DACT1

 

Full name: dishevelled binding antagonist of beta catenin 1 Alias Symbol: DAPPER1|THYEX3|HDPR1|DAPPER|FRODO
Type: protein-coding gene Cytoband: 14q23.1
Entrez ID: 51339 HGNC ID: HGNC:17748 Ensembl Gene: ENSG00000165617 OMIM ID: 607861
Drug and gene relationship at DGIdb

 

Expression of DACT1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 DACT1 51339 219179_at 0.8569 0.1854
GSE20347 DACT1 51339 219179_at 1.1045 0.0001
GSE23400 DACT1 51339 219179_at 0.4924 0.0000
GSE26886 DACT1 51339 219179_at 1.3663 0.0007
GSE29001 DACT1 51339 219179_at 1.2523 0.0007
GSE38129 DACT1 51339 219179_at 0.9277 0.0069
GSE45670 DACT1 51339 219179_at -0.9920 0.1225
GSE53622 DACT1 51339 25682 1.1196 0.0000
GSE53624 DACT1 51339 25682 1.4842 0.0000
GSE63941 DACT1 51339 219179_at -5.2698 0.0001
GSE77861 DACT1 51339 219179_at 0.2302 0.3145
GSE97050 DACT1 51339 A_23_P65518 0.3783 0.1657
SRP007169 DACT1 51339 RNAseq 6.0066 0.0000
SRP008496 DACT1 51339 RNAseq 5.3592 0.0000
SRP064894 DACT1 51339 RNAseq 1.0136 0.0157
SRP133303 DACT1 51339 RNAseq 1.8765 0.0000
SRP159526 DACT1 51339 RNAseq 0.9154 0.0629
SRP219564 DACT1 51339 RNAseq 0.7351 0.1892
TCGA DACT1 51339 RNAseq -0.1265 0.5313

Upregulated datasets: 9; Downregulated datasets: 1.  

 

Survival by DACT1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of DACT1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 DACT1 51339 8 3 19
GSE20123 DACT1 51339 7 3 20
GSE43470 DACT1 51339 8 2 33
GSE46452 DACT1 51339 16 3 40
GSE47630 DACT1 51339 11 9 20
GSE54993 DACT1 51339 3 8 59
GSE54994 DACT1 51339 19 4 30
GSE60625 DACT1 51339 0 2 9
GSE74703 DACT1 51339 7 2 27
GSE74704 DACT1 51339 3 2 15
TCGA DACT1 51339 32 14 50

Total number of gains: 114; Total number of losses: 52; Total Number of normals: 322.  

 

Somatic mutations of DACT1:

 

Generating mutation plots.

 

Highly correlated genes for DACT1:

 

Showing top 20/1202 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
DACT1FAP0.79144911011
DACT1PCOLCE0.77234213013
DACT1VCAN0.76215713013
DACT1FCGR3A0.758124303
DACT1COL5A10.75547913013
DACT1NOX40.75306213012
DACT1PDGFRB0.75258612012
DACT1LRRC340.751725303
DACT1NNMT0.749586404
DACT1CHN10.74710513012
DACT1COL6A30.7470113013
DACT1ISLR0.74247713013
DACT1C11orf960.741559404
DACT1CTSK0.73977213013
DACT1MMP20.73886811011
DACT1RHOBTB10.73669813013
DACT1TMEM2630.736286707
DACT1POSTN0.733713013
DACT1CSGALNACT20.73349111011
DACT1TNFAIP60.73179313012

For details and further investigation, click here