| Full name: semaphorin 3A | Alias Symbol: SEMA1|SemD|coll-1|Hsema-I | ||
| Type: protein-coding gene | Cytoband: 7q21.11 | ||
| Entrez ID: 10371 | HGNC ID: HGNC:10723 | Ensembl Gene: ENSG00000075213 | OMIM ID: 603961 |
| Drug and gene relationship at DGIdb | |||
SEMA3A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04360 | Axon guidance |
Expression of SEMA3A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SEMA3A | 10371 | 206805_at | -0.7302 | 0.4965 | |
| GSE20347 | SEMA3A | 10371 | 206805_at | 0.3082 | 0.1258 | |
| GSE23400 | SEMA3A | 10371 | 206805_at | -0.1780 | 0.0122 | |
| GSE26886 | SEMA3A | 10371 | 206805_at | 0.9640 | 0.0000 | |
| GSE29001 | SEMA3A | 10371 | 206805_at | 0.0676 | 0.7491 | |
| GSE38129 | SEMA3A | 10371 | 206805_at | -0.2407 | 0.4549 | |
| GSE45670 | SEMA3A | 10371 | 206805_at | -0.0976 | 0.8498 | |
| GSE53622 | SEMA3A | 10371 | 55605 | -0.5044 | 0.0184 | |
| GSE53624 | SEMA3A | 10371 | 55605 | 0.0954 | 0.6543 | |
| GSE63941 | SEMA3A | 10371 | 206805_at | -1.1207 | 0.4881 | |
| GSE77861 | SEMA3A | 10371 | 206805_at | 0.2754 | 0.2848 | |
| GSE97050 | SEMA3A | 10371 | A_24_P192301 | -0.4070 | 0.5726 | |
| SRP007169 | SEMA3A | 10371 | RNAseq | 3.5775 | 0.0000 | |
| SRP008496 | SEMA3A | 10371 | RNAseq | 3.3981 | 0.0000 | |
| SRP064894 | SEMA3A | 10371 | RNAseq | 0.2903 | 0.3354 | |
| SRP133303 | SEMA3A | 10371 | RNAseq | 1.0920 | 0.0010 | |
| SRP159526 | SEMA3A | 10371 | RNAseq | 0.1211 | 0.7844 | |
| SRP193095 | SEMA3A | 10371 | RNAseq | 2.3447 | 0.0000 | |
| SRP219564 | SEMA3A | 10371 | RNAseq | 0.0274 | 0.9789 | |
| TCGA | SEMA3A | 10371 | RNAseq | -0.0585 | 0.7651 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by SEMA3A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SEMA3A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SEMA3A | 10371 | 12 | 1 | 17 | |
| GSE20123 | SEMA3A | 10371 | 11 | 1 | 18 | |
| GSE43470 | SEMA3A | 10371 | 4 | 1 | 38 | |
| GSE46452 | SEMA3A | 10371 | 11 | 0 | 48 | |
| GSE47630 | SEMA3A | 10371 | 7 | 3 | 30 | |
| GSE54993 | SEMA3A | 10371 | 1 | 7 | 62 | |
| GSE54994 | SEMA3A | 10371 | 16 | 3 | 34 | |
| GSE60625 | SEMA3A | 10371 | 0 | 0 | 11 | |
| GSE74703 | SEMA3A | 10371 | 3 | 1 | 32 | |
| GSE74704 | SEMA3A | 10371 | 7 | 1 | 12 | |
| TCGA | SEMA3A | 10371 | 47 | 5 | 44 |
Total number of gains: 119; Total number of losses: 23; Total Number of normals: 346.
Somatic mutations of SEMA3A:
Generating mutation plots.
Highly correlated genes for SEMA3A:
Showing top 20/862 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SEMA3A | SNAPC4 | 0.810643 | 3 | 0 | 3 |
| SEMA3A | RBMX2 | 0.762295 | 3 | 0 | 3 |
| SEMA3A | SYNC | 0.762222 | 6 | 0 | 6 |
| SEMA3A | INMT | 0.761361 | 3 | 0 | 3 |
| SEMA3A | LIMS2 | 0.761312 | 5 | 0 | 5 |
| SEMA3A | HMCN1 | 0.755299 | 6 | 0 | 6 |
| SEMA3A | MYOM1 | 0.754031 | 4 | 0 | 4 |
| SEMA3A | LNP1 | 0.750731 | 3 | 0 | 3 |
| SEMA3A | XKR4 | 0.748113 | 3 | 0 | 3 |
| SEMA3A | ZCRB1 | 0.747896 | 3 | 0 | 3 |
| SEMA3A | C11orf96 | 0.745698 | 3 | 0 | 3 |
| SEMA3A | SGIP1 | 0.745336 | 4 | 0 | 4 |
| SEMA3A | NACC2 | 0.743577 | 5 | 0 | 5 |
| SEMA3A | KIF5C | 0.742354 | 5 | 0 | 5 |
| SEMA3A | DNAJC18 | 0.737343 | 3 | 0 | 3 |
| SEMA3A | ANKRD40 | 0.734221 | 4 | 0 | 3 |
| SEMA3A | KCNMB1 | 0.734054 | 5 | 0 | 5 |
| SEMA3A | DOCK11 | 0.732259 | 4 | 0 | 4 |
| SEMA3A | ANGPT1 | 0.73111 | 6 | 0 | 6 |
| SEMA3A | ST13 | 0.731085 | 3 | 0 | 3 |
For details and further investigation, click here
