FAP

 

Full name: fibroblast activation protein alpha Alias Symbol: DPPIV
Type: protein-coding gene Cytoband: 2q24.2
Entrez ID: 2191 HGNC ID: HGNC:3590 Ensembl Gene: ENSG00000078098 OMIM ID: 600403
Drug and gene relationship at DGIdb

 

Expression of FAP:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 FAP 2191 209955_s_at 1.4827 0.1173
GSE20347 FAP 2191 209955_s_at 1.2921 0.0000
GSE23400 FAP 2191 209955_s_at 1.2914 0.0000
GSE26886 FAP 2191 209955_s_at 1.1404 0.0036
GSE29001 FAP 2191 209955_s_at 0.7917 0.0034
GSE38129 FAP 2191 209955_s_at 1.7507 0.0000
GSE45670 FAP 2191 209955_s_at 0.5508 0.4423
GSE63941 FAP 2191 209955_s_at -6.5512 0.0000
GSE77861 FAP 2191 209955_s_at 0.3241 0.0488
GSE97050 FAP 2191 A_23_P56746 1.1869 0.1156
SRP007169 FAP 2191 RNAseq 5.2633 0.0000
SRP008496 FAP 2191 RNAseq 6.4952 0.0000
SRP064894 FAP 2191 RNAseq 3.4610 0.0000
SRP133303 FAP 2191 RNAseq 3.5682 0.0000
SRP159526 FAP 2191 RNAseq 2.6269 0.0000
SRP219564 FAP 2191 RNAseq 1.8226 0.0468
TCGA FAP 2191 RNAseq 1.4669 0.0000

Upregulated datasets: 11; Downregulated datasets: 1.  


 

Survival by FAP expression:

 

TCGA

 

Note: Click image to view full size file.  


Copy number change of FAP:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 FAP 2191 4 1 25
GSE20123 FAP 2191 4 1 25
GSE43470 FAP 2191 4 1 38
GSE46452 FAP 2191 1 4 54
GSE47630 FAP 2191 5 3 32
GSE54993 FAP 2191 0 5 65
GSE54994 FAP 2191 11 2 40
GSE60625 FAP 2191 0 3 8
GSE74703 FAP 2191 3 1 32
GSE74704 FAP 2191 3 0 17
TCGA FAP 2191 23 10 63

Total number of gains: 58; Total number of losses: 31; Total Number of normals: 399.  


 

Somatic mutations of FAP:

 

Generating mutation plots.

 

Highly correlated genes for FAP:

 

Showing top 20/996 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
FAPCOL5A20.8517511011
FAPCOL5A10.84419911011
FAPCOL1A20.84091711011
FAPCOL6A30.83723311011
FAPPOSTN0.83479311011
FAPVCAN0.83349911011
FAPINHBA0.8302210010
FAPADAMTS120.821195606
FAPSPARC0.82078711010
FAPCOL1A10.81977310010
FAPCTSK0.81370111011
FAPCOL3A10.81094511011
FAPOLFML2B0.80954611011
FAPBGN0.80881711011
FAPLOXL20.80827210010
FAPTHY10.80802211011
FAPNID20.80633910010
FAPNOX40.79931811011
FAPSULF10.79895911011
FAPCDH110.79721311011

For details and further investigation, click here