| Full name: small proline rich protein 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1q21.3 | ||
| Entrez ID: 6707 | HGNC ID: HGNC:11268 | Ensembl Gene: ENSG00000163209 | OMIM ID: 182271 |
| Drug and gene relationship at DGIdb | |||
Expression of SPRR3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPRR3 | 6707 | 218990_s_at | -2.5622 | 0.1823 | |
| GSE20347 | SPRR3 | 6707 | 218990_s_at | -3.3295 | 0.0004 | |
| GSE23400 | SPRR3 | 6707 | 218990_s_at | -2.2223 | 0.0000 | |
| GSE26886 | SPRR3 | 6707 | 232082_x_at | -6.4544 | 0.0000 | |
| GSE29001 | SPRR3 | 6707 | 218990_s_at | -5.3880 | 0.0001 | |
| GSE38129 | SPRR3 | 6707 | 218990_s_at | -2.1262 | 0.0156 | |
| GSE45670 | SPRR3 | 6707 | 218990_s_at | -0.5596 | 0.0310 | |
| GSE53622 | SPRR3 | 6707 | 92203 | -3.5093 | 0.0000 | |
| GSE53624 | SPRR3 | 6707 | 92203 | -4.0807 | 0.0000 | |
| GSE63941 | SPRR3 | 6707 | 218990_s_at | 1.4302 | 0.3445 | |
| GSE77861 | SPRR3 | 6707 | 232082_x_at | -0.8005 | 0.1450 | |
| GSE97050 | SPRR3 | 6707 | A_23_P62709 | -2.5302 | 0.0614 | |
| SRP007169 | SPRR3 | 6707 | RNAseq | -7.0861 | 0.0000 | |
| SRP008496 | SPRR3 | 6707 | RNAseq | -6.6659 | 0.0000 | |
| SRP064894 | SPRR3 | 6707 | RNAseq | -5.6220 | 0.0000 | |
| SRP133303 | SPRR3 | 6707 | RNAseq | -6.3670 | 0.0000 | |
| SRP159526 | SPRR3 | 6707 | RNAseq | -6.1422 | 0.0000 | |
| SRP219564 | SPRR3 | 6707 | RNAseq | -5.4090 | 0.0001 | |
| TCGA | SPRR3 | 6707 | RNAseq | 0.2489 | 0.6196 |
Upregulated datasets: 0; Downregulated datasets: 13.
Survival by SPRR3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPRR3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPRR3 | 6707 | 15 | 0 | 15 | |
| GSE20123 | SPRR3 | 6707 | 15 | 0 | 15 | |
| GSE43470 | SPRR3 | 6707 | 6 | 2 | 35 | |
| GSE46452 | SPRR3 | 6707 | 3 | 1 | 55 | |
| GSE47630 | SPRR3 | 6707 | 15 | 0 | 25 | |
| GSE54993 | SPRR3 | 6707 | 0 | 4 | 66 | |
| GSE54994 | SPRR3 | 6707 | 15 | 0 | 38 | |
| GSE60625 | SPRR3 | 6707 | 0 | 0 | 11 | |
| GSE74703 | SPRR3 | 6707 | 6 | 1 | 29 | |
| GSE74704 | SPRR3 | 6707 | 7 | 0 | 13 | |
| TCGA | SPRR3 | 6707 | 39 | 2 | 55 |
Total number of gains: 121; Total number of losses: 10; Total Number of normals: 357.
Somatic mutations of SPRR3:
Generating mutation plots.
Highly correlated genes for SPRR3:
Showing top 20/1336 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPRR3 | CYSRT1 | 0.906806 | 6 | 0 | 6 |
| SPRR3 | KRT13 | 0.901338 | 12 | 0 | 12 |
| SPRR3 | VSIG10L | 0.876513 | 7 | 0 | 7 |
| SPRR3 | CRNN | 0.870767 | 12 | 0 | 12 |
| SPRR3 | TMPRSS11E | 0.869645 | 11 | 0 | 11 |
| SPRR3 | TMPRSS11B | 0.868861 | 8 | 0 | 8 |
| SPRR3 | TGM3 | 0.865416 | 13 | 0 | 13 |
| SPRR3 | SCEL | 0.862824 | 12 | 0 | 12 |
| SPRR3 | MAL | 0.851707 | 12 | 0 | 12 |
| SPRR3 | CLCA4 | 0.84995 | 12 | 0 | 12 |
| SPRR3 | NCCRP1 | 0.844491 | 4 | 0 | 4 |
| SPRR3 | LYNX1 | 0.844142 | 8 | 0 | 8 |
| SPRR3 | KRT4 | 0.842677 | 12 | 0 | 12 |
| SPRR3 | MUC15 | 0.839313 | 7 | 0 | 7 |
| SPRR3 | SPRR1A | 0.834346 | 13 | 0 | 13 |
| SPRR3 | PRSS27 | 0.833741 | 8 | 0 | 8 |
| SPRR3 | SPINK5 | 0.832753 | 13 | 0 | 13 |
| SPRR3 | A2ML1 | 0.829684 | 8 | 0 | 8 |
| SPRR3 | CNFN | 0.829628 | 8 | 0 | 8 |
| SPRR3 | CAPN14 | 0.825438 | 7 | 0 | 7 |
For details and further investigation, click here
