POLD3

 

Full name: DNA polymerase delta 3, accessory subunit Alias Symbol: P66|KIAA0039|P68|PPP1R128
Type: protein-coding gene Cytoband: 11q13.4
Entrez ID: 10714 HGNC ID: HGNC:20932 Ensembl Gene: ENSG00000077514 OMIM ID: 611415

 

POLD3 involved pathways:

KEGG pathway Description View
hsa05166HTLV-I infection

 

Expression of POLD3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 POLD3 10714 212836_at 0.4438 0.6246
GSE20347 POLD3 10714 212836_at 0.5660 0.0003
GSE23400 POLD3 10714 212836_at 0.6487 0.0000
GSE26886 POLD3 10714 212836_at -1.0518 0.0000
GSE29001 POLD3 10714 212836_at 0.3028 0.2221
GSE38129 POLD3 10714 212836_at 0.4682 0.0000
GSE45670 POLD3 10714 212836_at 0.2961 0.1525
GSE53622 POLD3 10714 106867 0.4240 0.0000
GSE53624 POLD3 10714 106867 0.7088 0.0000
GSE63941 POLD3 10714 212836_at 0.6033 0.3921
GSE77861 POLD3 10714 239816_at -0.0918 0.3514
GSE97050 POLD3 10714 A_32_P182439 0.4121 0.2097
SRP007169 POLD3 10714 RNAseq 0.7558 0.0531
SRP008496 POLD3 10714 RNAseq 1.0347 0.0061
SRP064894 POLD3 10714 RNAseq 0.7909 0.0000
SRP133303 POLD3 10714 RNAseq 0.2307 0.1920
SRP159526 POLD3 10714 RNAseq 0.0249 0.9012
SRP193095 POLD3 10714 RNAseq 0.2067 0.1857
SRP219564 POLD3 10714 RNAseq 0.9219 0.0428
TCGA POLD3 10714 RNAseq 0.1828 0.0070

Upregulated datasets: 1; Downregulated datasets: 1.  

 

Survival by POLD3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of POLD3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 POLD3 10714 6 9 15
GSE20123 POLD3 10714 6 8 16
GSE43470 POLD3 10714 5 4 34
GSE46452 POLD3 10714 7 22 30
GSE47630 POLD3 10714 6 14 20
GSE54993 POLD3 10714 8 3 59
GSE54994 POLD3 10714 8 15 30
GSE60625 POLD3 10714 4 3 4
GSE74703 POLD3 10714 4 3 29
GSE74704 POLD3 10714 4 4 12
TCGA POLD3 10714 23 32 41

Total number of gains: 81; Total number of losses: 117; Total Number of normals: 290.  

 

Somatic mutations of POLD3:

 

Generating mutation plots.

 

Highly correlated genes for POLD3:

 

Showing top 20/85 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
POLD3DDIAS0.69368404
POLD3SPCS20.68956311010
POLD3CLNS1A0.664816908
POLD3XKRX0.636944303
POLD3LIPT20.629118303
POLD3LRR10.600467403
POLD3NARS20.5967371007
POLD3ZNF8130.594925303
POLD3ZNF5510.594163303
POLD3BORA0.588293705
POLD3SKA30.583504
POLD3ATG4C0.57907403
POLD3TMEM1350.578536605
POLD3MND10.574286303
POLD3PPME10.573352806
POLD3PAK10.5650961006
POLD3ALG80.5616771106
POLD3ERCC6L0.558607806
POLD3SPC240.556912504
POLD3ZNF3670.556193503

For details and further investigation, click here