| Full name: chondroitin sulfate synthase 3 | Alias Symbol: CSS3|CHSY-2 | ||
| Type: protein-coding gene | Cytoband: 5q23.3 | ||
| Entrez ID: 337876 | HGNC ID: HGNC:24293 | Ensembl Gene: ENSG00000198108 | OMIM ID: 609963 |
| Drug and gene relationship at DGIdb | |||
Expression of CHSY3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CHSY3 | 337876 | 242100_at | 0.3441 | 0.6532 | |
| GSE26886 | CHSY3 | 337876 | 242100_at | 0.6956 | 0.0003 | |
| GSE45670 | CHSY3 | 337876 | 242100_at | 0.1507 | 0.6956 | |
| GSE53622 | CHSY3 | 337876 | 86429 | 0.9915 | 0.0000 | |
| GSE53624 | CHSY3 | 337876 | 86429 | 1.1801 | 0.0000 | |
| GSE63941 | CHSY3 | 337876 | 242100_at | -3.2361 | 0.0001 | |
| GSE77861 | CHSY3 | 337876 | 242100_at | -0.0685 | 0.4834 | |
| GSE97050 | CHSY3 | 337876 | A_23_P368886 | 0.2138 | 0.2628 | |
| SRP007169 | CHSY3 | 337876 | RNAseq | 3.7098 | 0.0001 | |
| SRP008496 | CHSY3 | 337876 | RNAseq | 3.7613 | 0.0000 | |
| SRP064894 | CHSY3 | 337876 | RNAseq | 2.2414 | 0.0000 | |
| SRP133303 | CHSY3 | 337876 | RNAseq | 1.3429 | 0.0000 | |
| SRP159526 | CHSY3 | 337876 | RNAseq | 1.0687 | 0.0431 | |
| SRP219564 | CHSY3 | 337876 | RNAseq | 1.0115 | 0.0803 | |
| TCGA | CHSY3 | 337876 | RNAseq | 0.6385 | 0.0017 |
Upregulated datasets: 6; Downregulated datasets: 1.
Survival by CHSY3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CHSY3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CHSY3 | 337876 | 1 | 12 | 17 | |
| GSE20123 | CHSY3 | 337876 | 1 | 12 | 17 | |
| GSE43470 | CHSY3 | 337876 | 3 | 8 | 32 | |
| GSE46452 | CHSY3 | 337876 | 0 | 27 | 32 | |
| GSE47630 | CHSY3 | 337876 | 0 | 21 | 19 | |
| GSE54993 | CHSY3 | 337876 | 9 | 1 | 60 | |
| GSE54994 | CHSY3 | 337876 | 2 | 14 | 37 | |
| GSE60625 | CHSY3 | 337876 | 0 | 0 | 11 | |
| GSE74703 | CHSY3 | 337876 | 2 | 6 | 28 | |
| GSE74704 | CHSY3 | 337876 | 1 | 6 | 13 | |
| TCGA | CHSY3 | 337876 | 4 | 39 | 53 |
Total number of gains: 23; Total number of losses: 146; Total Number of normals: 319.
Somatic mutations of CHSY3:
Generating mutation plots.
Highly correlated genes for CHSY3:
Showing top 20/372 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CHSY3 | ATP6V0D2 | 0.770454 | 3 | 0 | 3 |
| CHSY3 | PCOLCE | 0.750134 | 7 | 0 | 7 |
| CHSY3 | KCND2 | 0.745539 | 7 | 0 | 7 |
| CHSY3 | CTSK | 0.738378 | 7 | 0 | 7 |
| CHSY3 | TNFAIP6 | 0.732929 | 7 | 0 | 6 |
| CHSY3 | NID2 | 0.727207 | 6 | 0 | 6 |
| CHSY3 | VCAN | 0.726343 | 7 | 0 | 7 |
| CHSY3 | CDH11 | 0.725867 | 7 | 0 | 7 |
| CHSY3 | LINC00597 | 0.71356 | 3 | 0 | 3 |
| CHSY3 | GPX8 | 0.712584 | 6 | 0 | 5 |
| CHSY3 | KLK14 | 0.711242 | 3 | 0 | 3 |
| CHSY3 | TBX2 | 0.710078 | 4 | 0 | 4 |
| CHSY3 | PTX3 | 0.709154 | 3 | 0 | 3 |
| CHSY3 | PRRX1 | 0.709076 | 7 | 0 | 7 |
| CHSY3 | DACT1 | 0.708848 | 7 | 0 | 7 |
| CHSY3 | OLFML2B | 0.707192 | 8 | 0 | 7 |
| CHSY3 | LIM2 | 0.700665 | 3 | 0 | 3 |
| CHSY3 | FNDC1 | 0.699695 | 7 | 0 | 6 |
| CHSY3 | PDE4A | 0.699047 | 3 | 0 | 3 |
| CHSY3 | DPP4 | 0.698038 | 6 | 0 | 5 |
For details and further investigation, click here
