| Full name: DNA polymerase gamma, catalytic subunit | Alias Symbol: POLG1|POLGA | ||
| Type: protein-coding gene | Cytoband: 15q26.1 | ||
| Entrez ID: 5428 | HGNC ID: HGNC:9179 | Ensembl Gene: ENSG00000140521 | OMIM ID: 174763 |
| Related drugs: VALPROIC ACID... [more] | |||
Screen Evidence:
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Expression of POLG:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | POLG | 5428 | 203366_at | 0.2369 | 0.4613 | |
| GSE20347 | POLG | 5428 | 203366_at | 0.2065 | 0.3930 | |
| GSE23400 | POLG | 5428 | 217636_at | -0.1471 | 0.0000 | |
| GSE26886 | POLG | 5428 | 203366_at | 0.1782 | 0.4429 | |
| GSE29001 | POLG | 5428 | 203366_at | 0.1377 | 0.5103 | |
| GSE38129 | POLG | 5428 | 203366_at | 0.2028 | 0.2463 | |
| GSE45670 | POLG | 5428 | 203366_at | 0.1926 | 0.3777 | |
| GSE63941 | POLG | 5428 | 203366_at | 0.0713 | 0.8878 | |
| GSE77861 | POLG | 5428 | 203366_at | -0.0071 | 0.9706 | |
| GSE97050 | POLG | 5428 | A_23_P3355 | 0.4327 | 0.1703 | |
| SRP007169 | POLG | 5428 | RNAseq | 0.0191 | 0.9616 | |
| SRP008496 | POLG | 5428 | RNAseq | -0.4031 | 0.1738 | |
| SRP064894 | POLG | 5428 | RNAseq | 0.1499 | 0.1335 | |
| SRP133303 | POLG | 5428 | RNAseq | 0.2291 | 0.2082 | |
| SRP159526 | POLG | 5428 | RNAseq | 0.2414 | 0.2766 | |
| SRP193095 | POLG | 5428 | RNAseq | 0.3354 | 0.0001 | |
| SRP219564 | POLG | 5428 | RNAseq | 0.2955 | 0.4480 | |
| TCGA | POLG | 5428 | RNAseq | 0.0163 | 0.7247 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by POLG expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of POLG:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | POLG | 5428 | 8 | 3 | 19 | |
| GSE20123 | POLG | 5428 | 8 | 3 | 19 | |
| GSE43470 | POLG | 5428 | 5 | 4 | 34 | |
| GSE46452 | POLG | 5428 | 3 | 7 | 49 | |
| GSE47630 | POLG | 5428 | 8 | 11 | 21 | |
| GSE54993 | POLG | 5428 | 4 | 6 | 60 | |
| GSE54994 | POLG | 5428 | 7 | 6 | 40 | |
| GSE60625 | POLG | 5428 | 4 | 0 | 7 | |
| GSE74703 | POLG | 5428 | 4 | 3 | 29 | |
| GSE74704 | POLG | 5428 | 4 | 2 | 14 | |
| TCGA | POLG | 5428 | 17 | 12 | 67 |
Total number of gains: 72; Total number of losses: 57; Total Number of normals: 359.
Somatic mutations of POLG:
Generating mutation plots.
Highly correlated genes for POLG:
Showing top 20/149 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| POLG | PPP2R1B | 0.828357 | 3 | 0 | 3 |
| POLG | PLA2G4A | 0.782374 | 3 | 0 | 3 |
| POLG | PSMG3 | 0.763957 | 3 | 0 | 3 |
| POLG | AQR | 0.76093 | 5 | 0 | 5 |
| POLG | C1orf131 | 0.751888 | 3 | 0 | 3 |
| POLG | TAP2 | 0.742964 | 3 | 0 | 3 |
| POLG | GPANK1 | 0.741422 | 3 | 0 | 3 |
| POLG | TGDS | 0.739492 | 3 | 0 | 3 |
| POLG | ELOVL7 | 0.733767 | 3 | 0 | 3 |
| POLG | EIF2AK4 | 0.733429 | 3 | 0 | 3 |
| POLG | KCTD15 | 0.727579 | 3 | 0 | 3 |
| POLG | RBM34 | 0.725239 | 3 | 0 | 3 |
| POLG | EMB | 0.717807 | 3 | 0 | 3 |
| POLG | GSTCD | 0.711255 | 3 | 0 | 3 |
| POLG | TRUB1 | 0.705414 | 3 | 0 | 3 |
| POLG | TREM2 | 0.705047 | 3 | 0 | 3 |
| POLG | GTPBP8 | 0.700959 | 3 | 0 | 3 |
| POLG | DDX55 | 0.699634 | 3 | 0 | 3 |
| POLG | EIF5B | 0.698511 | 3 | 0 | 3 |
| POLG | MCCC2 | 0.696197 | 3 | 0 | 3 |
For details and further investigation, click here
