| Full name: psoriasis susceptibility 1 candidate 1 | Alias Symbol: SEEK1 | ||
| Type: protein-coding gene | Cytoband: 6p21.33 | ||
| Entrez ID: 170679 | HGNC ID: HGNC:17202 | Ensembl Gene: ENSG00000204540 | OMIM ID: 613525 |
| Drug and gene relationship at DGIdb | |||
Expression of PSORS1C1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PSORS1C1 | 170679 | 220362_at | 0.1183 | 0.8088 | |
| GSE20347 | PSORS1C1 | 170679 | 220362_at | -0.0461 | 0.5876 | |
| GSE23400 | PSORS1C1 | 170679 | 220362_at | -0.0315 | 0.4064 | |
| GSE26886 | PSORS1C1 | 170679 | 220362_at | 0.2027 | 0.1982 | |
| GSE29001 | PSORS1C1 | 170679 | 220362_at | -0.1354 | 0.4646 | |
| GSE38129 | PSORS1C1 | 170679 | 220362_at | -0.0700 | 0.2257 | |
| GSE45670 | PSORS1C1 | 170679 | 220362_at | 0.2534 | 0.1427 | |
| GSE53622 | PSORS1C1 | 170679 | 56526 | 0.1968 | 0.0600 | |
| GSE53624 | PSORS1C1 | 170679 | 56526 | 0.0193 | 0.8587 | |
| GSE63941 | PSORS1C1 | 170679 | 220362_at | 0.2193 | 0.4004 | |
| GSE77861 | PSORS1C1 | 170679 | 220362_at | -0.0292 | 0.8373 | |
| SRP133303 | PSORS1C1 | 170679 | RNAseq | 0.8721 | 0.0142 | |
| SRP159526 | PSORS1C1 | 170679 | RNAseq | 0.6092 | 0.2995 | |
| SRP219564 | PSORS1C1 | 170679 | RNAseq | 1.1297 | 0.1652 | |
| TCGA | PSORS1C1 | 170679 | RNAseq | 0.6938 | 0.0595 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PSORS1C1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PSORS1C1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PSORS1C1 | 170679 | 5 | 1 | 24 | |
| GSE20123 | PSORS1C1 | 170679 | 5 | 1 | 24 | |
| GSE43470 | PSORS1C1 | 170679 | 5 | 1 | 37 | |
| GSE46452 | PSORS1C1 | 170679 | 1 | 10 | 48 | |
| GSE47630 | PSORS1C1 | 170679 | 7 | 3 | 30 | |
| GSE54993 | PSORS1C1 | 170679 | 2 | 1 | 67 | |
| GSE54994 | PSORS1C1 | 170679 | 11 | 4 | 38 | |
| GSE60625 | PSORS1C1 | 170679 | 0 | 1 | 10 | |
| GSE74703 | PSORS1C1 | 170679 | 5 | 0 | 31 | |
| GSE74704 | PSORS1C1 | 170679 | 2 | 0 | 18 | |
| TCGA | PSORS1C1 | 170679 | 17 | 16 | 63 |
Total number of gains: 60; Total number of losses: 38; Total Number of normals: 390.
Somatic mutations of PSORS1C1:
Generating mutation plots.
Highly correlated genes for PSORS1C1:
Showing top 20/27 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PSORS1C1 | BTBD18 | 0.663158 | 3 | 0 | 3 |
| PSORS1C1 | PKLR | 0.650446 | 4 | 0 | 3 |
| PSORS1C1 | FGF22 | 0.60884 | 3 | 0 | 3 |
| PSORS1C1 | POU5F1B | 0.608655 | 4 | 0 | 3 |
| PSORS1C1 | LPAR3 | 0.591067 | 4 | 0 | 3 |
| PSORS1C1 | KLRC3 | 0.582018 | 3 | 0 | 3 |
| PSORS1C1 | EFNB1 | 0.571246 | 3 | 0 | 3 |
| PSORS1C1 | KLK5 | 0.566745 | 3 | 0 | 3 |
| PSORS1C1 | GRM4 | 0.566593 | 3 | 0 | 3 |
| PSORS1C1 | HSF1 | 0.557946 | 3 | 0 | 3 |
| PSORS1C1 | IL12RB2 | 0.554172 | 5 | 0 | 4 |
| PSORS1C1 | SHARPIN | 0.554025 | 4 | 0 | 3 |
| PSORS1C1 | LTB4R2 | 0.55161 | 4 | 0 | 3 |
| PSORS1C1 | ZNF835 | 0.545934 | 4 | 0 | 3 |
| PSORS1C1 | SBNO2 | 0.537951 | 5 | 0 | 3 |
| PSORS1C1 | PLCH2 | 0.531973 | 5 | 0 | 3 |
| PSORS1C1 | CIDEB | 0.529671 | 4 | 0 | 3 |
| PSORS1C1 | PRAM1 | 0.528287 | 3 | 0 | 3 |
| PSORS1C1 | KCP | 0.527327 | 4 | 0 | 3 |
| PSORS1C1 | TNFRSF25 | 0.527314 | 4 | 0 | 3 |
For details and further investigation, click here
