| Full name: ERCC excision repair 4, endonuclease catalytic subunit | Alias Symbol: RAD1|FANCQ | ||
| Type: protein-coding gene | Cytoband: 16p13.12 | ||
| Entrez ID: 2072 | HGNC ID: HGNC:3436 | Ensembl Gene: ENSG00000175595 | OMIM ID: 133520 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of ERCC4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ERCC4 | 2072 | 210158_at | 0.2725 | 0.4702 | |
| GSE20347 | ERCC4 | 2072 | 210158_at | 0.0144 | 0.8969 | |
| GSE23400 | ERCC4 | 2072 | 210158_at | -0.0145 | 0.7267 | |
| GSE26886 | ERCC4 | 2072 | 235215_at | -0.5291 | 0.0821 | |
| GSE29001 | ERCC4 | 2072 | 210158_at | -0.0233 | 0.8973 | |
| GSE38129 | ERCC4 | 2072 | 210158_at | -0.1110 | 0.2776 | |
| GSE45670 | ERCC4 | 2072 | 235215_at | 0.6644 | 0.0012 | |
| GSE53622 | ERCC4 | 2072 | 63415 | 0.5854 | 0.0000 | |
| GSE53624 | ERCC4 | 2072 | 63415 | 0.7210 | 0.0000 | |
| GSE63941 | ERCC4 | 2072 | 235215_at | -0.6260 | 0.1630 | |
| GSE77861 | ERCC4 | 2072 | 210158_at | -0.1250 | 0.3190 | |
| GSE97050 | ERCC4 | 2072 | A_33_P3243364 | 0.3533 | 0.2824 | |
| SRP007169 | ERCC4 | 2072 | RNAseq | 0.8876 | 0.0365 | |
| SRP008496 | ERCC4 | 2072 | RNAseq | 1.2909 | 0.0000 | |
| SRP064894 | ERCC4 | 2072 | RNAseq | 0.3624 | 0.0667 | |
| SRP133303 | ERCC4 | 2072 | RNAseq | 0.5900 | 0.0000 | |
| SRP159526 | ERCC4 | 2072 | RNAseq | 0.3256 | 0.2874 | |
| SRP193095 | ERCC4 | 2072 | RNAseq | 0.3370 | 0.0000 | |
| SRP219564 | ERCC4 | 2072 | RNAseq | 0.1916 | 0.5092 | |
| TCGA | ERCC4 | 2072 | RNAseq | -0.0755 | 0.2067 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by ERCC4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ERCC4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ERCC4 | 2072 | 5 | 4 | 21 | |
| GSE20123 | ERCC4 | 2072 | 5 | 3 | 22 | |
| GSE43470 | ERCC4 | 2072 | 3 | 2 | 38 | |
| GSE46452 | ERCC4 | 2072 | 38 | 1 | 20 | |
| GSE47630 | ERCC4 | 2072 | 14 | 6 | 20 | |
| GSE54993 | ERCC4 | 2072 | 3 | 5 | 62 | |
| GSE54994 | ERCC4 | 2072 | 5 | 9 | 39 | |
| GSE60625 | ERCC4 | 2072 | 4 | 0 | 7 | |
| GSE74703 | ERCC4 | 2072 | 3 | 2 | 31 | |
| GSE74704 | ERCC4 | 2072 | 2 | 1 | 17 | |
| TCGA | ERCC4 | 2072 | 20 | 11 | 65 |
Total number of gains: 102; Total number of losses: 44; Total Number of normals: 342.
Somatic mutations of ERCC4:
Generating mutation plots.
Highly correlated genes for ERCC4:
Showing top 20/417 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ERCC4 | SMOX | 0.7794 | 3 | 0 | 3 |
| ERCC4 | PRLR | 0.773446 | 4 | 0 | 4 |
| ERCC4 | REL | 0.7563 | 3 | 0 | 3 |
| ERCC4 | CYSLTR2 | 0.74071 | 5 | 0 | 5 |
| ERCC4 | CELA3A | 0.73535 | 3 | 0 | 3 |
| ERCC4 | PWWP2A | 0.723106 | 3 | 0 | 3 |
| ERCC4 | SRFBP1 | 0.721152 | 3 | 0 | 3 |
| ERCC4 | CDYL2 | 0.717291 | 4 | 0 | 3 |
| ERCC4 | NAA60 | 0.711428 | 3 | 0 | 3 |
| ERCC4 | HIBADH | 0.705747 | 3 | 0 | 3 |
| ERCC4 | KIR2DS2 | 0.704118 | 5 | 0 | 5 |
| ERCC4 | DSE | 0.703302 | 3 | 0 | 3 |
| ERCC4 | TAOK1 | 0.702765 | 5 | 0 | 5 |
| ERCC4 | UBLCP1 | 0.701902 | 3 | 0 | 3 |
| ERCC4 | ADCY7 | 0.70071 | 3 | 0 | 3 |
| ERCC4 | RNASEL | 0.700288 | 4 | 0 | 4 |
| ERCC4 | CARHSP1 | 0.696118 | 3 | 0 | 3 |
| ERCC4 | GPA33 | 0.691038 | 5 | 0 | 5 |
| ERCC4 | MED24 | 0.688539 | 5 | 0 | 5 |
| ERCC4 | GDF5 | 0.688116 | 6 | 0 | 5 |
For details and further investigation, click here
