5D | 3635 | 1 | 5 | 14 | |
| TCGA | INPP5D | 3635 | 12 | 28 | 56 |
Total number of gains: 30; Total number of losses: 98; Total Number of normals: 360.
Somatic mutations of INPP5D:
Generating mutation plots.
Highly correlated genes for INPP5D:
Showing top 20/523 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| INPP5D | GIMAP5 | 0.806055 | 4 | 0 | 4 |
| INPP5D | ARHGAP15 | 0.790879 | 4 | 0 | 4 |
| INPP5D | SNX20 | 0.781832 | 6 | 0 | 6 |
| INPP5D | IRF8 | 0.752171 | 11 | 0 | 10 |
| INPP5D | XBP1 | 0.750831 | 3 | 0 | 3 |
| INPP5D | CD37 | 0.748997 | 9 | 0 | 8 |
| INPP5D | TNFAIP8L2 | 0.744056 | 6 | 0 | 6 |
| INPP5D | GIMAP7 | 0.740076 | 8 | 0 | 7 |
| INPP5D | KRT33B | 0.73445 | 3 | 0 | 3 |
| INPP5D | TRG-AS1 | 0.732971 | 4 | 0 | 4 |
| INPP5D | PARP15 | 0.732188 | 5 | 0 | 5 |
| INPP5D | TAGAP | 0.728126 | 6 | 0 | 6 |
| INPP5D | EVI2B | 0.727797 | 11 | 0 | 11 |
| INPP5D | CD48 | 0.724485 | 11 | 0 | 9 |
| INPP5D | ANKRD44 | 0.723925 | 6 | 0 | 6 |
| INPP5D | NCKAP1L | 0.719299 | 10 | 0 | 10 |
| INPP5D | GAPT | 0.716927 | 6 | 0 | 6 |
| INPP5D | DMBT1 | 0.715898 | 3 | 0 | 3 |
| INPP5D | SLAMF6 | 0.714014 | 7 | 0 | 6 |
| INPP5D | GIMAP8 | 0.713064 | 7 | 0 | 7 |
For details and further investigation, click here
