PTPN11

 

Full name: protein tyrosine phosphatase non-receptor type 11 Alias Symbol: BPTP3|SH-PTP2|SHP-2|PTP2C|SHP2
Type: protein-coding gene Cytoband: 12q24.13
Entrez ID: 5781 HGNC ID: HGNC:9644 Ensembl Gene: ENSG00000179295 OMIM ID: 176876
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 249/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

PTPN11 involved pathways:

KEGG pathway Description View
hsa04014Ras signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04360Axon guidance
hsa04630Jak-STAT signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04722Neurotrophin signaling pathway
hsa04920Adipocytokine signaling pathway
hsa04931Insulin resistance
hsa05205Proteoglycans in cancer
hsa05211Renal cell carcinoma
hsa05220Chronic myeloid leukemia

 

Expression of PTPN11:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PTPN11 5781 212610_at 0.1024 0.8618
GSE20347 PTPN11 5781 212610_at 0.1812 0.1943
GSE23400 PTPN11 5781 212610_at 0.2834 0.0005
GSE26886 PTPN11 5781 212610_at 0.2821 0.0685
GSE29001 PTPN11 5781 212610_at 0.4754 0.0142
GSE38129 PTPN11 5781 212610_at 0.0790 0.5697
GSE45670 PTPN11 5781 212610_at -0.0451 0.7370
GSE53622 PTPN11 5781 107187 0.1302 0.0678
GSE53624 PTPN11 5781 54927 0.2912 0.0000
GSE63941 PTPN11 5781 212610_at -0.4928 0.0425
GSE77861 PTPN11 5781 212610_at 0.3340 0.0999
GSE97050 PTPN11 A_21_P0012454 -0.0722 0.8312
SRP007169 PTPN11 5781 RNAseq 1.7557 0.0000
SRP008496 PTPN11 5781 RNAseq 1.7134 0.0000
SRP064894 PTPN11 5781 RNAseq 0.0893 0.7217
SRP133303 PTPN11 5781 RNAseq 0.3235 0.0488
SRP159526 PTPN11 5781 RNAseq 0.2973 0.2103
SRP193095 PTPN11 5781 RNAseq 0.3739 0.0001
SRP219564 PTPN11 5781 RNAseq -0.3845 0.2969
TCGA PTPN11 5781 RNAseq -0.0640 0.1155

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by PTPN11 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PTPN11:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PTPN11 5781 4 3 23
GSE20123 PTPN11 5781 4 3 23
GSE43470 PTPN11 5781 2 1 40
GSE46452 PTPN11 5781 9 1 49
GSE47630 PTPN11 5781 9 3 28
GSE54993 PTPN11 5781 0 5 65
GSE54994 PTPN11 5781 4 2 47
GSE60625 PTPN11 5781 0 0 11
GSE74703 PTPN11 5781 2 0 34
GSE74704 PTPN11 5781 2 2 16
TCGA PTPN11 5781 22 11 63

Total number of gains: 58; Total number of losses: 31; Total Number of normals: 399.  

 

Somatic mutations of PTPN11:

 

Generating mutation plots.

 

Highly correlated genes for PTPN11:

 

Showing top 20/978 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PTPN11MAPK10.780794303
PTPN11NOM10.754194303
PTPN11DCAF160.746638303
PTPN11QKI0.735476303
PTPN11CEP440.731458303
PTPN11CRLS10.727834303
PTPN11EXOSC100.711706303
PTPN11HOOK30.711688303
PTPN11PPTC70.706198404
PTPN11FAM160B10.699427403
PTPN11RBM70.69844303
PTPN11BTN3A20.695031303
PTPN11FGF70.691667303
PTPN11MATR30.691402303
PTPN11NUP540.688758505
PTPN11FAM13B0.688166303
PTPN11STX40.687856303
PTPN11NIPA20.684972303
PTPN11CMC10.684628303
PTPN11FITM20.680488403

For details and further investigation, click here