| Full name: inositol polyphosphate-1-phosphatase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2q32.2 | ||
| Entrez ID: 3628 | HGNC ID: HGNC:6071 | Ensembl Gene: ENSG00000151689 | OMIM ID: 147263 |
| Drug and gene relationship at DGIdb | |||
Expression of INPP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | INPP1 | 3628 | 202794_at | -0.4509 | 0.3862 | |
| GSE20347 | INPP1 | 3628 | 202794_at | -1.6715 | 0.0000 | |
| GSE23400 | INPP1 | 3628 | 202794_at | -1.0512 | 0.0000 | |
| GSE26886 | INPP1 | 3628 | 202794_at | -2.8597 | 0.0000 | |
| GSE29001 | INPP1 | 3628 | 202794_at | -0.9615 | 0.0019 | |
| GSE38129 | INPP1 | 3628 | 202794_at | -1.0783 | 0.0002 | |
| GSE45670 | INPP1 | 3628 | 202794_at | -0.6312 | 0.0376 | |
| GSE53622 | INPP1 | 3628 | 19156 | -1.1963 | 0.0000 | |
| GSE53624 | INPP1 | 3628 | 19156 | -1.7298 | 0.0000 | |
| GSE63941 | INPP1 | 3628 | 202794_at | -0.6327 | 0.5607 | |
| GSE77861 | INPP1 | 3628 | 202794_at | -1.6716 | 0.0017 | |
| GSE97050 | INPP1 | 3628 | A_32_P44453 | -0.4166 | 0.4853 | |
| SRP007169 | INPP1 | 3628 | RNAseq | -2.4472 | 0.0000 | |
| SRP008496 | INPP1 | 3628 | RNAseq | -2.5905 | 0.0000 | |
| SRP064894 | INPP1 | 3628 | RNAseq | -1.4470 | 0.0000 | |
| SRP133303 | INPP1 | 3628 | RNAseq | -1.2561 | 0.0000 | |
| SRP159526 | INPP1 | 3628 | RNAseq | -1.7890 | 0.0000 | |
| SRP193095 | INPP1 | 3628 | RNAseq | -1.7216 | 0.0000 | |
| SRP219564 | INPP1 | 3628 | RNAseq | -1.0719 | 0.0082 | |
| TCGA | INPP1 | 3628 | RNAseq | -0.0473 | 0.6128 |
Upregulated datasets: 0; Downregulated datasets: 14.
Survival by INPP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of INPP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | INPP1 | 3628 | 8 | 2 | 20 | |
| GSE20123 | INPP1 | 3628 | 8 | 2 | 20 | |
| GSE43470 | INPP1 | 3628 | 3 | 1 | 39 | |
| GSE46452 | INPP1 | 3628 | 1 | 4 | 54 | |
| GSE47630 | INPP1 | 3628 | 4 | 5 | 31 | |
| GSE54993 | INPP1 | 3628 | 0 | 5 | 65 | |
| GSE54994 | INPP1 | 3628 | 12 | 6 | 35 | |
| GSE60625 | INPP1 | 3628 | 0 | 3 | 8 | |
| GSE74703 | INPP1 | 3628 | 2 | 1 | 33 | |
| GSE74704 | INPP1 | 3628 | 3 | 2 | 15 | |
| TCGA | INPP1 | 3628 | 23 | 7 | 66 |
Total number of gains: 64; Total number of losses: 38; Total Number of normals: 386.
Somatic mutations of INPP1:
Generating mutation plots.
Highly correlated genes for INPP1:
Showing top 20/1701 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| INPP1 | HDHD2 | 0.808074 | 4 | 0 | 4 |
| INPP1 | CCNYL1 | 0.80005 | 5 | 0 | 5 |
| INPP1 | PITHD1 | 0.772981 | 6 | 0 | 6 |
| INPP1 | FCHO2 | 0.765221 | 7 | 0 | 7 |
| INPP1 | SPAG17 | 0.763513 | 4 | 0 | 4 |
| INPP1 | PLEKHA7 | 0.760602 | 7 | 0 | 7 |
| INPP1 | ACAA1 | 0.759453 | 9 | 0 | 9 |
| INPP1 | TP53I3 | 0.753826 | 11 | 0 | 11 |
| INPP1 | PRKAG1 | 0.753572 | 3 | 0 | 3 |
| INPP1 | ZNF626 | 0.751238 | 4 | 0 | 4 |
| INPP1 | STXBP5 | 0.750609 | 7 | 0 | 7 |
| INPP1 | SFTA2 | 0.74924 | 4 | 0 | 4 |
| INPP1 | FBXO8 | 0.745793 | 6 | 0 | 6 |
| INPP1 | EIF4E3 | 0.744398 | 6 | 0 | 6 |
| INPP1 | FAM174A | 0.742901 | 7 | 0 | 7 |
| INPP1 | C2CD2 | 0.736985 | 3 | 0 | 3 |
| INPP1 | LYSMD3 | 0.736553 | 4 | 0 | 4 |
| INPP1 | SLC16A6 | 0.734767 | 11 | 0 | 11 |
| INPP1 | CYSRT1 | 0.732771 | 6 | 0 | 6 |
| INPP1 | TRIM6 | 0.729484 | 9 | 0 | 8 |
For details and further investigation, click here
