| Full name: pyrroline-5-carboxylate reductase 1 | Alias Symbol: P5C | ||
| Type: protein-coding gene | Cytoband: 17q25.3 | ||
| Entrez ID: 5831 | HGNC ID: HGNC:9721 | Ensembl Gene: ENSG00000183010 | OMIM ID: 179035 |
| Drug and gene relationship at DGIdb | |||
Expression of PYCR1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PYCR1 | 5831 | 202148_s_at | 0.4346 | 0.3379 | |
| GSE20347 | PYCR1 | 5831 | 202148_s_at | 0.5056 | 0.0000 | |
| GSE23400 | PYCR1 | 5831 | 202148_s_at | 0.1888 | 0.0002 | |
| GSE26886 | PYCR1 | 5831 | 202148_s_at | 0.3574 | 0.0117 | |
| GSE29001 | PYCR1 | 5831 | 202148_s_at | 0.3159 | 0.1699 | |
| GSE38129 | PYCR1 | 5831 | 202148_s_at | 0.5641 | 0.0000 | |
| GSE45670 | PYCR1 | 5831 | 202148_s_at | 0.1708 | 0.1751 | |
| GSE53622 | PYCR1 | 5831 | 25911 | 1.7675 | 0.0000 | |
| GSE53624 | PYCR1 | 5831 | 25911 | 1.8146 | 0.0000 | |
| GSE63941 | PYCR1 | 5831 | 202148_s_at | 1.0102 | 0.0217 | |
| GSE77861 | PYCR1 | 5831 | 202148_s_at | 0.2002 | 0.1487 | |
| GSE97050 | PYCR1 | 5831 | A_23_P130194 | 0.3496 | 0.2641 | |
| SRP007169 | PYCR1 | 5831 | RNAseq | 2.2435 | 0.0005 | |
| SRP008496 | PYCR1 | 5831 | RNAseq | 1.9184 | 0.0000 | |
| SRP064894 | PYCR1 | 5831 | RNAseq | 1.1677 | 0.0047 | |
| SRP133303 | PYCR1 | 5831 | RNAseq | 1.5672 | 0.0000 | |
| SRP159526 | PYCR1 | 5831 | RNAseq | 1.9911 | 0.0000 | |
| SRP193095 | PYCR1 | 5831 | RNAseq | 0.5080 | 0.0570 | |
| SRP219564 | PYCR1 | 5831 | RNAseq | 2.2727 | 0.0002 | |
| TCGA | PYCR1 | 5831 | RNAseq | 0.0119 | 0.9062 |
Upregulated datasets: 9; Downregulated datasets: 0.
Survival by PYCR1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PYCR1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PYCR1 | 5831 | 4 | 4 | 22 | |
| GSE20123 | PYCR1 | 5831 | 4 | 4 | 22 | |
| GSE43470 | PYCR1 | 5831 | 3 | 5 | 35 | |
| GSE46452 | PYCR1 | 5831 | 34 | 0 | 25 | |
| GSE47630 | PYCR1 | 5831 | 9 | 2 | 29 | |
| GSE54993 | PYCR1 | 5831 | 2 | 5 | 63 | |
| GSE54994 | PYCR1 | 5831 | 10 | 6 | 37 | |
| GSE60625 | PYCR1 | 5831 | 6 | 0 | 5 | |
| GSE74703 | PYCR1 | 5831 | 3 | 3 | 30 | |
| GSE74704 | PYCR1 | 5831 | 4 | 3 | 13 | |
| TCGA | PYCR1 | 5831 | 25 | 12 | 59 |
Total number of gains: 104; Total number of losses: 44; Total Number of normals: 340.
Somatic mutations of PYCR1:
Generating mutation plots.
Highly correlated genes for PYCR1:
Showing top 20/568 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PYCR1 | C10orf91 | 0.708033 | 3 | 0 | 3 |
| PYCR1 | LRR1 | 0.69328 | 4 | 0 | 4 |
| PYCR1 | CCL26 | 0.676274 | 5 | 0 | 4 |
| PYCR1 | POLE4 | 0.671349 | 5 | 0 | 4 |
| PYCR1 | ZNF620 | 0.668954 | 3 | 0 | 3 |
| PYCR1 | LRWD1 | 0.667817 | 3 | 0 | 3 |
| PYCR1 | VEPH1 | 0.658165 | 3 | 0 | 3 |
| PYCR1 | DIAPH3 | 0.651355 | 4 | 0 | 4 |
| PYCR1 | TAF5 | 0.648568 | 5 | 0 | 5 |
| PYCR1 | CENPM | 0.648176 | 10 | 0 | 8 |
| PYCR1 | ZP3 | 0.645965 | 3 | 0 | 3 |
| PYCR1 | SHMT2 | 0.641337 | 10 | 0 | 9 |
| PYCR1 | IGFLR1 | 0.638396 | 4 | 0 | 3 |
| PYCR1 | SLC5A5 | 0.637371 | 4 | 0 | 3 |
| PYCR1 | TCTE3 | 0.630984 | 4 | 0 | 3 |
| PYCR1 | C19orf48 | 0.629848 | 3 | 0 | 3 |
| PYCR1 | PAM16 | 0.628908 | 9 | 0 | 7 |
| PYCR1 | TK1 | 0.62808 | 11 | 0 | 9 |
| PYCR1 | AK8 | 0.627712 | 4 | 0 | 3 |
| PYCR1 | PCGF1 | 0.627074 | 9 | 0 | 8 |
For details and further investigation, click here
