TMEM208

 

Full name: transmembrane protein 208 Alias Symbol: HSPC171
Type: protein-coding gene Cytoband: 16q22.1
Entrez ID: 29100 HGNC ID: HGNC:25015 Ensembl Gene: ENSG00000168701 OMIM ID: 
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of TMEM208:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TMEM208 29100 221597_s_at 0.4352 0.2941
GSE20347 TMEM208 29100 221597_s_at 0.4546 0.0029
GSE23400 TMEM208 29100 221597_s_at 0.4820 0.0000
GSE26886 TMEM208 29100 221597_s_at -0.0014 0.9957
GSE29001 TMEM208 29100 221597_s_at 0.3376 0.2819
GSE38129 TMEM208 29100 221597_s_at 0.6007 0.0000
GSE45670 TMEM208 29100 221597_s_at 0.5172 0.0002
GSE53622 TMEM208 29100 52068 0.3502 0.0000
GSE53624 TMEM208 29100 52068 0.6349 0.0000
GSE63941 TMEM208 29100 221597_s_at -0.3651 0.2747
GSE77861 TMEM208 29100 221597_s_at 0.3144 0.0587
GSE97050 TMEM208 29100 A_23_P206369 0.1532 0.5137
SRP007169 TMEM208 29100 RNAseq -0.0609 0.8560
SRP008496 TMEM208 29100 RNAseq -0.0386 0.8746
SRP064894 TMEM208 29100 RNAseq 0.6752 0.0101
SRP133303 TMEM208 29100 RNAseq 0.6364 0.0000
SRP159526 TMEM208 29100 RNAseq 0.5963 0.0105
SRP193095 TMEM208 29100 RNAseq 0.0737 0.5773
SRP219564 TMEM208 29100 RNAseq 0.6323 0.0935
TCGA TMEM208 29100 RNAseq 0.1155 0.0743

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by TMEM208 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TMEM208:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TMEM208 29100 9 2 19
GSE20123 TMEM208 29100 9 2 19
GSE43470 TMEM208 29100 1 9 33
GSE46452 TMEM208 29100 38 1 20
GSE47630 TMEM208 29100 10 8 22
GSE54993 TMEM208 29100 2 4 64
GSE54994 TMEM208 29100 8 10 35
GSE60625 TMEM208 29100 4 0 7
GSE74703 TMEM208 29100 1 6 29
GSE74704 TMEM208 29100 5 1 14
TCGA TMEM208 29100 29 12 55

Total number of gains: 116; Total number of losses: 55; Total Number of normals: 317.  

 

Somatic mutations of TMEM208:

 

Generating mutation plots.

 

Highly correlated genes for TMEM208:

 

Showing top 20/1212 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TMEM208PRELID10.80023303
TMEM208IRF2BPL0.781486303
TMEM208NFKB10.744033303
TMEM208LRRC590.74342808
TMEM208SDHAF20.74229403
TMEM208CIB10.73731303
TMEM208HRH10.721735303
TMEM208FBXO390.719789403
TMEM208CASC40.715798303
TMEM208CIAO10.712149404
TMEM208AP1G10.707602403
TMEM208PSMA70.707005909
TMEM208PCBP20.705235505
TMEM208HAS30.704723504
TMEM208TMEM540.697367404
TMEM208CD99L20.697091303
TMEM208DDX280.69608212011
TMEM208TMEM600.696071303
TMEM208COMMD20.69571403
TMEM208NFATC30.693912808

For details and further investigation, click here