| Full name: protein phosphatase methylesterase 1 | Alias Symbol: PME-1|ABDH19 | ||
| Type: protein-coding gene | Cytoband: 11q13.4 | ||
| Entrez ID: 51400 | HGNC ID: HGNC:30178 | Ensembl Gene: ENSG00000214517 | OMIM ID: 611117 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of PPME1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPME1 | 51400 | 217841_s_at | 0.2118 | 0.7874 | |
| GSE20347 | PPME1 | 51400 | 49077_at | 0.0353 | 0.7762 | |
| GSE23400 | PPME1 | 51400 | 49077_at | 0.2186 | 0.0044 | |
| GSE26886 | PPME1 | 51400 | 49077_at | -0.1946 | 0.3570 | |
| GSE29001 | PPME1 | 51400 | 217841_s_at | 0.1037 | 0.7747 | |
| GSE38129 | PPME1 | 51400 | 49077_at | 0.0962 | 0.3817 | |
| GSE45670 | PPME1 | 51400 | 49077_at | 0.2856 | 0.0354 | |
| GSE53622 | PPME1 | 51400 | 45462 | 0.6431 | 0.0000 | |
| GSE53624 | PPME1 | 51400 | 45462 | 0.4970 | 0.0000 | |
| GSE63941 | PPME1 | 51400 | 49077_at | 0.9245 | 0.0553 | |
| GSE77861 | PPME1 | 51400 | 49077_at | 0.0451 | 0.7260 | |
| GSE97050 | PPME1 | 51400 | A_24_P4705 | 0.4249 | 0.3074 | |
| SRP007169 | PPME1 | 51400 | RNAseq | 0.2048 | 0.6604 | |
| SRP008496 | PPME1 | 51400 | RNAseq | 0.5475 | 0.1103 | |
| SRP064894 | PPME1 | 51400 | RNAseq | 0.4318 | 0.0203 | |
| SRP133303 | PPME1 | 51400 | RNAseq | 0.3904 | 0.1680 | |
| SRP159526 | PPME1 | 51400 | RNAseq | -0.0619 | 0.8517 | |
| SRP193095 | PPME1 | 51400 | RNAseq | 0.3164 | 0.0840 | |
| SRP219564 | PPME1 | 51400 | RNAseq | 0.3913 | 0.3197 | |
| TCGA | PPME1 | 51400 | RNAseq | 0.2268 | 0.0009 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PPME1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPME1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPME1 | 51400 | 6 | 9 | 15 | |
| GSE20123 | PPME1 | 51400 | 6 | 8 | 16 | |
| GSE43470 | PPME1 | 51400 | 6 | 4 | 33 | |
| GSE46452 | PPME1 | 51400 | 8 | 21 | 30 | |
| GSE47630 | PPME1 | 51400 | 6 | 14 | 20 | |
| GSE54993 | PPME1 | 51400 | 8 | 3 | 59 | |
| GSE54994 | PPME1 | 51400 | 8 | 15 | 30 | |
| GSE60625 | PPME1 | 51400 | 4 | 3 | 4 | |
| GSE74703 | PPME1 | 51400 | 5 | 3 | 28 | |
| GSE74704 | PPME1 | 51400 | 4 | 4 | 12 | |
| TCGA | PPME1 | 51400 | 26 | 29 | 41 |
Total number of gains: 87; Total number of losses: 113; Total Number of normals: 288.
Somatic mutations of PPME1:
Generating mutation plots.
Highly correlated genes for PPME1:
Showing top 20/209 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPME1 | FKBP2 | 0.714949 | 4 | 0 | 3 |
| PPME1 | GDAP1 | 0.695666 | 3 | 0 | 3 |
| PPME1 | ACHE | 0.693375 | 3 | 0 | 3 |
| PPME1 | RPS21 | 0.689017 | 3 | 0 | 3 |
| PPME1 | SLC38A7 | 0.688537 | 3 | 0 | 3 |
| PPME1 | BORA | 0.677062 | 4 | 0 | 3 |
| PPME1 | C2CD3 | 0.672376 | 6 | 0 | 5 |
| PPME1 | RNF26 | 0.668385 | 3 | 0 | 3 |
| PPME1 | KHNYN | 0.667898 | 4 | 0 | 3 |
| PPME1 | MID1IP1 | 0.666849 | 3 | 0 | 3 |
| PPME1 | ZNF574 | 0.666436 | 3 | 0 | 3 |
| PPME1 | FAU | 0.666367 | 4 | 0 | 3 |
| PPME1 | MTX1 | 0.6657 | 4 | 0 | 4 |
| PPME1 | POMZP3 | 0.66246 | 3 | 0 | 3 |
| PPME1 | BCL9L | 0.662289 | 3 | 0 | 3 |
| PPME1 | ACTR3 | 0.653609 | 4 | 0 | 4 |
| PPME1 | IFRD2 | 0.653412 | 3 | 0 | 3 |
| PPME1 | MRPL38 | 0.652126 | 4 | 0 | 3 |
| PPME1 | INTS4 | 0.647626 | 7 | 0 | 6 |
| PPME1 | RAP2B | 0.642971 | 4 | 0 | 3 |
For details and further investigation, click here
