| Full name: thymidine kinase 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 17q25.3 | ||
| Entrez ID: 7083 | HGNC ID: HGNC:11830 | Ensembl Gene: ENSG00000167900 | OMIM ID: 188300 |
| Drug and gene relationship at DGIdb | |||
Expression of TK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TK1 | 7083 | 1554408_a_at | 1.2009 | 0.0644 | |
| GSE20347 | TK1 | 7083 | 202338_at | 1.2116 | 0.0000 | |
| GSE23400 | TK1 | 7083 | 202338_at | 0.6978 | 0.0000 | |
| GSE26886 | TK1 | 7083 | 202338_at | 0.9391 | 0.0120 | |
| GSE29001 | TK1 | 7083 | 202338_at | 1.2560 | 0.0008 | |
| GSE38129 | TK1 | 7083 | 202338_at | 1.3691 | 0.0000 | |
| GSE45670 | TK1 | 7083 | 202338_at | 1.0092 | 0.0012 | |
| GSE53622 | TK1 | 7083 | 26883 | 1.2906 | 0.0000 | |
| GSE53624 | TK1 | 7083 | 26883 | 1.6737 | 0.0000 | |
| GSE63941 | TK1 | 7083 | 1554408_a_at | 3.7606 | 0.0001 | |
| GSE77861 | TK1 | 7083 | 1554408_a_at | 0.8125 | 0.0110 | |
| GSE97050 | TK1 | 7083 | A_23_P107421 | 0.5765 | 0.1506 | |
| SRP007169 | TK1 | 7083 | RNAseq | 1.6444 | 0.0003 | |
| SRP008496 | TK1 | 7083 | RNAseq | 1.5490 | 0.0000 | |
| SRP064894 | TK1 | 7083 | RNAseq | 2.2106 | 0.0000 | |
| SRP133303 | TK1 | 7083 | RNAseq | 1.8243 | 0.0000 | |
| SRP159526 | TK1 | 7083 | RNAseq | 1.8196 | 0.0000 | |
| SRP193095 | TK1 | 7083 | RNAseq | 1.1993 | 0.0000 | |
| SRP219564 | TK1 | 7083 | RNAseq | 2.0520 | 0.0007 | |
| TCGA | TK1 | 7083 | RNAseq | 0.8547 | 0.0000 |
Upregulated datasets: 14; Downregulated datasets: 0.
Survival by TK1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TK1 | 7083 | 5 | 4 | 21 | |
| GSE20123 | TK1 | 7083 | 5 | 4 | 21 | |
| GSE43470 | TK1 | 7083 | 3 | 4 | 36 | |
| GSE46452 | TK1 | 7083 | 33 | 0 | 26 | |
| GSE47630 | TK1 | 7083 | 8 | 1 | 31 | |
| GSE54993 | TK1 | 7083 | 2 | 5 | 63 | |
| GSE54994 | TK1 | 7083 | 10 | 4 | 39 | |
| GSE60625 | TK1 | 7083 | 6 | 0 | 5 | |
| GSE74703 | TK1 | 7083 | 3 | 2 | 31 | |
| GSE74704 | TK1 | 7083 | 4 | 3 | 13 | |
| TCGA | TK1 | 7083 | 31 | 8 | 57 |
Total number of gains: 110; Total number of losses: 35; Total Number of normals: 343.
Somatic mutations of TK1:
Generating mutation plots.
Highly correlated genes for TK1:
Showing top 20/1219 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TK1 | NCAPH | 0.821212 | 9 | 0 | 9 |
| TK1 | GINS2 | 0.816577 | 13 | 0 | 12 |
| TK1 | MCM2 | 0.816115 | 13 | 0 | 13 |
| TK1 | UBE2C | 0.81314 | 12 | 0 | 12 |
| TK1 | MCM5 | 0.808678 | 12 | 0 | 12 |
| TK1 | BIRC5 | 0.807425 | 12 | 0 | 11 |
| TK1 | MYBL2 | 0.799361 | 12 | 0 | 11 |
| TK1 | CDC45 | 0.79892 | 12 | 0 | 12 |
| TK1 | AURKB | 0.797197 | 13 | 0 | 13 |
| TK1 | CDC20 | 0.796566 | 13 | 0 | 12 |
| TK1 | TPX2 | 0.786667 | 12 | 0 | 12 |
| TK1 | CDKN3 | 0.783316 | 12 | 0 | 12 |
| TK1 | FEN1 | 0.781349 | 11 | 0 | 11 |
| TK1 | KIF4A | 0.780789 | 13 | 0 | 12 |
| TK1 | CENPW | 0.778606 | 6 | 0 | 6 |
| TK1 | CDCA3 | 0.778063 | 12 | 0 | 12 |
| TK1 | KNSTRN | 0.773378 | 7 | 0 | 7 |
| TK1 | UHRF1 | 0.773159 | 9 | 0 | 9 |
| TK1 | CEP55 | 0.772872 | 12 | 0 | 12 |
| TK1 | CENPM | 0.768607 | 12 | 0 | 11 |
For details and further investigation, click here
