PRKACA

 

Full name: protein kinase cAMP-activated catalytic subunit alpha Alias Symbol: PKACa
Type: protein-coding gene Cytoband: 19p13.1
Entrez ID: 5566 HGNC ID: HGNC:9380 Ensembl Gene: ENSG00000072062 OMIM ID: 601639
Drug and gene relationship at DGIdb
Screen Evidence:

 

PRKACA involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04014Ras signaling pathway
hsa04020Calcium signaling pathway
hsa04024cAMP signaling pathway
hsa04062Chemokine signaling pathway
hsa04114Oocyte meiosis
hsa04211Longevity regulating pathway - mammal
hsa04213Longevity regulating pathway - multiple species
hsa04261Adrenergic signaling in cardiomyocytes
hsa04270Vascular smooth muscle contraction
hsa04310Wnt signaling pathway
hsa04340Hedgehog signaling pathway
hsa04540Gap junction
hsa04611Platelet activation
hsa04713Circadian entrainment
hsa04720Long-term potentiation
hsa04723Retrograde endocannabinoid signaling
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04726Serotonergic synapse
hsa04727GABAergic synapse
hsa04728Dopaminergic synapse
hsa04740Olfactory transduction
hsa04742Taste transduction
hsa04750Inflammatory mediator regulation of TRP channels
hsa04910Insulin signaling pathway
hsa04911Insulin secretion
hsa04912GnRH signaling pathway
hsa04913Ovarian steroidogenesis
hsa04914Progesterone-mediated oocyte maturation
hsa04915Estrogen signaling pathway
hsa04916Melanogenesis
hsa04918Thyroid hormone synthesis
hsa04919Thyroid hormone signaling pathway
hsa04921Oxytocin signaling pathway
hsa04922Glucagon signaling pathway
hsa04923Regulation of lipolysis in adipocytes
hsa04924Renin secretion
hsa04925Aldosterone synthesis and secretion
hsa04961Endocrine and other factor-regulated calcium reabsorption
hsa04962Vasopressin-regulated water reabsorption
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04976Bile secretion
hsa05012Parkinson's disease
hsa05020Prion diseases
hsa05030Cocaine addiction
hsa05031Amphetamine addiction
hsa05032Morphine addiction
hsa05034Alcoholism
hsa05110Vibrio cholerae infection
hsa05166HTLV-I infection
hsa05205Proteoglycans in cancer

 

Expression of PRKACA:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PRKACA 5566 202801_at 0.0193 0.9722
GSE20347 PRKACA 5566 202801_at -0.0017 0.9911
GSE23400 PRKACA 5566 202801_at 0.0199 0.7499
GSE26886 PRKACA 5566 202801_at 0.3246 0.0395
GSE29001 PRKACA 5566 202801_at -0.0958 0.7458
GSE38129 PRKACA 5566 202801_at -0.2307 0.0771
GSE45670 PRKACA 5566 202801_at 0.0599 0.5218
GSE53622 PRKACA 5566 49447 -0.1735 0.0099
GSE53624 PRKACA 5566 49447 0.1947 0.0051
GSE63941 PRKACA 5566 202801_at 0.0052 0.9915
GSE77861 PRKACA 5566 202801_at 0.1096 0.6816
GSE97050 PRKACA 5566 A_24_P399630 -0.1461 0.6118
SRP007169 PRKACA 5566 RNAseq -0.0183 0.9624
SRP008496 PRKACA 5566 RNAseq -0.1715 0.4420
SRP064894 PRKACA 5566 RNAseq 0.3627 0.0649
SRP133303 PRKACA 5566 RNAseq -0.1252 0.3134
SRP159526 PRKACA 5566 RNAseq 0.0001 0.9997
SRP193095 PRKACA 5566 RNAseq 0.2547 0.0900
SRP219564 PRKACA 5566 RNAseq 0.2326 0.5417
TCGA PRKACA 5566 RNAseq -0.0004 0.9928

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by PRKACA expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PRKACA:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PRKACA 5566 4 2 24
GSE20123 PRKACA 5566 3 1 26
GSE43470 PRKACA 5566 2 6 35
GSE46452 PRKACA 5566 47 1 11
GSE47630 PRKACA 5566 4 7 29
GSE54993 PRKACA 5566 15 4 51
GSE54994 PRKACA 5566 6 13 34
GSE60625 PRKACA 5566 9 0 2
GSE74703 PRKACA 5566 2 4 30
GSE74704 PRKACA 5566 0 1 19
TCGA PRKACA 5566 20 11 65

Total number of gains: 112; Total number of losses: 50; Total Number of normals: 326.  

 

Somatic mutations of PRKACA:

 

Generating mutation plots.

 

Highly correlated genes for PRKACA:

 

Showing top 20/689 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PRKACAC17orf670.774791303
PRKACAPDE5A0.764431303
PRKACAPDE9A0.748802303
PRKACABSN0.745172303
PRKACAGFRA10.744519303
PRKACAZFAND30.736501505
PRKACASPNS10.73524303
PRKACASPHK20.731643404
PRKACAPDK20.731632303
PRKACAZBTB220.730918403
PRKACATRIM470.729348404
PRKACAZNF7870.729143404
PRKACADNHD10.728906303
PRKACAST3GAL20.727701303
PRKACAPHKG20.723483303
PRKACAFAM122C0.723035303
PRKACAZNF286A0.720358303
PRKACADCHS20.718308303
PRKACAFN3K0.717494303
PRKACAGMPR0.717372303

For details and further investigation, click here