| Full name: ALG8 alpha-1,3-glucosyltransferase | Alias Symbol: MGC2840 | ||
| Type: protein-coding gene | Cytoband: 11q14.1 | ||
| Entrez ID: 79053 | HGNC ID: HGNC:23161 | Ensembl Gene: ENSG00000159063 | OMIM ID: 608103 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of ALG8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ALG8 | 79053 | 203545_at | 0.5357 | 0.5691 | |
| GSE20347 | ALG8 | 79053 | 203545_at | 0.2644 | 0.1456 | |
| GSE23400 | ALG8 | 79053 | 203545_at | 0.6076 | 0.0000 | |
| GSE26886 | ALG8 | 79053 | 203545_at | -0.1136 | 0.5209 | |
| GSE29001 | ALG8 | 79053 | 203545_at | 0.1794 | 0.4649 | |
| GSE38129 | ALG8 | 79053 | 203545_at | 0.4812 | 0.0007 | |
| GSE45670 | ALG8 | 79053 | 203545_at | 0.4382 | 0.0374 | |
| GSE53622 | ALG8 | 79053 | 65792 | 0.7241 | 0.0000 | |
| GSE53624 | ALG8 | 79053 | 6679 | 0.5739 | 0.0000 | |
| GSE63941 | ALG8 | 79053 | 203545_at | 0.4379 | 0.3231 | |
| GSE77861 | ALG8 | 79053 | 203545_at | 0.1219 | 0.8295 | |
| GSE97050 | ALG8 | 79053 | A_23_P13554 | 0.6344 | 0.1339 | |
| SRP007169 | ALG8 | 79053 | RNAseq | 0.2268 | 0.5820 | |
| SRP008496 | ALG8 | 79053 | RNAseq | 0.2855 | 0.2436 | |
| SRP064894 | ALG8 | 79053 | RNAseq | 0.5163 | 0.0030 | |
| SRP133303 | ALG8 | 79053 | RNAseq | 0.2708 | 0.1392 | |
| SRP159526 | ALG8 | 79053 | RNAseq | 0.2327 | 0.5233 | |
| SRP193095 | ALG8 | 79053 | RNAseq | 0.0738 | 0.6790 | |
| SRP219564 | ALG8 | 79053 | RNAseq | 0.7564 | 0.0609 | |
| TCGA | ALG8 | 79053 | RNAseq | 0.0995 | 0.1647 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ALG8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ALG8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ALG8 | 79053 | 3 | 10 | 17 | |
| GSE20123 | ALG8 | 79053 | 3 | 9 | 18 | |
| GSE43470 | ALG8 | 79053 | 3 | 5 | 35 | |
| GSE46452 | ALG8 | 79053 | 7 | 22 | 30 | |
| GSE47630 | ALG8 | 79053 | 4 | 17 | 19 | |
| GSE54993 | ALG8 | 79053 | 8 | 2 | 60 | |
| GSE54994 | ALG8 | 79053 | 5 | 17 | 31 | |
| GSE60625 | ALG8 | 79053 | 4 | 3 | 4 | |
| GSE74703 | ALG8 | 79053 | 2 | 4 | 30 | |
| GSE74704 | ALG8 | 79053 | 3 | 5 | 12 | |
| TCGA | ALG8 | 79053 | 18 | 32 | 46 |
Total number of gains: 60; Total number of losses: 126; Total Number of normals: 302.
Somatic mutations of ALG8:
Generating mutation plots.
Highly correlated genes for ALG8:
Showing top 20/661 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ALG8 | INTS4 | 0.798272 | 8 | 0 | 8 |
| ALG8 | PPP2R1B | 0.772878 | 3 | 0 | 3 |
| ALG8 | KHNYN | 0.766865 | 3 | 0 | 3 |
| ALG8 | CLNS1A | 0.758983 | 13 | 0 | 13 |
| ALG8 | PAK2 | 0.756038 | 3 | 0 | 3 |
| ALG8 | ANKS6 | 0.741914 | 3 | 0 | 3 |
| ALG8 | NCOA7 | 0.730812 | 3 | 0 | 3 |
| ALG8 | NARS2 | 0.727737 | 13 | 0 | 12 |
| ALG8 | EMB | 0.711641 | 4 | 0 | 3 |
| ALG8 | CIAO1 | 0.706077 | 3 | 0 | 3 |
| ALG8 | LIPT2 | 0.705525 | 3 | 0 | 3 |
| ALG8 | SLC35B2 | 0.703441 | 3 | 0 | 3 |
| ALG8 | SFT2D3 | 0.700113 | 3 | 0 | 3 |
| ALG8 | SLC40A1 | 0.695248 | 3 | 0 | 3 |
| ALG8 | TREM2 | 0.684643 | 4 | 0 | 3 |
| ALG8 | MAD2L2 | 0.677297 | 3 | 0 | 3 |
| ALG8 | TCTEX1D2 | 0.674602 | 3 | 0 | 3 |
| ALG8 | LTV1 | 0.67239 | 3 | 0 | 3 |
| ALG8 | DHODH | 0.671352 | 4 | 0 | 3 |
| ALG8 | ZSCAN29 | 0.669133 | 4 | 0 | 3 |
For details and further investigation, click here
