SMC3

 

Full name: structural maintenance of chromosomes 3 Alias Symbol: HCAP|BAM|SMC3L1|bamacan
Type: protein-coding gene Cytoband: 10q25.2
Entrez ID: 9126 HGNC ID: HGNC:2468 Ensembl Gene: ENSG00000108055 OMIM ID: 606062
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

SMC3 involved pathways:

KEGG pathway Description View
hsa04110Cell cycle

 

Expression of SMC3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SMC3 9126 209259_s_at 0.2880 0.5096
GSE20347 SMC3 9126 209259_s_at 0.2823 0.1456
GSE23400 SMC3 9126 209259_s_at 0.6489 0.0000
GSE26886 SMC3 9126 209259_s_at 0.2699 0.4281
GSE29001 SMC3 9126 209259_s_at 0.5717 0.0928
GSE38129 SMC3 9126 209259_s_at 0.4412 0.0010
GSE45670 SMC3 9126 209259_s_at 0.1353 0.3451
GSE53622 SMC3 9126 4810 0.1784 0.0014
GSE53624 SMC3 9126 4810 0.2765 0.0002
GSE63941 SMC3 9126 209259_s_at 0.1877 0.6857
GSE77861 SMC3 9126 209259_s_at 0.4701 0.1366
GSE97050 SMC3 9126 A_23_P138631 0.3126 0.3194
SRP007169 SMC3 9126 RNAseq 0.5730 0.0864
SRP008496 SMC3 9126 RNAseq 0.9916 0.0001
SRP064894 SMC3 9126 RNAseq -0.0031 0.9908
SRP133303 SMC3 9126 RNAseq 0.3557 0.0152
SRP159526 SMC3 9126 RNAseq 0.2033 0.5081
SRP193095 SMC3 9126 RNAseq 0.2387 0.0067
SRP219564 SMC3 9126 RNAseq 0.1318 0.7007
TCGA SMC3 9126 RNAseq 0.1188 0.0099

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by SMC3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SMC3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SMC3 9126 1 9 20
GSE20123 SMC3 9126 1 8 21
GSE43470 SMC3 9126 0 7 36
GSE46452 SMC3 9126 0 11 48
GSE47630 SMC3 9126 2 14 24
GSE54993 SMC3 9126 8 0 62
GSE54994 SMC3 9126 1 10 42
GSE60625 SMC3 9126 0 0 11
GSE74703 SMC3 9126 0 5 31
GSE74704 SMC3 9126 1 4 15
TCGA SMC3 9126 4 28 64

Total number of gains: 18; Total number of losses: 96; Total Number of normals: 374.  

 

Somatic mutations of SMC3:

 

Generating mutation plots.

 

Highly correlated genes for SMC3:

 

Showing top 20/1404 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SMC3ACBD50.812912303
SMC3CNOT100.808934303
SMC3PDIK1L0.793566303
SMC3RAD180.781271303
SMC3PSMC60.762161303
SMC3CCDC150.757728303
SMC3LRRC340.753798303
SMC3FAM160B10.753328303
SMC3TM2D20.749601404
SMC3POM1210.745375303
SMC3WDR920.733482303
SMC3HNRNPR0.71501211010
SMC3FAM118B0.712125303
SMC3FBXW90.711746303
SMC3ZFX0.709968303
SMC3TMEM1810.708533403
SMC3ATP6V1H0.706499303
SMC3ELOF10.702621403
SMC3PARG0.702087606
SMC3DNPEP0.701732403

For details and further investigation, click here