| Full name: proteasome maturation protein | Alias Symbol: HSPC014|UMP1 | ||
| Type: protein-coding gene | Cytoband: 13q12.3 | ||
| Entrez ID: 51371 | HGNC ID: HGNC:20330 | Ensembl Gene: ENSG00000132963 | OMIM ID: 613386 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of POMP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | POMP | 51371 | 217769_s_at | 0.0120 | 0.9787 | |
| GSE20347 | POMP | 51371 | 217769_s_at | -0.2814 | 0.1035 | |
| GSE23400 | POMP | 51371 | 217769_s_at | 0.1212 | 0.0495 | |
| GSE26886 | POMP | 51371 | 217769_s_at | 0.1942 | 0.1683 | |
| GSE29001 | POMP | 51371 | 217769_s_at | -0.3289 | 0.2593 | |
| GSE38129 | POMP | 51371 | 217769_s_at | -0.0834 | 0.5005 | |
| GSE45670 | POMP | 51371 | 217769_s_at | 0.1133 | 0.3262 | |
| GSE53622 | POMP | 51371 | 61525 | -0.0942 | 0.2679 | |
| GSE53624 | POMP | 51371 | 61525 | 0.1602 | 0.1883 | |
| GSE63941 | POMP | 51371 | 217769_s_at | -0.0888 | 0.8033 | |
| GSE77861 | POMP | 51371 | 217769_s_at | -0.0645 | 0.7524 | |
| GSE97050 | POMP | 51371 | A_33_P3240263 | 0.0805 | 0.6969 | |
| SRP007169 | POMP | 51371 | RNAseq | -0.6515 | 0.0377 | |
| SRP008496 | POMP | 51371 | RNAseq | -0.5426 | 0.0266 | |
| SRP064894 | POMP | 51371 | RNAseq | 0.3475 | 0.1170 | |
| SRP133303 | POMP | 51371 | RNAseq | 0.2513 | 0.1360 | |
| SRP159526 | POMP | 51371 | RNAseq | 0.1457 | 0.7450 | |
| SRP193095 | POMP | 51371 | RNAseq | -0.4267 | 0.0105 | |
| SRP219564 | POMP | 51371 | RNAseq | -0.2194 | 0.5944 | |
| TCGA | POMP | 51371 | RNAseq | 0.1217 | 0.0212 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by POMP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of POMP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | POMP | 51371 | 1 | 13 | 16 | |
| GSE20123 | POMP | 51371 | 1 | 12 | 17 | |
| GSE43470 | POMP | 51371 | 2 | 12 | 29 | |
| GSE46452 | POMP | 51371 | 0 | 33 | 26 | |
| GSE47630 | POMP | 51371 | 3 | 26 | 11 | |
| GSE54993 | POMP | 51371 | 12 | 2 | 56 | |
| GSE54994 | POMP | 51371 | 2 | 13 | 38 | |
| GSE60625 | POMP | 51371 | 0 | 3 | 8 | |
| GSE74703 | POMP | 51371 | 2 | 9 | 25 | |
| GSE74704 | POMP | 51371 | 0 | 10 | 10 | |
| TCGA | POMP | 51371 | 8 | 38 | 50 |
Total number of gains: 31; Total number of losses: 171; Total Number of normals: 286.
Somatic mutations of POMP:
Generating mutation plots.
Highly correlated genes for POMP:
Showing top 20/338 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| POMP | MAN2B2 | 0.766996 | 3 | 0 | 3 |
| POMP | ANAPC4 | 0.739669 | 3 | 0 | 3 |
| POMP | C2orf76 | 0.708569 | 3 | 0 | 3 |
| POMP | RPL22L1 | 0.705614 | 3 | 0 | 3 |
| POMP | CHCHD7 | 0.702107 | 3 | 0 | 3 |
| POMP | ZSCAN12 | 0.701421 | 4 | 0 | 4 |
| POMP | EXOC8 | 0.693256 | 4 | 0 | 4 |
| POMP | SLC37A3 | 0.686218 | 3 | 0 | 3 |
| POMP | KIF16B | 0.685639 | 3 | 0 | 3 |
| POMP | ZNF7 | 0.683283 | 3 | 0 | 3 |
| POMP | IK | 0.681617 | 3 | 0 | 3 |
| POMP | PDZD11 | 0.678987 | 5 | 0 | 4 |
| POMP | SGMS1 | 0.67857 | 3 | 0 | 3 |
| POMP | SEC22A | 0.670745 | 3 | 0 | 3 |
| POMP | RAD23B | 0.667951 | 5 | 0 | 4 |
| POMP | UBE2Q2 | 0.666907 | 4 | 0 | 3 |
| POMP | TP53BP2 | 0.666278 | 3 | 0 | 3 |
| POMP | TRIM5 | 0.664988 | 3 | 0 | 3 |
| POMP | PET117 | 0.656544 | 3 | 0 | 3 |
| POMP | UCHL5 | 0.65345 | 6 | 0 | 5 |
For details and further investigation, click here
