| Full name: syntaxin 4 | Alias Symbol: p35-2 | ||
| Type: protein-coding gene | Cytoband: 16p11.2 | ||
| Entrez ID: 6810 | HGNC ID: HGNC:11439 | Ensembl Gene: ENSG00000103496 | OMIM ID: 186591 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of STX4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | STX4 | 6810 | 203530_s_at | 0.0488 | 0.9245 | |
| GSE20347 | STX4 | 6810 | 203530_s_at | -0.0221 | 0.8700 | |
| GSE23400 | STX4 | 6810 | 203530_s_at | 0.3598 | 0.0000 | |
| GSE26886 | STX4 | 6810 | 203530_s_at | -0.6359 | 0.0041 | |
| GSE29001 | STX4 | 6810 | 203530_s_at | 0.3154 | 0.1585 | |
| GSE38129 | STX4 | 6810 | 203530_s_at | 0.0215 | 0.8692 | |
| GSE45670 | STX4 | 6810 | 203530_s_at | 0.0836 | 0.4905 | |
| GSE53622 | STX4 | 6810 | 38309 | -0.0265 | 0.7518 | |
| GSE53624 | STX4 | 6810 | 38309 | 0.1768 | 0.0119 | |
| GSE63941 | STX4 | 6810 | 203530_s_at | -0.3063 | 0.5061 | |
| GSE77861 | STX4 | 6810 | 203530_s_at | 0.0029 | 0.9929 | |
| GSE97050 | STX4 | 6810 | A_23_P256375 | 0.2435 | 0.3261 | |
| SRP007169 | STX4 | 6810 | RNAseq | 0.0717 | 0.8788 | |
| SRP008496 | STX4 | 6810 | RNAseq | 0.2203 | 0.5221 | |
| SRP064894 | STX4 | 6810 | RNAseq | 0.3961 | 0.0258 | |
| SRP133303 | STX4 | 6810 | RNAseq | 0.2251 | 0.0844 | |
| SRP159526 | STX4 | 6810 | RNAseq | -0.1481 | 0.4975 | |
| SRP193095 | STX4 | 6810 | RNAseq | 0.1118 | 0.3742 | |
| SRP219564 | STX4 | 6810 | RNAseq | 0.1829 | 0.4085 | |
| TCGA | STX4 | 6810 | RNAseq | 0.0391 | 0.4868 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by STX4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of STX4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | STX4 | 6810 | 5 | 5 | 20 | |
| GSE20123 | STX4 | 6810 | 5 | 4 | 21 | |
| GSE43470 | STX4 | 6810 | 3 | 3 | 37 | |
| GSE46452 | STX4 | 6810 | 38 | 1 | 20 | |
| GSE47630 | STX4 | 6810 | 11 | 7 | 22 | |
| GSE54993 | STX4 | 6810 | 2 | 5 | 63 | |
| GSE54994 | STX4 | 6810 | 5 | 9 | 39 | |
| GSE60625 | STX4 | 6810 | 4 | 0 | 7 | |
| GSE74703 | STX4 | 6810 | 3 | 2 | 31 | |
| GSE74704 | STX4 | 6810 | 3 | 2 | 15 | |
| TCGA | STX4 | 6810 | 20 | 10 | 66 |
Total number of gains: 99; Total number of losses: 48; Total Number of normals: 341.
Somatic mutations of STX4:
Generating mutation plots.
Highly correlated genes for STX4:
Showing top 20/239 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| STX4 | FASTKD2 | 0.781489 | 3 | 0 | 3 |
| STX4 | SPNS1 | 0.747412 | 3 | 0 | 3 |
| STX4 | CYB5B | 0.719915 | 3 | 0 | 3 |
| STX4 | MFSD3 | 0.71336 | 3 | 0 | 3 |
| STX4 | LYSMD3 | 0.71276 | 3 | 0 | 3 |
| STX4 | HSD17B12 | 0.711314 | 3 | 0 | 3 |
| STX4 | ZFPL1 | 0.707747 | 4 | 0 | 3 |
| STX4 | WDR4 | 0.700844 | 3 | 0 | 3 |
| STX4 | ALDH1A3 | 0.700036 | 3 | 0 | 3 |
| STX4 | ITPRIPL2 | 0.690023 | 3 | 0 | 3 |
| STX4 | HAX1 | 0.688323 | 3 | 0 | 3 |
| STX4 | PTPN11 | 0.687856 | 3 | 0 | 3 |
| STX4 | RBBP5 | 0.683423 | 3 | 0 | 3 |
| STX4 | KTI12 | 0.677079 | 3 | 0 | 3 |
| STX4 | IPMK | 0.675974 | 3 | 0 | 3 |
| STX4 | SRPRB | 0.674691 | 3 | 0 | 3 |
| STX4 | N4BP1 | 0.670336 | 3 | 0 | 3 |
| STX4 | MRPL44 | 0.668292 | 4 | 0 | 3 |
| STX4 | TMCC1 | 0.667598 | 3 | 0 | 3 |
| STX4 | OSBPL2 | 0.665191 | 4 | 0 | 3 |
For details and further investigation, click here
