POT1

 

Full name: protection of telomeres 1 Alias Symbol: hPot1|DKFZp586D211
Type: protein-coding gene Cytoband: 7q31.33
Entrez ID: 25913 HGNC ID: HGNC:17284 Ensembl Gene: ENSG00000128513 OMIM ID: 606478
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of POT1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 POT1 25913 204354_at 0.3210 0.5754
GSE20347 POT1 25913 204354_at 0.8918 0.0000
GSE23400 POT1 25913 204354_at 0.7779 0.0000
GSE26886 POT1 25913 204354_at 0.4638 0.0369
GSE29001 POT1 25913 204354_at 1.1250 0.0003
GSE38129 POT1 25913 204354_at 0.8589 0.0000
GSE45670 POT1 25913 204354_at 0.3161 0.0774
GSE53622 POT1 25913 42581 0.5966 0.0000
GSE53624 POT1 25913 42581 0.7537 0.0000
GSE63941 POT1 25913 204354_at 0.2907 0.5798
GSE77861 POT1 25913 204354_at 0.1121 0.8041
GSE97050 POT1 25913 A_33_P3882624 0.2634 0.5091
SRP007169 POT1 25913 RNAseq 0.8000 0.0608
SRP008496 POT1 25913 RNAseq 1.0785 0.0001
SRP064894 POT1 25913 RNAseq 0.7112 0.0000
SRP133303 POT1 25913 RNAseq 0.6723 0.0004
SRP159526 POT1 25913 RNAseq 0.0110 0.9652
SRP193095 POT1 25913 RNAseq 0.3356 0.0134
SRP219564 POT1 25913 RNAseq -0.1445 0.5182
TCGA POT1 25913 RNAseq 0.0762 0.2059

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by POT1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of POT1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 POT1 25913 6 2 22
GSE20123 POT1 25913 7 2 21
GSE43470 POT1 25913 2 4 37
GSE46452 POT1 25913 7 2 50
GSE47630 POT1 25913 7 4 29
GSE54993 POT1 25913 3 5 62
GSE54994 POT1 25913 9 7 37
GSE60625 POT1 25913 0 0 11
GSE74703 POT1 25913 2 4 30
GSE74704 POT1 25913 5 2 13
TCGA POT1 25913 27 22 47

Total number of gains: 75; Total number of losses: 54; Total Number of normals: 359.  

 

Somatic mutations of POT1:

 

Generating mutation plots.

 

Highly correlated genes for POT1:

 

Showing top 20/935 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
POT1ITPRIPL20.722698303
POT1CBX30.679421908
POT1PCGF50.668444303
POT1RFC30.6560971009
POT1DBF40.652557908
POT1LRRC340.652159404
POT1C10orf550.651529303
POT1XPO10.65119911010
POT1CENPL0.650786606
POT1ANKRD160.649866303
POT1G2E30.649029404
POT1RBM280.64827707
POT1LSM80.647703909
POT1E2F60.6414371009
POT1JOSD10.640987605
POT1MIR1244-30.635736505
POT1HSPA130.635481605
POT1PBK0.635373806
POT1MEST0.6325061008
POT1NUP620.6298831008

For details and further investigation, click here