| Full name: FIG4 phosphoinositide 5-phosphatase | Alias Symbol: SAC3|hSac3|dJ249I4.1|ALS11|CMT4J | ||
| Type: protein-coding gene | Cytoband: 6q21 | ||
| Entrez ID: 9896 | HGNC ID: HGNC:16873 | Ensembl Gene: ENSG00000112367 | OMIM ID: 609390 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of FIG4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FIG4 | 9896 | 203656_at | -0.8611 | 0.0331 | |
| GSE20347 | FIG4 | 9896 | 203656_at | -0.8167 | 0.0000 | |
| GSE23400 | FIG4 | 9896 | 203656_at | -0.2925 | 0.0000 | |
| GSE26886 | FIG4 | 9896 | 203656_at | -0.6368 | 0.0018 | |
| GSE29001 | FIG4 | 9896 | 203656_at | -0.5783 | 0.0519 | |
| GSE38129 | FIG4 | 9896 | 203656_at | -0.7286 | 0.0000 | |
| GSE45670 | FIG4 | 9896 | 203656_at | -0.6621 | 0.0004 | |
| GSE53622 | FIG4 | 9896 | 37877 | -0.7738 | 0.0000 | |
| GSE53624 | FIG4 | 9896 | 54755 | -0.8212 | 0.0000 | |
| GSE63941 | FIG4 | 9896 | 203656_at | -1.0540 | 0.0412 | |
| GSE77861 | FIG4 | 9896 | 203656_at | -0.8287 | 0.0028 | |
| GSE97050 | FIG4 | 9896 | A_33_P3337981 | -0.3284 | 0.1785 | |
| SRP007169 | FIG4 | 9896 | RNAseq | -1.0289 | 0.0035 | |
| SRP008496 | FIG4 | 9896 | RNAseq | -0.7354 | 0.0038 | |
| SRP064894 | FIG4 | 9896 | RNAseq | -0.4289 | 0.0013 | |
| SRP133303 | FIG4 | 9896 | RNAseq | -0.5678 | 0.0005 | |
| SRP159526 | FIG4 | 9896 | RNAseq | -0.6945 | 0.0029 | |
| SRP193095 | FIG4 | 9896 | RNAseq | -0.8466 | 0.0000 | |
| SRP219564 | FIG4 | 9896 | RNAseq | -0.5694 | 0.0410 | |
| TCGA | FIG4 | 9896 | RNAseq | -0.2641 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by FIG4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FIG4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FIG4 | 9896 | 2 | 3 | 25 | |
| GSE20123 | FIG4 | 9896 | 2 | 2 | 26 | |
| GSE43470 | FIG4 | 9896 | 3 | 1 | 39 | |
| GSE46452 | FIG4 | 9896 | 2 | 11 | 46 | |
| GSE47630 | FIG4 | 9896 | 9 | 4 | 27 | |
| GSE54993 | FIG4 | 9896 | 3 | 2 | 65 | |
| GSE54994 | FIG4 | 9896 | 8 | 8 | 37 | |
| GSE60625 | FIG4 | 9896 | 0 | 2 | 9 | |
| GSE74703 | FIG4 | 9896 | 2 | 1 | 33 | |
| GSE74704 | FIG4 | 9896 | 0 | 0 | 20 | |
| TCGA | FIG4 | 9896 | 6 | 24 | 66 |
Total number of gains: 37; Total number of losses: 58; Total Number of normals: 393.
Somatic mutations of FIG4:
Generating mutation plots.
Highly correlated genes for FIG4:
Showing top 20/1478 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FIG4 | GALNT11 | 0.779836 | 4 | 0 | 4 |
| FIG4 | ELL3 | 0.760377 | 3 | 0 | 3 |
| FIG4 | SLC35B3 | 0.752694 | 3 | 0 | 3 |
| FIG4 | TRA2A | 0.750188 | 3 | 0 | 3 |
| FIG4 | PAQR8 | 0.736863 | 7 | 0 | 7 |
| FIG4 | TSPAN31 | 0.736139 | 4 | 0 | 4 |
| FIG4 | LIFR | 0.731133 | 5 | 0 | 5 |
| FIG4 | ZCCHC10 | 0.724697 | 3 | 0 | 3 |
| FIG4 | ATP11B | 0.722856 | 4 | 0 | 4 |
| FIG4 | NDUFV3 | 0.721017 | 3 | 0 | 3 |
| FIG4 | GBGT1 | 0.71504 | 3 | 0 | 3 |
| FIG4 | EIF4E3 | 0.712807 | 7 | 0 | 6 |
| FIG4 | CAPN7 | 0.712713 | 7 | 0 | 7 |
| FIG4 | AK9 | 0.711677 | 6 | 0 | 6 |
| FIG4 | FAM149B1 | 0.709774 | 11 | 0 | 10 |
| FIG4 | SMDT1 | 0.70933 | 5 | 0 | 5 |
| FIG4 | CGNL1 | 0.703808 | 7 | 0 | 6 |
| FIG4 | MACROD2 | 0.701111 | 4 | 0 | 4 |
| FIG4 | MAP6 | 0.699871 | 3 | 0 | 3 |
| FIG4 | KBTBD3 | 0.699661 | 3 | 0 | 3 |
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