HMGB1

 

Full name: high mobility group box 1 Alias Symbol: HMG3|SBP-1|DKFZp686A04236
Type: protein-coding gene Cytoband: 13q12.3
Entrez ID: 3146 HGNC ID: HGNC:4983 Ensembl Gene: ENSG00000189403 OMIM ID: 163905
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of HMGB1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 HMGB1 3146 200680_x_at 0.2984 0.3743
GSE20347 HMGB1 3146 214938_x_at 0.3234 0.0002
GSE23400 HMGB1 3146 214938_x_at 0.2456 0.0001
GSE26886 HMGB1 3146 214938_x_at -0.1499 0.2604
GSE29001 HMGB1 3146 214938_x_at 0.2614 0.0230
GSE38129 HMGB1 3146 214938_x_at 0.3091 0.0000
GSE45670 HMGB1 3146 214938_x_at 0.0650 0.6108
GSE53622 HMGB1 3146 149697 0.1194 0.0255
GSE53624 HMGB1 3146 37468 0.6649 0.0000
GSE63941 HMGB1 3146 200680_x_at 0.4252 0.1232
GSE77861 HMGB1 3146 200680_x_at 0.3827 0.0528
GSE97050 HMGB1 3146 A_24_P169148 0.1391 0.4692
SRP007169 HMGB1 3146 RNAseq -0.0144 0.9693
SRP008496 HMGB1 3146 RNAseq 0.2653 0.2396
SRP064894 HMGB1 3146 RNAseq 0.3259 0.0330
SRP133303 HMGB1 3146 RNAseq 0.3052 0.1418
SRP159526 HMGB1 3146 RNAseq 0.2399 0.4188
SRP193095 HMGB1 3146 RNAseq -0.1128 0.4129
SRP219564 HMGB1 3146 RNAseq -0.1485 0.6768
TCGA HMGB1 3146 RNAseq 0.0917 0.0303

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by HMGB1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of HMGB1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 HMGB1 3146 1 13 16
GSE20123 HMGB1 3146 1 12 17
GSE43470 HMGB1 3146 2 12 29
GSE46452 HMGB1 3146 0 33 26
GSE47630 HMGB1 3146 2 27 11
GSE54993 HMGB1 3146 12 2 56
GSE54994 HMGB1 3146 2 14 37
GSE60625 HMGB1 3146 0 3 8
GSE74703 HMGB1 3146 2 9 25
GSE74704 HMGB1 3146 0 10 10
TCGA HMGB1 3146 8 37 51

Total number of gains: 30; Total number of losses: 172; Total Number of normals: 286.  

 

Somatic mutations of HMGB1:

 

Generating mutation plots.

 

Highly correlated genes for HMGB1:

 

Showing top 20/1260 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
HMGB1MRPS60.794087404
HMGB1LRRC580.775268303
HMGB1TADA10.767605303
HMGB1LEMD20.764725303
HMGB1UBQLN40.74217303
HMGB1PRR120.74173303
HMGB1KRTCAP20.737644303
HMGB1ZMYND190.733249303
HMGB1DEXI0.73251303
HMGB1LYAR0.731615303
HMGB1ZNF5670.730327303
HMGB1SF3B40.729696505
HMGB1TIGD10.729586403
HMGB1EIF5B0.728785303
HMGB1NOM10.728768404
HMGB1SMCR80.721536303
HMGB1SLC39A10.720801404
HMGB1YWHAG0.714403404
HMGB1TRAPPC6B0.710404303
HMGB1TRPM40.709105303

For details and further investigation, click here