| Full name: actin related protein 3 | Alias Symbol: ARP3 | ||
| Type: protein-coding gene | Cytoband: 2q14.1 | ||
| Entrez ID: 10096 | HGNC ID: HGNC:170 | Ensembl Gene: ENSG00000115091 | OMIM ID: 604222 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of ACTR3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ACTR3 | 10096 | 213101_s_at | 0.1242 | 0.6892 | |
| GSE20347 | ACTR3 | 10096 | 213101_s_at | -0.2786 | 0.0237 | |
| GSE23400 | ACTR3 | 10096 | 213101_s_at | 0.0605 | 0.2867 | |
| GSE26886 | ACTR3 | 10096 | 213101_s_at | -0.4173 | 0.0000 | |
| GSE29001 | ACTR3 | 10096 | 213101_s_at | -0.0913 | 0.4360 | |
| GSE38129 | ACTR3 | 10096 | 213101_s_at | 0.0336 | 0.8474 | |
| GSE45670 | ACTR3 | 10096 | 213101_s_at | 0.1588 | 0.0806 | |
| GSE63941 | ACTR3 | 10096 | 213101_s_at | -0.1932 | 0.4733 | |
| GSE77861 | ACTR3 | 10096 | 213101_s_at | -0.0133 | 0.9627 | |
| GSE97050 | ACTR3 | A_21_P0014389 | 0.0924 | 0.6903 | ||
| SRP007169 | ACTR3 | 10096 | RNAseq | -0.6021 | 0.1094 | |
| SRP008496 | ACTR3 | 10096 | RNAseq | -0.2375 | 0.3556 | |
| SRP064894 | ACTR3 | 10096 | RNAseq | -0.4888 | 0.0060 | |
| SRP133303 | ACTR3 | 10096 | RNAseq | 0.0724 | 0.6347 | |
| SRP159526 | ACTR3 | 10096 | RNAseq | -0.1717 | 0.6609 | |
| SRP193095 | ACTR3 | 10096 | RNAseq | -0.4662 | 0.0007 | |
| SRP219564 | ACTR3 | 10096 | RNAseq | -0.6693 | 0.0598 | |
| TCGA | ACTR3 | 10096 | RNAseq | 0.1600 | 0.0002 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ACTR3 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of ACTR3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ACTR3 | 10096 | 6 | 2 | 22 | |
| GSE20123 | ACTR3 | 10096 | 6 | 2 | 22 | |
| GSE43470 | ACTR3 | 10096 | 3 | 1 | 39 | |
| GSE46452 | ACTR3 | 10096 | 1 | 4 | 54 | |
| GSE47630 | ACTR3 | 10096 | 6 | 0 | 34 | |
| GSE54993 | ACTR3 | 10096 | 0 | 6 | 64 | |
| GSE54994 | ACTR3 | 10096 | 11 | 0 | 42 | |
| GSE60625 | ACTR3 | 10096 | 0 | 3 | 8 | |
| GSE74703 | ACTR3 | 10096 | 3 | 1 | 32 | |
| GSE74704 | ACTR3 | 10096 | 2 | 2 | 16 | |
| TCGA | ACTR3 | 10096 | 31 | 5 | 60 |
Total number of gains: 69; Total number of losses: 26; Total Number of normals: 393.
Somatic mutations of ACTR3:
Generating mutation plots.
Highly correlated genes for ACTR3:
Showing top 20/490 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ACTR3 | RIPK3 | 0.821485 | 3 | 0 | 3 |
| ACTR3 | CBLC | 0.819669 | 4 | 0 | 4 |
| ACTR3 | GLUD2 | 0.793804 | 3 | 0 | 3 |
| ACTR3 | ABCC4 | 0.77292 | 3 | 0 | 3 |
| ACTR3 | MKKS | 0.751993 | 3 | 0 | 3 |
| ACTR3 | TSPAN17 | 0.744187 | 4 | 0 | 4 |
| ACTR3 | RAB3D | 0.742238 | 3 | 0 | 3 |
| ACTR3 | GRPEL2 | 0.733947 | 3 | 0 | 3 |
| ACTR3 | EXOC6B | 0.733098 | 3 | 0 | 3 |
| ACTR3 | MLKL | 0.730125 | 3 | 0 | 3 |
| ACTR3 | BAIAP2L1 | 0.724253 | 3 | 0 | 3 |
| ACTR3 | PPP2CA | 0.718971 | 4 | 0 | 4 |
| ACTR3 | MPZL3 | 0.714787 | 3 | 0 | 3 |
| ACTR3 | SNX20 | 0.710805 | 3 | 0 | 3 |
| ACTR3 | RAB2A | 0.710265 | 4 | 0 | 3 |
| ACTR3 | NDUFS3 | 0.708904 | 3 | 0 | 3 |
| ACTR3 | NT5C2 | 0.708807 | 3 | 0 | 3 |
| ACTR3 | MYD88 | 0.708373 | 6 | 0 | 6 |
| ACTR3 | PLEKHG1 | 0.707625 | 4 | 0 | 3 |
| ACTR3 | HAS3 | 0.706541 | 3 | 0 | 3 |
For details and further investigation, click here
