| Full name: dynactin subunit 2 | Alias Symbol: RBP50|DCTN-50 | ||
| Type: protein-coding gene | Cytoband: 12q13.3 | ||
| Entrez ID: 10540 | HGNC ID: HGNC:2712 | Ensembl Gene: ENSG00000175203 | OMIM ID: 607376 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of DCTN2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DCTN2 | 10540 | 200932_s_at | -0.5356 | 0.0426 | |
| GSE20347 | DCTN2 | 10540 | 200932_s_at | -0.5801 | 0.0000 | |
| GSE23400 | DCTN2 | 10540 | 200932_s_at | -0.3141 | 0.0000 | |
| GSE26886 | DCTN2 | 10540 | 200932_s_at | -0.3207 | 0.0191 | |
| GSE29001 | DCTN2 | 10540 | 200932_s_at | -0.5812 | 0.0132 | |
| GSE38129 | DCTN2 | 10540 | 200932_s_at | -0.3423 | 0.0023 | |
| GSE45670 | DCTN2 | 10540 | 200932_s_at | -0.2660 | 0.0196 | |
| GSE53622 | DCTN2 | 10540 | 14296 | -0.4767 | 0.0000 | |
| GSE53624 | DCTN2 | 10540 | 14296 | -0.2709 | 0.0000 | |
| GSE63941 | DCTN2 | 10540 | 200932_s_at | -0.1007 | 0.7411 | |
| GSE77861 | DCTN2 | 10540 | 200932_s_at | -0.4238 | 0.0339 | |
| GSE97050 | DCTN2 | 10540 | A_23_P360167 | -0.1940 | 0.3274 | |
| SRP007169 | DCTN2 | 10540 | RNAseq | -1.3034 | 0.0000 | |
| SRP008496 | DCTN2 | 10540 | RNAseq | -1.2232 | 0.0000 | |
| SRP064894 | DCTN2 | 10540 | RNAseq | -0.4021 | 0.0091 | |
| SRP133303 | DCTN2 | 10540 | RNAseq | -0.2220 | 0.0099 | |
| SRP159526 | DCTN2 | 10540 | RNAseq | -0.6087 | 0.0023 | |
| SRP193095 | DCTN2 | 10540 | RNAseq | -0.5745 | 0.0000 | |
| SRP219564 | DCTN2 | 10540 | RNAseq | -0.5996 | 0.0016 | |
| TCGA | DCTN2 | 10540 | RNAseq | -0.0998 | 0.0201 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by DCTN2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DCTN2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DCTN2 | 10540 | 7 | 1 | 22 | |
| GSE20123 | DCTN2 | 10540 | 7 | 0 | 23 | |
| GSE43470 | DCTN2 | 10540 | 2 | 0 | 41 | |
| GSE46452 | DCTN2 | 10540 | 8 | 1 | 50 | |
| GSE47630 | DCTN2 | 10540 | 10 | 2 | 28 | |
| GSE54993 | DCTN2 | 10540 | 0 | 5 | 65 | |
| GSE54994 | DCTN2 | 10540 | 4 | 1 | 48 | |
| GSE60625 | DCTN2 | 10540 | 0 | 0 | 11 | |
| GSE74703 | DCTN2 | 10540 | 2 | 0 | 34 | |
| GSE74704 | DCTN2 | 10540 | 5 | 0 | 15 | |
| TCGA | DCTN2 | 10540 | 14 | 10 | 72 |
Total number of gains: 59; Total number of losses: 20; Total Number of normals: 409.
Somatic mutations of DCTN2:
Generating mutation plots.
Highly correlated genes for DCTN2:
Showing top 20/1550 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DCTN2 | ZRANB1 | 0.817191 | 3 | 0 | 3 |
| DCTN2 | UBQLN1 | 0.774847 | 3 | 0 | 3 |
| DCTN2 | FGD4 | 0.75349 | 5 | 0 | 5 |
| DCTN2 | UBE2G2 | 0.752772 | 3 | 0 | 3 |
| DCTN2 | PARD3B | 0.746254 | 3 | 0 | 3 |
| DCTN2 | CNOT4 | 0.745787 | 3 | 0 | 3 |
| DCTN2 | BRK1 | 0.744739 | 6 | 0 | 6 |
| DCTN2 | ALKBH7 | 0.742054 | 5 | 0 | 4 |
| DCTN2 | ICA1L | 0.737265 | 3 | 0 | 3 |
| DCTN2 | ADAM11 | 0.73576 | 4 | 0 | 3 |
| DCTN2 | ZNF304 | 0.734241 | 3 | 0 | 3 |
| DCTN2 | NDUFB2 | 0.730728 | 3 | 0 | 3 |
| DCTN2 | RRAGC | 0.730109 | 3 | 0 | 3 |
| DCTN2 | NOXO1 | 0.728472 | 3 | 0 | 3 |
| DCTN2 | TCEANC2 | 0.726864 | 3 | 0 | 3 |
| DCTN2 | RNF207 | 0.726006 | 3 | 0 | 3 |
| DCTN2 | CPEB4 | 0.722919 | 6 | 0 | 6 |
| DCTN2 | PDK2 | 0.722711 | 3 | 0 | 3 |
| DCTN2 | MRPL44 | 0.722606 | 3 | 0 | 3 |
| DCTN2 | TMEM234 | 0.722198 | 3 | 0 | 3 |
For details and further investigation, click here
