| Full name: PTPRF interacting protein alpha 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1q32.1 | ||
| Entrez ID: 8497 | HGNC ID: HGNC:9248 | Ensembl Gene: ENSG00000143847 | OMIM ID: 603145 |
| Drug and gene relationship at DGIdb | |||
Expression of PPFIA4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPFIA4 | 8497 | 214978_s_at | -0.0793 | 0.8680 | |
| GSE20347 | PPFIA4 | 8497 | 214978_s_at | 0.1227 | 0.1718 | |
| GSE23400 | PPFIA4 | 8497 | 214978_s_at | 0.1337 | 0.0473 | |
| GSE26886 | PPFIA4 | 8497 | 214978_s_at | -0.0737 | 0.6026 | |
| GSE29001 | PPFIA4 | 8497 | 214978_s_at | 0.5244 | 0.0759 | |
| GSE38129 | PPFIA4 | 8497 | 214978_s_at | 0.2520 | 0.0218 | |
| GSE45670 | PPFIA4 | 8497 | 214978_s_at | 0.2683 | 0.2773 | |
| GSE53622 | PPFIA4 | 8497 | 69774 | 0.3026 | 0.0003 | |
| GSE53624 | PPFIA4 | 8497 | 69774 | 0.5231 | 0.0000 | |
| GSE63941 | PPFIA4 | 8497 | 214978_s_at | -0.1837 | 0.6379 | |
| GSE77861 | PPFIA4 | 8497 | 214978_s_at | 0.0381 | 0.8945 | |
| GSE97050 | PPFIA4 | A_21_P0013956 | -0.1993 | 0.3408 | ||
| SRP064894 | PPFIA4 | 8497 | RNAseq | 0.3131 | 0.3618 | |
| SRP133303 | PPFIA4 | 8497 | RNAseq | 1.2569 | 0.0023 | |
| SRP159526 | PPFIA4 | 8497 | RNAseq | 1.6620 | 0.0277 | |
| SRP219564 | PPFIA4 | 8497 | RNAseq | -0.2288 | 0.7388 | |
| TCGA | PPFIA4 | 8497 | RNAseq | 1.0016 | 0.0002 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by PPFIA4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPFIA4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPFIA4 | 8497 | 11 | 0 | 19 | |
| GSE20123 | PPFIA4 | 8497 | 11 | 0 | 19 | |
| GSE43470 | PPFIA4 | 8497 | 6 | 0 | 37 | |
| GSE46452 | PPFIA4 | 8497 | 3 | 1 | 55 | |
| GSE47630 | PPFIA4 | 8497 | 14 | 0 | 26 | |
| GSE54993 | PPFIA4 | 8497 | 0 | 6 | 64 | |
| GSE54994 | PPFIA4 | 8497 | 15 | 0 | 38 | |
| GSE60625 | PPFIA4 | 8497 | 0 | 0 | 11 | |
| GSE74703 | PPFIA4 | 8497 | 6 | 0 | 30 | |
| GSE74704 | PPFIA4 | 8497 | 5 | 0 | 15 | |
| TCGA | PPFIA4 | 8497 | 44 | 4 | 48 |
Total number of gains: 115; Total number of losses: 11; Total Number of normals: 362.
Somatic mutations of PPFIA4:
Generating mutation plots.
Highly correlated genes for PPFIA4:
Showing top 20/23 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPFIA4 | IGFL2 | 0.772072 | 3 | 0 | 3 |
| PPFIA4 | CHGB | 0.760309 | 3 | 0 | 3 |
| PPFIA4 | SLC2A6 | 0.728414 | 3 | 0 | 3 |
| PPFIA4 | ESPNL | 0.708678 | 3 | 0 | 3 |
| PPFIA4 | FMR1NB | 0.663572 | 3 | 0 | 3 |
| PPFIA4 | JAKMIP1 | 0.659416 | 3 | 0 | 3 |
| PPFIA4 | IL12RB2 | 0.633456 | 5 | 0 | 3 |
| PPFIA4 | GPN2 | 0.595725 | 3 | 0 | 3 |
| PPFIA4 | RWDD3 | 0.595675 | 4 | 0 | 3 |
| PPFIA4 | HOXB5 | 0.58082 | 4 | 0 | 3 |
| PPFIA4 | LRRC6 | 0.57795 | 3 | 0 | 3 |
| PPFIA4 | PLXNA3 | 0.577517 | 4 | 0 | 3 |
| PPFIA4 | STRA6 | 0.574711 | 4 | 0 | 3 |
| PPFIA4 | NCALD | 0.571986 | 4 | 0 | 3 |
| PPFIA4 | GPR52 | 0.566764 | 4 | 0 | 3 |
| PPFIA4 | SLC30A3 | 0.557453 | 4 | 0 | 3 |
| PPFIA4 | STAC3 | 0.545334 | 5 | 0 | 3 |
| PPFIA4 | MANBA | 0.541974 | 3 | 0 | 3 |
| PPFIA4 | PMEPA1 | 0.529137 | 6 | 0 | 3 |
| PPFIA4 | CRABP1 | 0.528502 | 6 | 0 | 3 |
For details and further investigation, click here
