PTMA

 

Full name: prothymosin alpha Alias Symbol: 
Type: protein-coding gene Cytoband: 2q37.1
Entrez ID: 5757 HGNC ID: HGNC:9623 Ensembl Gene: ENSG00000187514 OMIM ID: 188390
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 114/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of PTMA:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PTMA 5757 200773_x_at 0.1219 0.5703
GSE20347 PTMA 5757 200773_x_at 0.2601 0.0027
GSE23400 PTMA 5757 200773_x_at 0.3071 0.0000
GSE26886 PTMA 5757 200773_x_at -0.3184 0.0231
GSE29001 PTMA 5757 200773_x_at 0.2159 0.1713
GSE38129 PTMA 5757 200773_x_at 0.2129 0.0091
GSE45670 PTMA 5757 200773_x_at 0.0399 0.7433
GSE53622 PTMA 5757 118961 0.4834 0.0000
GSE53624 PTMA 5757 118961 0.7193 0.0000
GSE63941 PTMA 5757 200773_x_at 0.2496 0.3773
GSE77861 PTMA 5757 200773_x_at 0.0984 0.3605
GSE97050 PTMA A_21_P0013910 0.8607 0.0635
SRP007169 PTMA 5757 RNAseq 0.6694 0.0923
SRP008496 PTMA 5757 RNAseq 0.8922 0.0014
SRP064894 PTMA 5757 RNAseq 0.2302 0.1255
SRP133303 PTMA 5757 RNAseq 0.4340 0.0024
SRP159526 PTMA 5757 RNAseq 0.4663 0.0771
SRP193095 PTMA 5757 RNAseq -0.0203 0.8733
SRP219564 PTMA 5757 RNAseq 0.2798 0.2863
TCGA PTMA 5757 RNAseq 0.1088 0.0063

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by PTMA expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PTMA:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PTMA 5757 1 12 17
GSE20123 PTMA 5757 1 12 17
GSE43470 PTMA 5757 1 8 34
GSE46452 PTMA 5757 0 5 54
GSE47630 PTMA 5757 4 5 31
GSE54993 PTMA 5757 2 2 66
GSE54994 PTMA 5757 6 10 37
GSE60625 PTMA 5757 0 3 8
GSE74703 PTMA 5757 1 6 29
GSE74704 PTMA 5757 1 5 14
TCGA PTMA 5757 12 27 57

Total number of gains: 29; Total number of losses: 95; Total Number of normals: 364.  

 

Somatic mutations of PTMA:

 

Generating mutation plots.

 

Highly correlated genes for PTMA:

 

Showing top 20/333 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PTMAMIR1244-30.901807909
PTMAC19orf530.655162303
PTMANAT140.640849303
PTMATMEM2050.636386303
PTMABBS50.634299303
PTMAHNRNPR0.630724705
PTMAPDHA10.629278303
PTMARCC20.6263404
PTMASNAP470.620086303
PTMARBBP40.6141951109
PTMABTBD30.613258503
PTMATTYH30.604028403
PTMAPRKDC0.602342707
PTMAARL30.594923404
PTMAHSP90B10.593526605
PTMAHMGB10.5925331008
PTMAPOT10.591527705
PTMAHNRNPA2B10.5907241007
PTMAPCNA0.588892907
PTMACNNM30.587035403

For details and further investigation, click here