| Full name: phosphofructokinase, muscle | Alias Symbol: PFK-1|PPP1R122 | ||
| Type: protein-coding gene | Cytoband: 12q13.11 | ||
| Entrez ID: 5213 | HGNC ID: HGNC:8877 | Ensembl Gene: ENSG00000152556 | OMIM ID: 610681 |
| Drug and gene relationship at DGIdb | |||
PFKM involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04152 | AMPK signaling pathway |
Expression of PFKM:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PFKM | 5213 | 210976_s_at | 0.0336 | 0.9646 | |
| GSE20347 | PFKM | 5213 | 210976_s_at | 0.6330 | 0.0004 | |
| GSE23400 | PFKM | 5213 | 210976_s_at | 0.2013 | 0.0467 | |
| GSE26886 | PFKM | 5213 | 210976_s_at | -0.0194 | 0.9632 | |
| GSE29001 | PFKM | 5213 | 210976_s_at | 0.4148 | 0.3192 | |
| GSE38129 | PFKM | 5213 | 210976_s_at | 0.3175 | 0.1346 | |
| GSE45670 | PFKM | 5213 | 210976_s_at | 0.0274 | 0.9095 | |
| GSE53622 | PFKM | 5213 | 27800 | 0.0312 | 0.8019 | |
| GSE53624 | PFKM | 5213 | 27800 | 0.3993 | 0.0000 | |
| GSE63941 | PFKM | 5213 | 210976_s_at | -0.0587 | 0.9005 | |
| GSE77861 | PFKM | 5213 | 210976_s_at | 0.4284 | 0.1522 | |
| GSE97050 | PFKM | 5213 | A_24_P98914 | -0.6898 | 0.1726 | |
| SRP007169 | PFKM | 5213 | RNAseq | 0.6161 | 0.1244 | |
| SRP008496 | PFKM | 5213 | RNAseq | 0.5483 | 0.0475 | |
| SRP064894 | PFKM | 5213 | RNAseq | 0.1495 | 0.2470 | |
| SRP133303 | PFKM | 5213 | RNAseq | 0.1868 | 0.3884 | |
| SRP159526 | PFKM | 5213 | RNAseq | 0.1571 | 0.4773 | |
| SRP193095 | PFKM | 5213 | RNAseq | 0.5487 | 0.0000 | |
| SRP219564 | PFKM | 5213 | RNAseq | -0.3584 | 0.5360 | |
| TCGA | PFKM | 5213 | RNAseq | -0.0787 | 0.2537 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PFKM expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PFKM:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PFKM | 5213 | 6 | 1 | 23 | |
| GSE20123 | PFKM | 5213 | 6 | 1 | 23 | |
| GSE43470 | PFKM | 5213 | 3 | 1 | 39 | |
| GSE46452 | PFKM | 5213 | 8 | 1 | 50 | |
| GSE47630 | PFKM | 5213 | 11 | 2 | 27 | |
| GSE54993 | PFKM | 5213 | 0 | 5 | 65 | |
| GSE54994 | PFKM | 5213 | 6 | 1 | 46 | |
| GSE60625 | PFKM | 5213 | 0 | 0 | 11 | |
| GSE74703 | PFKM | 5213 | 3 | 1 | 32 | |
| GSE74704 | PFKM | 5213 | 4 | 1 | 15 | |
| TCGA | PFKM | 5213 | 16 | 12 | 68 |
Total number of gains: 63; Total number of losses: 26; Total Number of normals: 399.
Somatic mutations of PFKM:
Generating mutation plots.
Highly correlated genes for PFKM:
Showing top 20/878 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PFKM | C20orf194 | 0.826887 | 3 | 0 | 3 |
| PFKM | HNRNPUL2 | 0.730222 | 3 | 0 | 3 |
| PFKM | MPHOSPH6 | 0.726519 | 3 | 0 | 3 |
| PFKM | RNF121 | 0.724788 | 3 | 0 | 3 |
| PFKM | PTPN14 | 0.717584 | 4 | 0 | 4 |
| PFKM | C1orf112 | 0.717457 | 3 | 0 | 3 |
| PFKM | PHF5A | 0.71632 | 3 | 0 | 3 |
| PFKM | FAM20C | 0.707068 | 3 | 0 | 3 |
| PFKM | KDSR | 0.706696 | 3 | 0 | 3 |
| PFKM | CLIC4 | 0.705851 | 6 | 0 | 5 |
| PFKM | CDKN1C | 0.705495 | 3 | 0 | 3 |
| PFKM | LSM2 | 0.704715 | 5 | 0 | 5 |
| PFKM | MCAM | 0.703091 | 5 | 0 | 4 |
| PFKM | DCAF16 | 0.699521 | 3 | 0 | 3 |
| PFKM | NAP1L4 | 0.698731 | 3 | 0 | 3 |
| PFKM | BCAS3 | 0.696255 | 3 | 0 | 3 |
| PFKM | ADAR | 0.695661 | 3 | 0 | 3 |
| PFKM | HABP4 | 0.694111 | 4 | 0 | 3 |
| PFKM | SPOPL | 0.691718 | 4 | 0 | 3 |
| PFKM | CCT6A | 0.691582 | 3 | 0 | 3 |
For details and further investigation, click here
