COL11A1

 

Full name: collagen type XI alpha 1 chain Alias Symbol: STL2|CO11A1
Type: protein-coding gene Cytoband: 1p21.1
Entrez ID: 1301 HGNC ID: HGNC:2186 Ensembl Gene: ENSG00000060718 OMIM ID: 120280
Drug and gene relationship at DGIdb

 

Expression of COL11A1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 COL11A1 1301 204320_at 3.5085 0.0184
GSE20347 COL11A1 1301 37892_at 4.5327 0.0000
GSE23400 COL11A1 1301 37892_at 2.4781 0.0000
GSE26886 COL11A1 1301 204320_at 2.5585 0.0004
GSE29001 COL11A1 1301 204320_at 1.8032 0.0001
GSE38129 COL11A1 1301 37892_at 4.6951 0.0000
GSE45670 COL11A1 1301 204320_at 1.2498 0.0282
GSE53622 COL11A1 1301 11239 1.5082 0.0000
GSE53624 COL11A1 1301 11239 3.8862 0.0000
GSE63941 COL11A1 1301 37892_at -2.9936 0.0030
GSE77861 COL11A1 1301 204320_at 0.2581 0.7853
SRP007169 COL11A1 1301 RNAseq 10.6735 0.0000
SRP008496 COL11A1 1301 RNAseq 9.9268 0.0000
SRP133303 COL11A1 1301 RNAseq 8.0980 0.0000
SRP159526 COL11A1 1301 RNAseq 7.2267 0.0000
SRP219564 COL11A1 1301 RNAseq 7.0731 0.0000
TCGA COL11A1 1301 RNAseq 4.2240 0.0000

Upregulated datasets: 15; Downregulated datasets: 1.  

 

Survival by COL11A1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of COL11A1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 COL11A1 1301 0 10 20
GSE20123 COL11A1 1301 0 10 20
GSE43470 COL11A1 1301 0 6 37
GSE46452 COL11A1 1301 1 1 57
GSE47630 COL11A1 1301 9 5 26
GSE54993 COL11A1 1301 0 1 69
GSE54994 COL11A1 1301 6 3 44
GSE60625 COL11A1 1301 0 0 11
GSE74703 COL11A1 1301 0 5 31
GSE74704 COL11A1 1301 0 6 14
TCGA COL11A1 1301 8 24 64

Total number of gains: 24; Total number of losses: 71; Total Number of normals: 393.  

 

Somatic mutations of COL11A1:

 

Generating mutation plots.

 

Highly correlated genes for COL11A1:

 

Showing top 20/749 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
COL11A1COL10A10.8496111011
COL11A1ADAMTS120.81584707
COL11A1MMP110.8018421009
COL11A1POSTN0.77924712012
COL11A1THBS20.76917512011
COL11A1ZNF4690.758783707
COL11A1FAP0.75823710010
COL11A1COL5A20.75787512012
COL11A1LRRC150.75145812011
COL11A1COL1A10.74280711011
COL11A1COL1A20.73922512012
COL11A1COL5A10.73702712012
COL11A1HIC10.734446303
COL11A1VCAN0.72932312012
COL11A1INHBA0.72931511011
COL11A1SPARC0.72589712012
COL11A1COL3A10.72333412012
COL11A1NOX40.72047812012
COL11A1SPP10.719471009
COL11A1MFAP20.71888111011

For details and further investigation, click here