| Full name: myosin heavy chain 11 | Alias Symbol: SMMHC|SMHC | ||
| Type: protein-coding gene | Cytoband: 16p13.11 | ||
| Entrez ID: 4629 | HGNC ID: HGNC:7569 | Ensembl Gene: ENSG00000133392 | OMIM ID: 160745 |
| Drug and gene relationship at DGIdb | |||
MYH11 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04270 | Vascular smooth muscle contraction | |
| hsa04530 | Tight junction |
Expression of MYH11:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MYH11 | 4629 | 201497_x_at | -2.4214 | 0.1633 | |
| GSE20347 | MYH11 | 4629 | 201497_x_at | -1.5800 | 0.0073 | |
| GSE23400 | MYH11 | 4629 | 201497_x_at | -1.2884 | 0.0000 | |
| GSE26886 | MYH11 | 4629 | 201497_x_at | 2.2682 | 0.0116 | |
| GSE29001 | MYH11 | 4629 | 201497_x_at | -1.4720 | 0.0325 | |
| GSE38129 | MYH11 | 4629 | 201497_x_at | -1.6997 | 0.0046 | |
| GSE45670 | MYH11 | 4629 | 201497_x_at | -4.2129 | 0.0000 | |
| GSE53622 | MYH11 | 4629 | 51222 | -2.7164 | 0.0000 | |
| GSE53624 | MYH11 | 4629 | 51222 | -2.6564 | 0.0000 | |
| GSE63941 | MYH11 | 4629 | 207961_x_at | 0.0398 | 0.8564 | |
| GSE77861 | MYH11 | 4629 | 207961_x_at | 0.5794 | 0.2129 | |
| GSE97050 | MYH11 | 4629 | A_23_P206920 | -2.6744 | 0.0555 | |
| SRP007169 | MYH11 | 4629 | RNAseq | 4.2183 | 0.0000 | |
| SRP008496 | MYH11 | 4629 | RNAseq | 5.4509 | 0.0000 | |
| SRP064894 | MYH11 | 4629 | RNAseq | -1.0974 | 0.0487 | |
| SRP133303 | MYH11 | 4629 | RNAseq | -3.4876 | 0.0000 | |
| SRP159526 | MYH11 | 4629 | RNAseq | -1.9616 | 0.0136 | |
| SRP193095 | MYH11 | 4629 | RNAseq | -0.6044 | 0.3267 | |
| SRP219564 | MYH11 | 4629 | RNAseq | -1.3425 | 0.3357 | |
| TCGA | MYH11 | 4629 | RNAseq | -0.7778 | 0.0005 |
Upregulated datasets: 3; Downregulated datasets: 10.
Survival by MYH11 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MYH11:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MYH11 | 4629 | 5 | 5 | 20 | |
| GSE20123 | MYH11 | 4629 | 5 | 4 | 21 | |
| GSE43470 | MYH11 | 4629 | 3 | 3 | 37 | |
| GSE46452 | MYH11 | 4629 | 38 | 1 | 20 | |
| GSE47630 | MYH11 | 4629 | 11 | 6 | 23 | |
| GSE54993 | MYH11 | 4629 | 3 | 5 | 62 | |
| GSE54994 | MYH11 | 4629 | 4 | 10 | 39 | |
| GSE60625 | MYH11 | 4629 | 4 | 1 | 6 | |
| GSE74703 | MYH11 | 4629 | 3 | 2 | 31 | |
| GSE74704 | MYH11 | 4629 | 2 | 1 | 17 | |
| TCGA | MYH11 | 4629 | 20 | 12 | 64 |
Total number of gains: 98; Total number of losses: 50; Total Number of normals: 340.
Somatic mutations of MYH11:
Generating mutation plots.
Highly correlated genes for MYH11:
Showing top 20/734 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MYH11 | ACTG2 | 0.887235 | 12 | 0 | 12 |
| MYH11 | CNN1 | 0.864068 | 10 | 0 | 10 |
| MYH11 | LMOD1 | 0.863733 | 12 | 0 | 12 |
| MYH11 | PLN | 0.846813 | 12 | 0 | 12 |
| MYH11 | DES | 0.828302 | 12 | 0 | 12 |
| MYH11 | PRUNE2 | 0.824894 | 12 | 0 | 12 |
| MYH11 | SYNM | 0.815174 | 12 | 0 | 12 |
| MYH11 | MYOCD | 0.812505 | 6 | 0 | 6 |
| MYH11 | AOC3 | 0.811121 | 12 | 0 | 12 |
| MYH11 | SYNPO2 | 0.808345 | 8 | 0 | 7 |
| MYH11 | ACTA2 | 0.807151 | 12 | 0 | 12 |
| MYH11 | CHRDL1 | 0.803898 | 9 | 0 | 9 |
| MYH11 | PCP4 | 0.800646 | 11 | 0 | 11 |
| MYH11 | MIR100HG | 0.783176 | 5 | 0 | 5 |
| MYH11 | SMOC2 | 0.78011 | 8 | 0 | 8 |
| MYH11 | TAGLN | 0.776688 | 11 | 0 | 11 |
| MYH11 | ANGPTL1 | 0.776629 | 6 | 0 | 6 |
| MYH11 | ACTBL2 | 0.776501 | 3 | 0 | 3 |
| MYH11 | FHL1 | 0.774678 | 12 | 0 | 12 |
| MYH11 | MRVI1 | 0.771796 | 7 | 0 | 7 |
For details and further investigation, click here
