| Full name: serine hydroxymethyltransferase 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12q12-q14 | ||
| Entrez ID: 6472 | HGNC ID: HGNC:10852 | Ensembl Gene: ENSG00000182199 | OMIM ID: 138450 |
| Drug and gene relationship at DGIdb | |||
Expression of SHMT2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SHMT2 | 6472 | 214096_s_at | 0.5113 | 0.3302 | |
| GSE20347 | SHMT2 | 6472 | 214096_s_at | 0.7099 | 0.0001 | |
| GSE23400 | SHMT2 | 6472 | 214096_s_at | 0.4990 | 0.0000 | |
| GSE26886 | SHMT2 | 6472 | 214096_s_at | 0.7425 | 0.0004 | |
| GSE29001 | SHMT2 | 6472 | 214096_s_at | 0.4477 | 0.1049 | |
| GSE38129 | SHMT2 | 6472 | 214096_s_at | 0.9804 | 0.0000 | |
| GSE45670 | SHMT2 | 6472 | 214096_s_at | 0.6324 | 0.0008 | |
| GSE53622 | SHMT2 | 6472 | 10115 | 0.6931 | 0.0000 | |
| GSE53624 | SHMT2 | 6472 | 10115 | 0.8433 | 0.0000 | |
| GSE63941 | SHMT2 | 6472 | 214096_s_at | 1.3125 | 0.0055 | |
| GSE77861 | SHMT2 | 6472 | 214096_s_at | 0.2261 | 0.0473 | |
| GSE97050 | SHMT2 | 6472 | A_23_P169629 | 0.6280 | 0.1744 | |
| SRP007169 | SHMT2 | 6472 | RNAseq | 0.4455 | 0.1243 | |
| SRP008496 | SHMT2 | 6472 | RNAseq | 0.1639 | 0.3143 | |
| SRP064894 | SHMT2 | 6472 | RNAseq | 0.5951 | 0.0021 | |
| SRP133303 | SHMT2 | 6472 | RNAseq | 1.0036 | 0.0000 | |
| SRP159526 | SHMT2 | 6472 | RNAseq | 0.6117 | 0.0061 | |
| SRP193095 | SHMT2 | 6472 | RNAseq | 0.4840 | 0.0028 | |
| SRP219564 | SHMT2 | 6472 | RNAseq | 0.7634 | 0.1047 | |
| TCGA | SHMT2 | 6472 | RNAseq | 0.2135 | 0.0002 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by SHMT2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SHMT2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SHMT2 | 6472 | 7 | 1 | 22 | |
| GSE20123 | SHMT2 | 6472 | 7 | 0 | 23 | |
| GSE43470 | SHMT2 | 6472 | 2 | 0 | 41 | |
| GSE46452 | SHMT2 | 6472 | 8 | 1 | 50 | |
| GSE47630 | SHMT2 | 6472 | 10 | 2 | 28 | |
| GSE54993 | SHMT2 | 6472 | 0 | 5 | 65 | |
| GSE54994 | SHMT2 | 6472 | 4 | 1 | 48 | |
| GSE60625 | SHMT2 | 6472 | 0 | 0 | 11 | |
| GSE74703 | SHMT2 | 6472 | 2 | 0 | 34 | |
| GSE74704 | SHMT2 | 6472 | 4 | 0 | 16 | |
| TCGA | SHMT2 | 6472 | 14 | 10 | 72 |
Total number of gains: 58; Total number of losses: 20; Total Number of normals: 410.
Somatic mutations of SHMT2:
Generating mutation plots.
Highly correlated genes for SHMT2:
Showing top 20/1630 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SHMT2 | DKC1 | 0.768608 | 3 | 0 | 3 |
| SHMT2 | UCK2 | 0.752765 | 3 | 0 | 3 |
| SHMT2 | ZBTB9 | 0.748425 | 4 | 0 | 4 |
| SHMT2 | PLEKHH1 | 0.743444 | 3 | 0 | 3 |
| SHMT2 | ZNF267 | 0.741642 | 3 | 0 | 3 |
| SHMT2 | MKI67 | 0.737849 | 9 | 0 | 9 |
| SHMT2 | BIRC5 | 0.736897 | 10 | 0 | 9 |
| SHMT2 | SLC39A3 | 0.736067 | 3 | 0 | 3 |
| SHMT2 | PTBP1 | 0.727372 | 11 | 0 | 11 |
| SHMT2 | TBC1D22A | 0.726846 | 3 | 0 | 3 |
| SHMT2 | CEP55 | 0.72119 | 10 | 0 | 9 |
| SHMT2 | MELK | 0.719216 | 10 | 0 | 9 |
| SHMT2 | HJURP | 0.717049 | 9 | 0 | 9 |
| SHMT2 | XPOT | 0.715724 | 11 | 0 | 10 |
| SHMT2 | ANAPC1 | 0.71431 | 3 | 0 | 3 |
| SHMT2 | CDCA8 | 0.713212 | 9 | 0 | 9 |
| SHMT2 | NOSIP | 0.712868 | 3 | 0 | 3 |
| SHMT2 | CMIP | 0.711636 | 4 | 0 | 4 |
| SHMT2 | NAA60 | 0.711215 | 3 | 0 | 3 |
| SHMT2 | SLC30A7 | 0.710195 | 4 | 0 | 3 |
For details and further investigation, click here
