CENPM

 

Full name: centromere protein M Alias Symbol: Pane1|CENP-M|MGC861
Type: protein-coding gene Cytoband: 22q13.2
Entrez ID: 79019 HGNC ID: HGNC:18352 Ensembl Gene: ENSG00000100162 OMIM ID: 610152
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of CENPM:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CENPM 79019 218741_at 0.9664 0.0265
GSE20347 CENPM 79019 218741_at 1.1108 0.0000
GSE23400 CENPM 79019 218741_at 0.7001 0.0000
GSE26886 CENPM 79019 218741_at 0.8436 0.0001
GSE29001 CENPM 79019 218741_at 0.8524 0.0054
GSE38129 CENPM 79019 218741_at 1.2618 0.0000
GSE45670 CENPM 79019 218741_at 0.9509 0.0000
GSE53622 CENPM 79019 77080 1.3402 0.0000
GSE53624 CENPM 79019 77080 1.4215 0.0000
GSE63941 CENPM 79019 218741_at 2.4436 0.0003
GSE77861 CENPM 79019 218741_at 0.6465 0.0022
GSE97050 CENPM 79019 A_24_P399888 1.1912 0.1388
SRP007169 CENPM 79019 RNAseq 1.0152 0.0354
SRP064894 CENPM 79019 RNAseq 1.4920 0.0000
SRP133303 CENPM 79019 RNAseq 0.5292 0.0035
SRP159526 CENPM 79019 RNAseq 1.2331 0.0000
SRP193095 CENPM 79019 RNAseq 0.5235 0.0000
SRP219564 CENPM 79019 RNAseq 1.4352 0.0255
TCGA CENPM 79019 RNAseq 1.2900 0.0000

Upregulated datasets: 10; Downregulated datasets: 0.  

 

Survival by CENPM expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CENPM:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CENPM 79019 6 5 19
GSE20123 CENPM 79019 6 4 20
GSE43470 CENPM 79019 5 6 32
GSE46452 CENPM 79019 31 2 26
GSE47630 CENPM 79019 9 4 27
GSE54993 CENPM 79019 3 6 61
GSE54994 CENPM 79019 11 8 34
GSE60625 CENPM 79019 5 0 6
GSE74703 CENPM 79019 5 4 27
GSE74704 CENPM 79019 3 2 15
TCGA CENPM 79019 27 14 55

Total number of gains: 111; Total number of losses: 55; Total Number of normals: 322.  

 

Somatic mutations of CENPM:

 

Generating mutation plots.

 

Highly correlated genes for CENPM:

 

Showing top 20/1920 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CENPMCDC450.82701412012
CENPMGINS20.80605512012
CENPMCCNB20.8020412012
CENPMMCM20.79758612012
CENPMNCAPH0.795024909
CENPMUBE2C0.79472713013
CENPMSPAG50.79309313012
CENPMGINS10.79154112012
CENPMMYBL20.78667612012
CENPMTOP2A0.78395413013
CENPMUBE2T0.782622909
CENPMBIRC50.78162413012
CENPMTRIP130.78130912012
CENPMKNSTRN0.777971707
CENPMMCM50.77652312010
CENPMBLM0.77628613013
CENPMCDCA30.77576813012
CENPMNUSAP10.7750913012
CENPMDTL0.77377813013
CENPMCENPF0.77107313013

For details and further investigation, click here