PRKDC

 

Full name: protein kinase, DNA-activated, catalytic subunit Alias Symbol: DNPK1|p350|DNAPK|XRCC7|DNA-PKcs|DNAPKc|DNA-PKC|p460
Type: protein-coding gene Cytoband: 8q11.21
Entrez ID: 5591 HGNC ID: HGNC:9413 Ensembl Gene: ENSG00000253729 OMIM ID: 600899
Drug and gene relationship at DGIdb

 

PRKDC involved pathways:

KEGG pathway Description View
hsa04110Cell cycle

 

Expression of PRKDC:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PRKDC 5591 208694_at 1.0798 0.0380
GSE20347 PRKDC 5591 208694_at 0.9710 0.0000
GSE23400 PRKDC 5591 208694_at 1.2535 0.0000
GSE26886 PRKDC 5591 208694_at 0.7515 0.0018
GSE29001 PRKDC 5591 208694_at 0.9204 0.0396
GSE38129 PRKDC 5591 208694_at 1.0877 0.0000
GSE45670 PRKDC 5591 208694_at 0.8181 0.0000
GSE53622 PRKDC 5591 23815 0.8928 0.0000
GSE53624 PRKDC 5591 20777 1.1183 0.0000
GSE63941 PRKDC 5591 208694_at 0.0634 0.8848
GSE77861 PRKDC 5591 208694_at 0.9089 0.0199
GSE97050 PRKDC 5591 A_23_P9603 0.7572 0.1166
SRP007169 PRKDC 5591 RNAseq 2.2941 0.0000
SRP008496 PRKDC 5591 RNAseq 2.0983 0.0000
SRP064894 PRKDC 5591 RNAseq 1.4105 0.0000
SRP133303 PRKDC 5591 RNAseq 0.7498 0.0000
SRP159526 PRKDC 5591 RNAseq 0.8270 0.0081
SRP193095 PRKDC 5591 RNAseq 0.8506 0.0000
SRP219564 PRKDC 5591 RNAseq 0.9853 0.0028
TCGA PRKDC 5591 RNAseq 0.2594 0.0000

Upregulated datasets: 7; Downregulated datasets: 0.  

 

Survival by PRKDC expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PRKDC:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PRKDC 5591 16 1 13
GSE20123 PRKDC 5591 16 1 13
GSE43470 PRKDC 5591 14 3 26
GSE46452 PRKDC 5591 21 3 35
GSE47630 PRKDC 5591 21 2 17
GSE54993 PRKDC 5591 1 16 53
GSE54994 PRKDC 5591 27 1 25
GSE60625 PRKDC 5591 0 5 6
GSE74703 PRKDC 5591 12 2 22
GSE74704 PRKDC 5591 12 0 8
TCGA PRKDC 5591 47 5 44

Total number of gains: 187; Total number of losses: 39; Total Number of normals: 262.  

 

Somatic mutations of PRKDC:

 

Generating mutation plots.

 

Highly correlated genes for PRKDC:

 

Showing top 20/2318 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PRKDCMTBP0.820719505
PRKDCMCM40.8199812012
PRKDCATAD20.80313411011
PRKDCRUVBL10.79020611011
PRKDCNOP560.782628303
PRKDCFANCB0.779127505
PRKDCSNAP470.777453303
PRKDCBUB1B0.775449808
PRKDCPPP1R9B0.774238303
PRKDCCCNB20.77385411011
PRKDCCENPF0.77314312011
PRKDCTBC1D310.77267210010
PRKDCGINS10.76671711011
PRKDCASPM0.76441912011
PRKDCMIS18A0.763083808
PRKDCTPX20.7630612012
PRKDCCKS1B0.76301112011
PRKDCMTERF30.762471808
PRKDCMMS22L0.761929303
PRKDCFAM89A0.761012303

For details and further investigation, click here