| Full name: HPS5 biogenesis of lysosomal organelles complex 2 subunit 2 | Alias Symbol: BLOC2S2|AIBP63|RU2 | ||
| Type: protein-coding gene | Cytoband: 11p15.1 | ||
| Entrez ID: 11234 | HGNC ID: HGNC:17022 | Ensembl Gene: ENSG00000110756 | OMIM ID: 607521 |
| Drug and gene relationship at DGIdb | |||
Expression of HPS5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HPS5 | 11234 | 204544_at | 0.1009 | 0.8656 | |
| GSE20347 | HPS5 | 11234 | 204544_at | -0.5181 | 0.0036 | |
| GSE23400 | HPS5 | 11234 | 204544_at | 0.1253 | 0.0610 | |
| GSE26886 | HPS5 | 11234 | 204544_at | -0.1652 | 0.5235 | |
| GSE29001 | HPS5 | 11234 | 204544_at | -0.0875 | 0.8295 | |
| GSE38129 | HPS5 | 11234 | 204544_at | -0.1782 | 0.2440 | |
| GSE45670 | HPS5 | 11234 | 204544_at | 0.1464 | 0.3035 | |
| GSE53622 | HPS5 | 11234 | 38346 | 0.0983 | 0.1561 | |
| GSE53624 | HPS5 | 11234 | 38346 | -0.0429 | 0.5945 | |
| GSE63941 | HPS5 | 11234 | 204544_at | -1.3481 | 0.0232 | |
| GSE77861 | HPS5 | 11234 | 204544_at | 0.0965 | 0.6830 | |
| GSE97050 | HPS5 | 11234 | A_23_P98631 | 0.2085 | 0.4609 | |
| SRP007169 | HPS5 | 11234 | RNAseq | -0.5464 | 0.1683 | |
| SRP008496 | HPS5 | 11234 | RNAseq | -0.1194 | 0.6202 | |
| SRP064894 | HPS5 | 11234 | RNAseq | -0.0610 | 0.7966 | |
| SRP133303 | HPS5 | 11234 | RNAseq | 0.1637 | 0.3330 | |
| SRP159526 | HPS5 | 11234 | RNAseq | 0.0743 | 0.7323 | |
| SRP193095 | HPS5 | 11234 | RNAseq | -0.2153 | 0.0185 | |
| SRP219564 | HPS5 | 11234 | RNAseq | 0.3047 | 0.3424 | |
| TCGA | HPS5 | 11234 | RNAseq | 0.0904 | 0.1008 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by HPS5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HPS5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HPS5 | 11234 | 0 | 10 | 20 | |
| GSE20123 | HPS5 | 11234 | 0 | 10 | 20 | |
| GSE43470 | HPS5 | 11234 | 1 | 5 | 37 | |
| GSE46452 | HPS5 | 11234 | 7 | 5 | 47 | |
| GSE47630 | HPS5 | 11234 | 3 | 10 | 27 | |
| GSE54993 | HPS5 | 11234 | 3 | 0 | 67 | |
| GSE54994 | HPS5 | 11234 | 2 | 13 | 38 | |
| GSE60625 | HPS5 | 11234 | 0 | 0 | 11 | |
| GSE74703 | HPS5 | 11234 | 1 | 3 | 32 | |
| GSE74704 | HPS5 | 11234 | 0 | 9 | 11 | |
| TCGA | HPS5 | 11234 | 11 | 29 | 56 |
Total number of gains: 28; Total number of losses: 94; Total Number of normals: 366.
Somatic mutations of HPS5:
Generating mutation plots.
Highly correlated genes for HPS5:
Showing top 20/241 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HPS5 | ZNF638 | 0.817228 | 3 | 0 | 3 |
| HPS5 | RINT1 | 0.779206 | 3 | 0 | 3 |
| HPS5 | SPG7 | 0.770902 | 3 | 0 | 3 |
| HPS5 | TRADD | 0.759652 | 3 | 0 | 3 |
| HPS5 | NUS1 | 0.752528 | 3 | 0 | 3 |
| HPS5 | DDX59 | 0.727723 | 3 | 0 | 3 |
| HPS5 | TTC37 | 0.726193 | 3 | 0 | 3 |
| HPS5 | PMS1 | 0.722753 | 3 | 0 | 3 |
| HPS5 | SKAP2 | 0.722198 | 3 | 0 | 3 |
| HPS5 | MGAT5 | 0.713287 | 3 | 0 | 3 |
| HPS5 | STAMBPL1 | 0.707194 | 4 | 0 | 3 |
| HPS5 | BAZ2B | 0.695921 | 4 | 0 | 4 |
| HPS5 | MTIF2 | 0.693861 | 3 | 0 | 3 |
| HPS5 | THAP6 | 0.689994 | 4 | 0 | 3 |
| HPS5 | CNOT4 | 0.687378 | 3 | 0 | 3 |
| HPS5 | API5 | 0.687343 | 4 | 0 | 3 |
| HPS5 | IL10RB | 0.683256 | 4 | 0 | 3 |
| HPS5 | USP4 | 0.682183 | 4 | 0 | 3 |
| HPS5 | ITGB8 | 0.679256 | 3 | 0 | 3 |
| HPS5 | SAAL1 | 0.675852 | 4 | 0 | 3 |
For details and further investigation, click here
