| Full name: N-6 adenine-specific DNA methyltransferase 1 | Alias Symbol: PRED28|N6AMT|MTQ2 | ||
| Type: protein-coding gene | Cytoband: 21q21.3 | ||
| Entrez ID: 29104 | HGNC ID: HGNC:16021 | Ensembl Gene: ENSG00000156239 | OMIM ID: 614553 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of N6AMT1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | N6AMT1 | 29104 | 220311_at | -0.3511 | 0.4730 | |
| GSE20347 | N6AMT1 | 29104 | 220311_at | -0.0420 | 0.7250 | |
| GSE23400 | N6AMT1 | 29104 | 220311_at | -0.0320 | 0.3482 | |
| GSE26886 | N6AMT1 | 29104 | 220311_at | -0.4424 | 0.0182 | |
| GSE29001 | N6AMT1 | 29104 | 220311_at | -0.2358 | 0.2695 | |
| GSE38129 | N6AMT1 | 29104 | 220311_at | -0.2281 | 0.0929 | |
| GSE45670 | N6AMT1 | 29104 | 220311_at | -0.0188 | 0.9334 | |
| GSE53622 | N6AMT1 | 29104 | 37265 | 0.1430 | 0.3347 | |
| GSE53624 | N6AMT1 | 29104 | 37265 | -0.0036 | 0.9696 | |
| GSE63941 | N6AMT1 | 29104 | 220311_at | -0.4628 | 0.4823 | |
| GSE77861 | N6AMT1 | 29104 | 220311_at | -0.2995 | 0.1019 | |
| GSE97050 | N6AMT1 | 29104 | A_33_P3252236 | -0.2320 | 0.2650 | |
| SRP007169 | N6AMT1 | 29104 | RNAseq | 1.1992 | 0.0607 | |
| SRP008496 | N6AMT1 | 29104 | RNAseq | 1.1889 | 0.0440 | |
| SRP064894 | N6AMT1 | 29104 | RNAseq | -0.1756 | 0.3261 | |
| SRP133303 | N6AMT1 | 29104 | RNAseq | -0.2351 | 0.1615 | |
| SRP159526 | N6AMT1 | 29104 | RNAseq | -0.3703 | 0.1799 | |
| SRP193095 | N6AMT1 | 29104 | RNAseq | -0.4082 | 0.0000 | |
| SRP219564 | N6AMT1 | 29104 | RNAseq | -0.7305 | 0.0150 | |
| TCGA | N6AMT1 | 29104 | RNAseq | -0.3999 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by N6AMT1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of N6AMT1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | N6AMT1 | 29104 | 2 | 10 | 18 | |
| GSE20123 | N6AMT1 | 29104 | 2 | 10 | 18 | |
| GSE43470 | N6AMT1 | 29104 | 1 | 8 | 34 | |
| GSE46452 | N6AMT1 | 29104 | 1 | 21 | 37 | |
| GSE47630 | N6AMT1 | 29104 | 6 | 17 | 17 | |
| GSE54993 | N6AMT1 | 29104 | 9 | 1 | 60 | |
| GSE54994 | N6AMT1 | 29104 | 1 | 9 | 43 | |
| GSE60625 | N6AMT1 | 29104 | 0 | 0 | 11 | |
| GSE74703 | N6AMT1 | 29104 | 1 | 6 | 29 | |
| GSE74704 | N6AMT1 | 29104 | 2 | 6 | 12 | |
| TCGA | N6AMT1 | 29104 | 9 | 37 | 50 |
Total number of gains: 34; Total number of losses: 125; Total Number of normals: 329.
Somatic mutations of N6AMT1:
Generating mutation plots.
Highly correlated genes for N6AMT1:
Showing top 20/326 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| N6AMT1 | SYNC | 0.791068 | 3 | 0 | 3 |
| N6AMT1 | ADARB1 | 0.758654 | 3 | 0 | 3 |
| N6AMT1 | NACC2 | 0.749186 | 3 | 0 | 3 |
| N6AMT1 | BCAS2 | 0.747713 | 3 | 0 | 3 |
| N6AMT1 | SPEG | 0.744308 | 3 | 0 | 3 |
| N6AMT1 | GRIA4 | 0.739515 | 3 | 0 | 3 |
| N6AMT1 | DEXI | 0.73277 | 3 | 0 | 3 |
| N6AMT1 | INPP5A | 0.73067 | 3 | 0 | 3 |
| N6AMT1 | GLYR1 | 0.727825 | 3 | 0 | 3 |
| N6AMT1 | FAM83D | 0.726924 | 4 | 0 | 3 |
| N6AMT1 | TMEM126A | 0.716748 | 3 | 0 | 3 |
| N6AMT1 | MEOX2 | 0.714994 | 3 | 0 | 3 |
| N6AMT1 | NSMCE1 | 0.712248 | 3 | 0 | 3 |
| N6AMT1 | RASL12 | 0.710521 | 3 | 0 | 3 |
| N6AMT1 | ALG11 | 0.700944 | 3 | 0 | 3 |
| N6AMT1 | SPOP | 0.699577 | 3 | 0 | 3 |
| N6AMT1 | PRKAG2 | 0.696572 | 4 | 0 | 4 |
| N6AMT1 | SRP14 | 0.695821 | 3 | 0 | 3 |
| N6AMT1 | SGCA | 0.695756 | 3 | 0 | 3 |
| N6AMT1 | GNAQ | 0.691891 | 3 | 0 | 3 |
For details and further investigation, click here
