| Full name: protein tyrosine phosphatase receptor type A | Alias Symbol: LRP|HLPR|HPTPA|RPTPA | ||
| Type: protein-coding gene | Cytoband: 20p13 | ||
| Entrez ID: 5786 | HGNC ID: HGNC:9664 | Ensembl Gene: ENSG00000132670 | OMIM ID: 176884 |
| Drug and gene relationship at DGIdb | |||
Expression of PTPRA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PTPRA | 5786 | 213795_s_at | 0.0042 | 0.9951 | |
| GSE20347 | PTPRA | 5786 | 213795_s_at | -0.0784 | 0.6666 | |
| GSE23400 | PTPRA | 5786 | 213795_s_at | 0.1315 | 0.0678 | |
| GSE26886 | PTPRA | 5786 | 213795_s_at | 0.4163 | 0.1291 | |
| GSE29001 | PTPRA | 5786 | 213795_s_at | -0.0059 | 0.9834 | |
| GSE38129 | PTPRA | 5786 | 213795_s_at | 0.0415 | 0.7411 | |
| GSE45670 | PTPRA | 5786 | 213795_s_at | 0.1911 | 0.1849 | |
| GSE53622 | PTPRA | 5786 | 24911 | 0.1191 | 0.0399 | |
| GSE53624 | PTPRA | 5786 | 24911 | 0.0039 | 0.9543 | |
| GSE63941 | PTPRA | 5786 | 213795_s_at | 0.0242 | 0.9571 | |
| GSE77861 | PTPRA | 5786 | 213795_s_at | -0.0864 | 0.7796 | |
| GSE97050 | PTPRA | 5786 | A_23_P28869 | 0.0557 | 0.9119 | |
| SRP007169 | PTPRA | 5786 | RNAseq | -1.2585 | 0.0015 | |
| SRP008496 | PTPRA | 5786 | RNAseq | -0.9393 | 0.0000 | |
| SRP064894 | PTPRA | 5786 | RNAseq | 0.0496 | 0.7067 | |
| SRP133303 | PTPRA | 5786 | RNAseq | 0.0386 | 0.7692 | |
| SRP159526 | PTPRA | 5786 | RNAseq | 0.0822 | 0.5728 | |
| SRP193095 | PTPRA | 5786 | RNAseq | -0.1169 | 0.1839 | |
| SRP219564 | PTPRA | 5786 | RNAseq | -0.0192 | 0.9124 | |
| TCGA | PTPRA | 5786 | RNAseq | -0.0023 | 0.9594 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by PTPRA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PTPRA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PTPRA | 5786 | 12 | 3 | 15 | |
| GSE20123 | PTPRA | 5786 | 13 | 3 | 14 | |
| GSE43470 | PTPRA | 5786 | 10 | 1 | 32 | |
| GSE46452 | PTPRA | 5786 | 26 | 1 | 32 | |
| GSE47630 | PTPRA | 5786 | 18 | 4 | 18 | |
| GSE54993 | PTPRA | 5786 | 2 | 14 | 54 | |
| GSE54994 | PTPRA | 5786 | 24 | 2 | 27 | |
| GSE60625 | PTPRA | 5786 | 0 | 0 | 11 | |
| GSE74703 | PTPRA | 5786 | 9 | 1 | 26 | |
| GSE74704 | PTPRA | 5786 | 8 | 1 | 11 | |
| TCGA | PTPRA | 5786 | 40 | 12 | 44 |
Total number of gains: 162; Total number of losses: 42; Total Number of normals: 284.
Somatic mutations of PTPRA:
Generating mutation plots.
Highly correlated genes for PTPRA:
Showing top 20/129 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PTPRA | TCHP | 0.779409 | 3 | 0 | 3 |
| PTPRA | RBM26 | 0.77625 | 3 | 0 | 3 |
| PTPRA | LUC7L2 | 0.754075 | 3 | 0 | 3 |
| PTPRA | POLI | 0.750574 | 3 | 0 | 3 |
| PTPRA | UCKL1 | 0.745875 | 3 | 0 | 3 |
| PTPRA | MBD2 | 0.728372 | 4 | 0 | 4 |
| PTPRA | WDR7 | 0.695488 | 4 | 0 | 3 |
| PTPRA | ZNF343 | 0.685736 | 4 | 0 | 3 |
| PTPRA | PIGX | 0.684485 | 3 | 0 | 3 |
| PTPRA | C21orf91 | 0.684232 | 3 | 0 | 3 |
| PTPRA | CCDC102B | 0.681715 | 3 | 0 | 3 |
| PTPRA | CYP4X1 | 0.68126 | 3 | 0 | 3 |
| PTPRA | PRSS12 | 0.679711 | 3 | 0 | 3 |
| PTPRA | NDN | 0.67826 | 4 | 0 | 4 |
| PTPRA | MBD1 | 0.671336 | 4 | 0 | 3 |
| PTPRA | GIN1 | 0.670666 | 3 | 0 | 3 |
| PTPRA | VPS41 | 0.666224 | 4 | 0 | 3 |
| PTPRA | MRPL9 | 0.665082 | 3 | 0 | 3 |
| PTPRA | OR2F1 | 0.662363 | 3 | 0 | 3 |
| PTPRA | SLAIN1 | 0.662193 | 3 | 0 | 3 |
For details and further investigation, click here
